Search Results - "Engelke, Michael"

SH2 domain-containing inositol 5-phosphatases support the survival of Burkitt lymphoma cells by promoting energy metabolism by Mayr, Florian, Kruse, Vanessa, Fuhrmann, Dominik C, Wolf, Sebastian, Löber, Jens, Alsouri, Saed, Paglilla, Nadia, Lee, Kwang, Chapuy, Björn, Brüne, Bernhard, Zenz, Thorsten, Häupl, Björn, Oellerich, Thomas, Engelke, Michael

“…Burkitt lymphoma cells (BL) exploit antigen-independent tonic signals transduced by the B-cell antigen receptor (BCR) for their survival, but the molecular…”
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Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness by Wong, Leo E., Bhatt, Arshiya, Erdmann, Philipp S., Hou, Zhen, Maier, Joachim, Pirkuliyeva, Sona, Engelke, Michael, Becker, Stefan, Plitzko, Jürgen, Wienands, Jürgen, Griesinger, Christian

“…Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and the proper engagement of its intracellular signal…”
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Characterization of testicular macrophage subpopulations in mice by Gayer, Fabian A., Reichardt, Sybille D., Bohnenberger, Hanibal, Engelke, Michael, Reichardt, Holger M.

“…•MHC class II and CD206 discriminate two distinct testicular macrophage subtypes.•Scavenger receptor expression is largely confined to interstitial testicular…”
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The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain by Schneppenheim, Janna, Dressel, Ralf, Hüttl, Susann, Lüllmann-Rauch, Renate, Engelke, Michael, Dittmann, Kai, Wienands, Jürgen, Eskelinen, Eeva-Liisa, Hermans-Borgmeyer, Irm, Fluhrer, Regina, Saftig, Paul, Schröder, Bernd

“…Regulated intramembrane proteolysis is a central cellular process involved in signal transduction and membrane protein turnover. The presenilin homologue…”
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Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells by Castello, Angelo, Gaya, Mauro, Tucholski, Johannes, Oellerich, Thomas, Lu, Kun-Hui, Tafuri, Anna, Pawson, Tony, Wienands, Jürgen, Engelke, Michael, Batista, Facundo D

“…The adaptor Nck is known for linking TCR signaling to cytoskeleton regulation. Batista and colleagues show that in B cells, Nck recruits the adaptor BCAP to…”
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B Cell Receptor-Mediated Antigen Gathering Requires Ubiquitin Ligase Cbl and Adaptors Grb2 and Dok-3 to Recruit Dynein to the Signaling Microcluster by Schnyder, Tim, Castello, Angelo, Feest, Christoph, Harwood, Naomi E., Oellerich, Thomas, Urlaub, Henning, Engelke, Michael, Wienands, Jürgen, Bruckbauer, Andreas, Batista, Facundo D.

“…The B cell receptor (BCR) mediates B cell antigen gathering and acquisition for presentation to T cells. Although the amount of antigen presentation to T cells…”
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The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation by Isernhagen, Antje, Malzahn, Dörthe, Viktorova, Elena, Elsner, Leslie, Monecke, Sebastian, von Bonin, Frederike, Kilisch, Markus, Wermuth, Janne Marieke, Walther, Neele, Balavarca, Yesilda, Stahl‐Hennig, Christiane, Engelke, Michael, Walter, Lutz, Bickeböller, Heike, Kube, Dieter, Wulf, Gerald, Dressel, Ralf

“…The MHC class I chain‐related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK)‐cell receptor NKG2D. A single nucleotide…”
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DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk by Justa-Schuch, Daniela, Silva-Garcia, Maria, Pilla, Esther, Engelke, Michael, Kilisch, Markus, Lenz, Christof, Möller, Ulrike, Nakamura, Fumihiko, Urlaub, Henning, Geiss-Friedlander, Ruth

“…The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in second position. Although linked to several pathways…”
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The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 by Oellerich, Thomas, Bremes, Vanessa, Neumann, Konstantin, Bohnenberger, Hanibal, Dittmann, Kai, Hsiao, He-Hsuan, Engelke, Michael, Schnyder, Tim, Batista, Facundo D, Urlaub, Henning, Wienands, Jürgen

“…Spleen tyrosine kinase Syk and its substrate SLP65 (also called BLNK) are proximal signal transducer elements of the B‐cell antigen receptor (BCR). Yet, our…”
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Ca²⁺ signaling in antigen receptor-activated B lymphocytes by Engelke, Michael, Engels, Niklas, Dittmann, Kai, Stork, Björn, Wienands, Jürgen

“…B cells respond to antigen stimulation with mobilization of the Ca²⁺ second messenger in two phases operated by two distinct sets of effector proteins. First,…”
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Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells by Engelke, Michael, Pirkuliyeva, Sona, Kühn, Julius, Wong, Leo, Boyken, Janina, Herrmann, Nadine, Becker, Stefan, Griesinger, Christian, Wienands, Jürgen

“…The traditional view of how intracellular effector proteins are recruited to the B cell antigen receptor (BCR) complex at the plasma membrane is based on the…”
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Spatiotemporal resolution of Ca2+ signaling events by real time imaging of single B cells by Junek, Stephan, Engelke, Michael, Schild, Detlev, Wienands, Jürgen

“…► A multi-parameter approach to visualize intracellular signaling events in the live B cell. ► The subcellular translocation of signaling proteins precedes…”
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Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells by Stork, Björn, Neumann, Konstantin, Goldbeck, Ingo, Alers, Sebastian, Kähne, Thilo, Naumann, Michael, Engelke, Michael, Wienands, Jürgen

“…Spatial and temporal modulation of intracellular Ca2+ fluxes controls the cellular response of B lymphocytes to antigen stimulation. Herein, we identify the…”
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β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis by Oellerich, Thomas, Oellerich, Mark F., Engelke, Michael, Münch, Silvia, Mohr, Sebastian, Nimz, Marika, Hsiao, He-Hsuan, Corso, Jasmin, Zhang, Jing, Bohnenberger, Hanibal, Berg, Tobias, Rieger, Michael A., Wienands, Jürgen, Bug, Gesine, Brandts, Christian, Urlaub, Henning, Serve, Hubert

“…Spleen tyrosine kinase (Syk) induces cell survival and proliferation in a high proportion of acute myeloid leukemia (AML) blasts, but the underlying molecular…”
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Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas by Schrader, Alexandra, Meyer, Katharina, von Bonin, Frederike, Vockerodt, Martina, Walther, Neele, Hand, Elisabeth, Ulrich, Antje, Matulewicz, Kamila, Lenze, Dido, Hummel, Michael, Kieser, Arnd, Engelke, Michael, Trümper, Lorenz, Kube, Dieter

“…Aggressive Non-Hodgkin lymphomas (NHL) are a group of lymphomas derived from germinal centre B cells which display a heterogeneous pattern of oncogenic pathway…”
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Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation by Sieme, Daniel, Engelke, Michael, Rezaei-Ghaleh, Nasrollah, Becker, Stefan, Wienands, Jürgen, Griesinger, Christian

“…Signal transduction by the ligated B cell antigen receptor (BCR) depends on the preorganization of its intracellular components, such as the effector proteins…”
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Actinin‐4 controls survival signaling in B cells by limiting the lateral mobility of B‐cell antigen receptors by Alsouri, Saed, Ambrose, Ashley, Mougios, Nikolaos, Paglilla, Nadia, Mayr, Florian, Choi, Kate, Loeber, Jens, Chapuy, Björn, Haeupl, Björn, Opazo, Felipe, Oellerich, Thomas, Gold, Michael, Engelke, Michael

“…The structure and dynamics of F‐actin networks in the cortical area of B cells control the signal efficiency of B‐cell antigen receptors (BCRs). Although…”
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Highly selective organ distribution and cellular uptake of inorganic-organic hybrid nanoparticles customized for the targeted delivery of glucocorticoids by Kaiser, Tina K., Khorenko, Mikhail, Moussavi, Amir, Engelke, Michael, Boretius, Susann, Feldmann, Claus, Reichardt, Holger M.

“…We previously reported that inorganic-organic hybrid nanoparticles (IOH-NPs) containing the synthetic glucocorticoid (GC) betamethasone show efficient…”
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Ca(2+) signaling in antigen receptor-activated B lymphocytes by Engelke, Michael, Engels, Niklas, Dittmann, Kai, Stork, Björn, Wienands, Jürgen

“…B cells respond to antigen stimulation with mobilization of the Ca(2+) second messenger in two phases operated by two distinct sets of effector proteins…”
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Elucidation of tonic and activated B-cell receptor signaling in Burkitt’s lymphoma provides insights into regulation of cell survival by Corso, Jasmin, Pan, Kuan-Ting, Walter, Roland, Doebele, Carmen, Mohr, Sebastian, Bohnenberger, Hanibal, Ströbel, Philipp, Lenz, Christof, Slabicki, Mikolaj, Hüllein, Jennifer, Comoglio, Federico, Rieger, Michael A., Zenz, Thorsten, Wienands, Jürgen, Engelke, Michael, Serve, Hubert, Urlaub, Henning, Oellerich, Thomas

“…Burkitt’s lymphoma (BL) is a highly proliferative B-cell neoplasm and is treated with intensive chemotherapy that, because of its toxicity, is often not…”
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