Search Results - "Engberg, Susanna"

Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing by Wimberger, Sandra, Akrap, Nina, Firth, Mike, Brengdahl, Johan, Engberg, Susanna, Schwinn, Marie K., Slater, Michael R., Lundin, Anders, Hsieh, Pei-Pei, Li, Songyuan, Cerboni, Silvia, Sumner, Jonathan, Bestas, Burcu, Schiffthaler, Bastian, Magnusson, Björn, Di Castro, Silvio, Iyer, Preeti, Bohlooly-Y, Mohammad, Machleidt, Thomas, Rees, Steve, Engkvist, Ola, Norris, Tyrell, Cadogan, Elaine B., Forment, Josep V., Šviković, Saša, Akcakaya, Pinar, Taheri-Ghahfarokhi, Amir, Maresca, Marcello

“…Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid…”
Get full text

Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes by Zabulica, Mihaela, Srinivasan, Raghuraman C., Akcakaya, Pinar, Allegri, Gabriella, Bestas, Burcu, Firth, Mike, Hammarstedt, Christina, Jakobsson, Tomas, Jakobsson, Towe, Ellis, Ewa, Jorns, Carl, Makris, Georgios, Scherer, Tanja, Rimann, Nicole, van Zuydam, Natalie R., Gramignoli, Roberto, Forslöw, Anna, Engberg, Susanna, Maresca, Marcello, Rooyackers, Olav, Thöny, Beat, Häberle, Johannes, Rosen, Barry, Strom, Stephen C.

“…Ornithine transcarbamylase deficiency (OTCD) is a monogenic disease of ammonia metabolism in hepatocytes. Severe disease is frequently treated by orthotopic…”
Get full text

Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3 by Leffler, Agnes, Ahlstedt, Ingela, Engberg, Susanna, Svensson, Arne, Billger, Martin, Öberg, Lisa, Bjursell, Magnus K., Lindström, Erik, von Mentzer, Bengt

“…Experiments with neurokinin receptors (NKRs) demonstrate that not only human, but also dog and gerbil NKR displays similar antagonist pharmacology while rat…”
Get full text

Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors by Engberg, Susanna, Ahlstedt, Ingela, Leffler, Agnes, Lindström, Erik, Kristensson, Elin, Svensson, Arne, Påhlman, Ingrid, Johansson, Anders, Drmota, Tomas, von Mentzer, Bengt

“…The present study investigates the pharmacology of the cloned neurokinin 1 receptor from the gerbil (gNK1R), a species claimed to have human-like NK1R (hNK1R)…”
Get full text

Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver by Svensson, L T, Engberg, S T, Aoyama, T, Usuda, N, Alexson, S E, Hashimoto, T

“…We have previously reported the purification and characterization of the peroxisome proliferator-induced very-long-chain acyl-CoA thioesterase (MTE-I) from rat…”
Get full text

Succinate receptor GPR91, a Gα(i) coupled receptor that increases intracellular calcium concentrations through PLCβ by Sundström, Linda, Greasley, Peter J, Engberg, Susanna, Wallander, Malin, Ryberg, Erik

“…Succinate has been reported as the endogenous ligand for GPR91. In this study, succinate was confirmed to activate GPR91 resulting in both 3'-5'-cyclic…”
Get full text

Succinate receptor GPR91, a Gαi coupled receptor that increases intracellular calcium concentrations through PLCβ by Sundström, Linda, Greasley, Peter J., Engberg, Susanna, Wallander, Malin, Ryberg, Erik

“…•Succinate activates GPR91 mediated calcium release in a PTX-sensitive manner.•Activation of GPR91 in HEK293 cells is solely dependent on Gαi.•GPR91 signalling…”
Get full text

A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes by Loregger, Anke, Cook, Emma Claire Laura, Nelson, Jessica Kristin, Moeton, Martina, Sharpe, Laura Jane, Engberg, Susanna, Karimova, Madina, Lambert, Gilles, Brown, Andrew John, Zelcer, Noam

“…Cholesterol synthesis and lipoprotein uptake are tightly coordinated to ensure that the cellular level of cholesterol is adequately maintained. Hepatic…”
Get full text

G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes by Lin, Li-Chiung, Quon, Tezz, Engberg, Susanna, Mackenzie, Amanda E, Tobin, Andrew B, Milligan, Graeme

“…Although prevalent, nonalcoholic fatty liver disease is not currently treated effectively with medicines. Initially, using wild-type and genome-edited clones…”
Get full text

Enabling 1536-Well High-Throughput Cell-Based Screening through the Application of Novel Centrifugal Plate Washing by Knight, Sinead, Plant, Helen, McWilliams, Lisa, Murray, David, Dixon-Steele, Rebecca, Varghese, Anet, Harper, Paul, Ramne, Anna, McArdle, Paula, Engberg, Susanna, Bennett, Neil, Blackett, Carolyn, Wigglesworth, Mark

“…Cell-based assays have long been important within hit discovery paradigms; however, improving the disease relevance of the assay system can positively affect…”
Get more information

Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists by Sundqvist, Monika, Kristensson, Elin, Adolfsson, Rebecka, Leffler, Agnes, Ahlstedt, Ingela, Engberg, Susanna, Drmota, Tomas, Sigfridsson, Kalle, Jussila, Rainer, de Verdier, Jennie, Novén, Anna, Johansson, Anders, Påhlman, Ingrid, von Mentzer, Bengt, Lindström, Erik

“…Intracerebroventricular (i.c.v.) administration of tachykinin NK(1) receptor agonists induces tapping of the hind legs in gerbils, so-called gerbil foot…”
Get full text

Occurrence and pharmacological characterization of four human tachykinin NK sub(2) receptor variants by Ahlstedt, Ingela, Engberg, Susanna, Smith, John, Perrey, Chris, Moody, Adrian, Morten, John, Lagerstroem-Fermer, Maria, Drmota, Tomas, Von Mentzer, Bengt, Paahlman, Ingrid, Lindstroem, Erik

“…Tachykinin NK sub(2) receptor antagonists are potentially beneficial in treating various disorders including irritable bowel syndrome, urinary incontinence,…”
Get full text

Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants by AHLSTEDT, Ingela, ENGBERG, Susanna, LINDSTRÖM, Erik, SMITH, John, PERREY, Chris, MOODY, Adrian, MORTEN, John, LAGERSTRÖM-FERMER, Maria, DRMOTA, Tomas, VON MENTZER, Bengt, PAHLMAN, Ingrid

“…Tachykinin NK(2) receptor antagonists are potentially beneficial in treating various disorders including irritable bowel syndrome, urinary incontinence,…”
Get full text

Occurrence and pharmacological characterization of four human tachykinin NK 2 receptor variants by Ahlstedt, Ingela, Engberg, Susanna, Smith, John, Perrey, Chris, Moody, Adrian, Morten, John, Lagerström-Fermér, Maria, Drmota, Tomas, von Mentzer, Bengt, Påhlman, Ingrid, Lindström, Erik

“…Tachykinin NK 2 receptor antagonists are potentially beneficial in treating various disorders including irritable bowel syndrome, urinary incontinence,…”
Get full text

Molecular cloning, mutations and effects of NK sub(1) receptor antagonists reveal the human-like pharmacology of gerbil NK sub(1) receptors by Engberg, Susanna, Ahlstedt, Ingela, Leffler, Agnes, Lindstroem, Erik, Kristensson, Elin, Svensson, Arne, Paahlman, Ingrid, Johansson, Anders, Drmota, Tomas, Von Mentzer, Bengt

“…The present study investigates the pharmacology of the cloned neurokinin 1 receptor from the gerbil (gNK sub(1)R), a species claimed to have human-like NK…”
Get full text

Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 aand NK3 receptor antagonists by SUNDQVIST, Monika, KRISTENSSON, Elin, NOVEN, Anna, JOHANSSON, Anders, PAHLMAN, Ingrid, VON MENTZER, Bengt, LINDSTRÖM, Erik, ADOLFSSON, Rebecka, LEFFLER, Agnes, AHLSTEDT, Ingela, ENGBERG, Susanna, DRMOTA, Tomas, SIGFRIDSSON, Kalle, JUSSILA, Rainer, DE VERDIER, Jennie

Get full text

Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK 1 and NK 3 receptor antagonists by Sundqvist, Monika, Kristensson, Elin, Adolfsson, Rebecka, Leffler, Agnes, Ahlstedt, Ingela, Engberg, Susanna, Drmota, Tomas, Sigfridsson, Kalle, Jussila, Rainer, de Verdier, Jennie, Novén, Anna, Johansson, Anders, Påhlman, Ingrid, von Mentzer, Bengt, Lindström, Erik

“…Intracerebroventricular (i.c.v.) administration of tachykinin NK 1 receptor agonists induces tapping of the hind legs in gerbils, so-called gerbil foot…”
Get full text

Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells by Engberg, S T, Aoyama, T, Alexson, S E, Hashimoto, T, Svensson, L T

“…We have isolated and cloned a cDNA that codes for one of the peroxisome proliferator-induced acyl-CoA thioesterases of rat liver. The deduced amino acid…”
Get full text