Search Results - "Engebraten, Olav"

Breast cancer quantitative proteome and proteogenomic landscape by Johansson, Henrik J., Socciarelli, Fabio, Vacanti, Nathaniel M., Haugen, Mads H., Zhu, Yafeng, Siavelis, Ioannis, Fernandez-Woodbridge, Alejandro, Aure, Miriam R., Sennblad, Bengt, Vesterlund, Mattias, Branca, Rui M., Orre, Lukas M., Huss, Mikael, Fredlund, Erik, Beraki, Elsa, Garred, Øystein, Boekel, Jorrit, Sauer, Torill, Zhao, Wei, Nord, Silje, Höglander, Elen K., Jans, Daniel C., Brismar, Hjalmar, Haukaas, Tonje H., Bathen, Tone F., Schlichting, Ellen, Naume, Bjørn, Luders, Torben, Borgen, Elin, Kristensen, Vessela N., Russnes, Hege G., Lingjærde, Ole Christian, Mills, Gordon B., Sahlberg, Kristine K., Børresen-Dale, Anne-Lise, Lehtiö, Janne

“…In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased…”
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Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation by Erdélyi, Katalin, Ditrói, Tamás, Johansson, Henrik J., Czikora, Ágnes, Balog, Noémi, Silwal-Pandit, Laxmi, Ida, Tomoaki, Olasz, Judit, Hajdú, Dorottya, Mátrai, Zoltán, Csuka, Orsolya, Uchida, Koji, Tóvári, József, Engebraten, Olav, Akaike, Takaaki, Dale, Anne-Lise Børresen, Kásler, Miklós, Lehtiö, Janne, Nagy, Péter

“…Basal-like breast cancer (BLBC) is the most aggressive subtype of breast tumors with poor prognosis and limited molecular-targeted therapy options. We show…”
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The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers by Knutsen, Erik, Lellahi, Seyed Mohammad, Aure, Miriam Ragle, Nord, Silje, Fismen, Silje, Larsen, Kenneth Bowitz, Gabriel, Marta Tellez, Hedberg, Annica, Bjørklund, Sunniva Stordal, Bofin, Anna Mary, Mælandsmo, Gunhild Mari, Sørlie, Therese, Mortensen, Elin Synnøve, Perander, Maria

“…The long non-coding RNA NEAT1 locus is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2 , of which the latter is essential for the assembly of…”
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DNA copy number motifs are strong and independent predictors of survival in breast cancer by Pladsen, Arne V., Nilsen, Gro, Rueda, Oscar M., Aure, Miriam R., Borgan, Ørnulf, Liestøl, Knut, Vitelli, Valeria, Frigessi, Arnoldo, Langerød, Anita, Mathelier, Anthony, Engebråten, Olav, Kristensen, Vessela, Wedge, David C., Van Loo, Peter, Caldas, Carlos, Børresen-Dale, Anne-Lise, Russnes, Hege G., Lingjærde, Ole Christian

“…Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal…”
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An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment by Tekpli, Xavier, Lien, Tonje, Røssevold, Andreas Hagen, Nebdal, Daniel, Borgen, Elin, Ohnstad, Hege Oma, Kyte, Jon Amund, Vallon-Christersson, Johan, Fongaard, Marie, Due, Eldri Undlien, Svartdal, Lisa Gregusson, Sveli, My Anh Tu, Garred, Øystein, Frigessi, Arnoldo, Sahlberg, Kristine Kleivi, Sørlie, Therese, Russnes, Hege G., Naume, Bjørn, Kristensen, Vessela N.

“…How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we…”
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5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (review) by Friesen, Scott A, Hjortland, Geir Olav, Madsen, Steen J, Hirschberg, Henry, Engebraten, Olav, Nesland, Jahn M, Peng, Qian

“…With current treatment methods the prognosis for patients with aggressive brain tumors is dismal. Treatment failure is usually due to local recurrence of…”
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Breast cancer patient-derived explant cultures recapitulate in vivo drug responses by Pettersen, Solveig, Øy, Geir Frode, Egeland, Eivind Valen, Juell, Siri, Engebråten, Olav, Mælandsmo, Gunhild Mari, Prasmickaite, Lina

“…Assessment of drug sensitivity in tumor tissue may significantly contribute to functional diagnostics to guide personalized treatment of cancer. Tumor…”
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Basal‐like breast cancer engages tumor‐supportive macrophages via secreted factors induced by extracellular S100A4 by Prasmickaite, Lina, Tenstad, Ellen M., Pettersen, Solveig, Jabeen, Shakila, Egeland, Eivind V., Nord, Silje, Pandya, Abhilash, Haugen, Mads H., Kristensen, Vessela N., Børresen‐Dale, Anne‐Lise, Engebråten, Olav, Mælandsmo, Gunhild M.

“…The tumor microenvironment (TME) may influence both cancer progression and therapeutic response. In breast cancer, particularly in the aggressive…”
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PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles by Engesaeter, Birgit Ø, Bonsted, Anette, Berg, Kristian, Høgset, Anders, Engebråten, Olav, Fodstad, Øystein, Curiel, David T, Maelandsmo, Gunhild M

“…The development of methods for efficient and specific delivery of therapeutic genes into target tissues is an important issue for further development of in…”
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Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer by Lesurf, Robert, Aure, Miriam Ragle, Mørk, Hanne Håberg, Vitelli, Valeria, Sauer, Torill, Geisler, Jürgen, Hofvind, Solveig, Borgen, Elin, Børresen-Dale, Anne-Lise, Engebråten, Olav, Fodstad, Øystein, Garred, Øystein, Geitvik, Gry Aarum, Kåresen, Rolf, Naume, Bjørn, Mælandsmo, Gunhild Mari, Russnes, Hege G., Schlichting, Ellen, Sørlie, Therese, Lingjærde, Ole Christian, Kristensen, Vessela, Sahlberg, Kristine Kleivi, Skjerven, Helle Kristine, Fritzman, Britt, Lundgren, Steinar, Børresen-Dale, Anne-Lise, Kristensen, Vessela, Wärnberg, Fredrik, Hallett, Michael, Sørlie, Therese

“…Breast cancer consists of at least five main molecular “intrinsic” subtypes that are reflected in both pre-invasive and invasive disease. Although previous…”
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pH-Responsive Nano Carriers for Doxorubicin Delivery by Bagherifam, Shahla, Skjeldal, Frode Miltzow, Griffiths, Gareth, Mælandsmo, Gunhild M., Engebråten, Olav, Nyström, Bo, Hasirci, Vasif, Hasirci, Nesrin

“…Purpose The aim of this study was to design stimuli-responsive nanocarriers for anti-cancer drug delivery. For this purpose, doxorubicin (DOX)-loaded,…”
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Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer by Moestue, Siver A, Dam, Cornelia G, Gorad, Saurabh S, Kristian, Alexandr, Bofin, Anna, Mælandsmo, Gunhild M, Engebråten, Olav, Gribbestad, Ingrid S, Bjørkøy, Geir

“…The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in cancer cells through numerous mutations and epigenetic changes. The recent…”
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MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients by Mo, Torgeir, Brandal, Siri Helene Bertelsen, Geier, Oliver Marcel, Engebråten, Olav, Nilsen, Line Brennhaug, Kristensen, Vessela N, Hole, Knut Håkon, Hompland, Tord, Fleischer, Thomas, Seierstad, Therese

“…Anti-VEGF (vascular endothelial growth factor) treatment improves response rates, but not progression-free or overall survival in advanced breast cancer. It…”
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Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model by Kim, Eugene, Tunset, Hanna Maja, Cebulla, Jana, Vettukattil, Riyas, Helgesen, Heidi, Feuerherm, Astrid Jullumstrø, Engebråten, Olav, Mælandsmo, Gunhild Mari, Johansen, Berit, Moestue, Siver Andreas

“…Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer…”
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Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft by Pandya, Abhilash D, Iversen, Tore-Geir, Moestue, Siver, Grinde, Maria T, Mørch, Ýrr, Snipstad, Sofie, Åslund, Andreas K O, Øy, Geir F, Kildal, Wanja, Engebråten, Olav, Sandvig, Kirsten, Skotland, Tore, Mælandsmo, Gunhild M

“…We have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs):…”
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Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions by Bergholtz, Helga, Lien, Tonje G., Swanson, David M., Frigessi, Arnoldo, Daidone, Maria Grazia, Tost, Jörg, Wärnberg, Fredrik, Sørlie, Therese

“…Ductal carcinoma in situ (DCIS) is a non-invasive type of breast cancer with highly variable potential of becoming invasive and affecting mortality. Currently,…”
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Targeting inhibitor of apoptosis proteins in combination with dacarbazine or TRAIL in melanoma cells by Engesæter, Birgit Ø., Sathermugathevan, Menaka, Hellenes, Tina, Engebråten, Olav, Holm, Ruth, Flørenes, Vivi Ann, Mælandsmo, Gunhild M.

“…Melanoma is a highly aggressive malignant tumor with an exceptional ability to develop resistance and no curative therapy is available for patients with…”
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Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts by Esmaeili, Morteza, Bathen, Tone F., Engebråten, Olav, Mælandsmo, Gunhild M., Gribbestad, Ingrid S., Moestue, Siver A.

“…Purpose Phospholipid metabolites are of importance in cancer studies, and have been suggested as candidate metabolic biomarkers for response to targeted…”
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In Vivo 31P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts by Esmaeili, Morteza, Moestue, Siver A., Hamans, Bob C., Veltien, Andor, Kristian, Alexandr, Engebråten, Olav, Mælandsmo, Gunhild M., Gribbestad, Ingrid S., Bathen, Tone F., Heerschap, Arend

“…Purpose To study cancer associated with abnormal metabolism of phospholipids, of which several have been proposed as biomarkers for malignancy or to monitor…”
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Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells by Prasmickaite, Lina, Skrbo, Nirma, Høifødt, Hanne K., Suo, Zhenhe, Engebråten, Olav, Gullestad, Hans P., Aamdal, Steinar, Fodstad, Øystein, Mælandsmo, Gunhild M.

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