Search Results - "Eng, Jason S"

Aortic perivascular adipose-derived interleukin-6 contributes to arterial stiffness in low-density lipoprotein receptor deficient mice by Du, Bing, Ouyang, An, Eng, Jason S, Fleenor, Bradley S

“…We tested the hypothesis that aortic perivascular adipose tissue (PVAT) from young low-density lipoprotein receptor-deficient (LDLr(-/-)) mice promotes aortic…”
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Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway by Shen, Ye, Eng, Jason S, Fajardo, Flordeliza, Liang, Lingming, Li, Cong, Collins, Patrick, Tedesco, Donato, Nolan-Stevaux, Olivier

“…BackgroundBispecific T-cell engager (BiTE) molecules induce redirected lysis of cancer cells by T cells and are an emerging modality for solid tumor…”
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Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice by Gioscia-Ryan, Rachel A, Battson, Micah L, Cuevas, Lauren M, Eng, Jason S, Murphy, Michael P, Seals, Douglas R

“…Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction, and other chronic disorders of aging…”
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Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity by Kim, Jennie C., Liu, Xian, Fitzgerald, Karen, Eng, Jason S., Orf, Jessica, O’Brien, Sarah A., Belmontes, Brian, Casbon, Amy-Jo, Novitskiy, Sergey V., Tarbell, Kristin V., DeVoss, Jason, Egen, Jackson G.

“…Type I interferon-mediated activation of immune cells can facilitate the generation of productive tumor antigen-specific T cell responses in solid tumors. The…”
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Superoxide signaling in perivascular adipose tissue promotes age‐related artery stiffness by Fleenor, Bradley S., Eng, Jason S., Sindler, Amy L., Pham, Bryant T., Kloor, Jackson D., Seals, Douglas R.

“…Summary We tested the hypothesis that superoxide signaling within aortic perivascular adipose tissue (PVAT) contributes to large elastic artery stiffening in…”
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Sodium nitrite de-stiffening of large elastic arteries with aging: Role of normalization of advanced glycation end-products by Fleenor, Bradley S., Sindler, Amy L., Eng, Jason S., Nair, Devatha P., Dodson, R. Blair, Seals, Douglas R.

“…We tested the hypothesis that sodium nitrite treatment reverses large elastic artery stiffening in old mice via reductions in collagen I, increases in elastin…”
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Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening by Gioscia-Ryan, Rachel A., Clayton, Zachary S., Fleenor, Bradley S., Eng, Jason S., Johnson, Lawrence C., Rossman, Matthew J., Zigler, Melanie C., Evans, Trent D., Seals, Douglas R.

“…Aortic stiffening, assessed as pulse-wave velocity (PWV), increases with age and is an important antecedent to, and independent predictor of, cardiovascular…”
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Perivascular adipose tissue contributes to large elastic artery stiffness with aging and is associated with greater superoxide bioavailability by Fleenor, Bradley Stephen, Eng, Jason S, Pham, Bryant T, Kloor, Jackson D, Seals, Douglas R

“…Abstract only We tested the hypothesis that perivascular adipose tissue (PVAT) contributes to age‐related large elastic artery stiffening and is associated…”
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Circulating plasma factors contribute to age‐associated arterial stiffness by Johnson, Lawrence Cody, Eng, Jason S., Fleenor, Bradley S., Seals, Douglas R., Sindler, Amy L.

“…Abstract only Previous findings from our laboratory showed that age‐related increases in large elastic artery stiffness in mice are associated with remodeling…”
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Advanced Glycation End‐Products in Age‐Related Arterial Stiffening: Modulation by Sodium Nitrite by Eng, Jason S, Sindler, Amy L, Seals, Douglas R, Fleenor, Bradley S

“…Abstract only Aging causes large elastic artery stiffening and this is associated with oxidative stress and increased advanced glycation end‐products (AGEs)…”
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