Search Results - "Eng, Jason W."

β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8 + T Cells and Undermines Checkpoint Inhibitor Therapy by Bucsek, Mark J, Qiao, Guanxi, MacDonald, Cameron R, Giridharan, Thejaswini, Evans, Lauren, Niedzwecki, Brian, Liu, Haichao, Kokolus, Kathleen M, Eng, Jason W-L, Messmer, Michelle N, Attwood, Kristopher, Abrams, Scott I, Hylander, Bonnie L, Repasky, Elizabeth A

“…The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We…”
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Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature by Kokolus, Kathleen M., Capitano, Maegan L., Lee, Chen-Ting, Eng, Jason W.-L., Waight, Jeremy D., Hylander, Bonnie L., Sexton, Sandra, Hong, Chi-Chen, Gordon, Christopher J., Abrams, Scott I., Repasky, Elizabeth A.

“…We show here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature. Standard housing temperature…”
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Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice by Messmer, Michelle N., Kokolus, Kathleen M., Eng, Jason W.-L., Abrams, Scott I., Repasky, Elizabeth A.

“…Physiologically accurate mouse models of cancer are critical in the pre‐clinical development of novel cancer therapies. However, current standardized…”
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A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response by Eng, Jason W.-L., Kokolus, Kathleen M., Reed, Chelsey B., Hylander, Bonnie L., Ma, Wen W., Repasky, Elizabeth A.

“…Long conserved mechanisms maintain homeostasis in living creatures in response to a variety of stresses. However, continuous exposure to stress can result in…”
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Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells by Povinelli, Benjamin J, Kokolus, Kathleen M, Eng, Jason W-L, Dougher, Christopher W, Curtin, Leslie, Capitano, Maegan L, Sailsbury-Ruf, Christi T, Repasky, Elizabeth A, Nemeth, Michael J

“…The production of new blood cells relies on a hierarchical network of hematopoietic stem and progenitor cells (HSPCs). To maintain lifelong hematopoiesis,…”
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Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium by Eng, Jason W-L, Kato, Yu, Adachi, Yusuke, Swaminathan, Bhairavi, Naiche, L A, Vadakath, Rahul, Sakamoto, Yoshimasa, Nakazawa, Youya, Tachino, Sho, Ito, Ken, Abe, Takanori, Minoshima, Yukinori, Hoshino-Negishi, Kana, Ogasawara, Hideaki, Kawakatsu, Tomomi, Nishimura, Miyuki, Katayama, Masahiko, Shimizu, Masashi, Tahara, Kazuhiro, Sato, Toshitaka, Suzuki, Katsuhisa, Agarwala, Kishan, Iwata, Masao, Nomoto, Kenichi, Ozawa, Yoichi, Imai, Toshio, Funahashi, Yasuhiro, Matsui, Junji, Kitajewski, Jan

“…Endothelial Notch signaling is critical for tumor angiogenesis. Notch1 blockade can interfere with tumor vessel function but causes tissue hypoxia and…”
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The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System by Hylander, Bonnie L, Eng, Jason W-L, Repasky, Elizabeth A

“…In the last 10-15 years, there has been a recognition that the catecholamines (norepinephrine, NE, and epinephrine, Epi) released by the sympathetic nervous…”
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Housing Temperature-Induced Stress Is Suppressing Murine Graft-versus-Host Disease through β2-Adrenergic Receptor Signaling by Leigh, Nicholas D, Kokolus, Kathleen M, O'Neill, Rachel E, Du, Wei, Eng, Jason W-L, Qiu, Jingxin, Chen, George L, McCarthy, Philip L, Farrar, J David, Cao, Xuefang, Repasky, Elizabeth A

“…Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic…”
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Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia by Eng, Jason W-L, Reed, Chelsey B, Kokolus, Kathleen M, Repasky, Elizabeth A

“…Researchers studying the murine response to stress generally use mice housed under standard, nationally mandated conditions as controls. Few investigators are…”
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Nitric oxide and nanotechnology: A novel approach to inhibit neointimal hyperplasia by Kapadia, Muneera R., MD, Chow, Lesley W., BS, Tsihlis, Nick D., PhD, Ahanchi, Sadaf S., MD, Eng, Jason W, Murar, Jozef, BA, Martinez, Janet, AAS, Popowich, Daniel A., MD, Jiang, Qun, MD, Hrabie, Joseph A., PhD, Saavedra, Joseph E., PhD, Keefer, Larry K., PhD, Hulvat, James F., PhD, Stupp, Samuel I., PhD, Kibbe, Melina R., MD

“…Objective Nitric oxide (NO) has been shown to inhibit neointimal hyperplasia after arterial interventions in several animal models. To date, however, NO-based…”
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Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5 by Eng, Jason W.-L., Mace, Thomas A., Sharma, Rohit, Twum, Danielle Y. F., Peng, Peng, Gibbs, John F., Pitoniak, Rosemarie, Reed, Chelsey B., Abrams, Scott I., Repasky, Elizabeth A., Hylander, Bonnie L.

“…BackgroundTherapeutic resistance and tumor recurrence are two major hurdles in the treatment of pancreatic ductal adenocarcinoma. Recent findings suggest that…”
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Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation by Eng, Jason W.-L., Reed, Chelsey B., Kokolus, Kathleen M., Pitoniak, Rosemarie, Utley, Adam, Bucsek, Mark J., Ma, Wen Wee, Repasky, Elizabeth A., Hylander, Bonnie L.

“…Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic…”
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Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell by Bausero, Maria A, Bharti, Ajit, Page, Diana T, Perez, Kristen D, Eng, Jason W-L, Ordonez, Susana L, Asea, Edwina E, Jantschitsch, Christian, Kindas-Muegge, Ingela, Ciocca, Daniel, Asea, Alexzander

“…The 25-kDa heat shock protein (Hsp25) is associated with various malignancies and is expressed at high levels in biopsies as well as circulating in the serum…”
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Nitric oxide regulates the 26S proteasome in vascular smooth muscle cells by Kapadia, Muneera R., Eng, Jason W., Jiang, Qun, Stoyanovsky, Detcho A., Kibbe, Melina R.

“…It is well established that nitric oxide (NO) inhibits vascular smooth muscle cell (VSMC) proliferation by modulating cell cycle proteins. The 26S proteasome…”
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A Reproducible Porcine ePTFE Arterial Bypass Model for Neointimal Hyperplasia by Kapadia, Muneera R., M.D, Aalami, Oliver O., M.D, Najjar, Samer F., M.D, Jiang, Qun, M.D, Murar, Jozef, B.A, Lyle, Brian, B.A, Eng, Jason W, Kane, Bonnie, B.S, Carroll, Timothy, Ph.D, Cahill, Patricia M., D.V.M, Kibbe, Melina R., M.D

“…Background Late failure of prosthetic vascular bypass grafting using expanded polytetrafluoroethylene (ePTFE) is secondary to the development of neointimal…”
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Abstract 1488: A novel Notch4 neutralizing antibody inhibits angiogenesis and tumor growth via a distinct mechanism from endothelial Notch1 inhibition by Naiche, L. A., Swaminathan, Bhairavi, Kato, Yu, Das, Sarita, Eng, Jason W., Raza, Qanber, Thakkar, Krishna, Herts, James H., Emmadi, Rajyasree, Matsui, Junji, Kitajewski, Jan K.

“…Endothelial Notch signaling is critical for tumor angiogenesis and growth. Inhibitors of Notch1 or its ligand Dll4 cause tumor vessel hypersprouting but…”
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Abstract 4605: Chronic VEGF-C signaling exacerbates the progression of non-alcoholic steatohepatitis and hepatocarcinoma through endothelial VEGFR2 and VEGFR3 by Youn, Seock-Won, Eng, Jason W.-L., Swaminathan, Bhairavi, Teneqexhi, Pamela, Vadakath, Rahul, Kitajewski, Jan K.

“…Obesity, aging, and metabolic diseases contribute to non-alcoholic fatty liver disease (NAFLD) that can progress to non-alcoholic steatohepatitis (NASH) due to…”
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Abstract LB009: Notch4 inhibition by a novel neutralizing antibody reduces tumor progression and increases macrophage recruitment within the tumor microenvironment by Eng, Jason W., Naiche, L.A., Swaminathan, Bhairavi, Kato, Yu, Thakkar, Krishna, Alexander, Katherine Ann, Vadakath, Rahul, Herts, James H., Emmadi, Rajyasree, Matsui, Junji, Kitajewski, Jan K.

“…The Notch signaling pathway, particularly endothelial Notch signaling, plays a key role in tumor formation and angiogenesis. Inhibiting Notch1 or its ligand,…”
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Housing Temperature-Induced Stress Is Suppressing Murine Graft-versus-Host Disease through beta 2-Adrenergic Receptor Signaling by Leigh, Nicholas D, Kokolus, Kathleen M, O'Neill, Rachel E, Du, Wei, Eng, Jason W-L, Qiu, Jingxin, Chen, George L, McCarthy, Philip L, Farrar, JDavid, Cao, Xuefang, Repasky, Elizabeth A

“…Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic…”
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Housing temperature-induced stress is suppressing murine GVHD through β2-adrenergic receptor signaling1 by Leigh, Nicholas D., Kokolus, Kathleen M., O’Neill, Rachel E., Du, Wei, Eng, Jason W.-L., Qiu, Jingxin, Chen, George L., McCarthy, Philip L., Farrar, J. David, Cao, Xuefang, Repasky, Elizabeth A.

“…Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation (alloHCT), a potentially curative therapy for…”
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