Search Results - "Enfield, Katey S.S."

Human endogenous retrovirus onco-exaptation counters cancer cell senescence through Calbindin by Attig, Jan, Pape, Judith, Doglio, Laura, Kazachenka, Anastasiya, Ottina, Eleonora, Young, George R, Enfield, Katey Ss, Aramburu, Iker Valle, Ng, Kevin W, Faulkner, Nikhil, Bolland, William, Papayannopoulos, Venizelos, Swanton, Charles, Kassiotis, George

“…Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterizes most cancer types, linked with disease outcomes. However, the…”
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Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology by Martinez, Victor D., Vucic, Emily A., Thu, Kelsie L., Hubaux, Roland, Enfield, Katey S.S., Pikor, Larissa A., Becker-Santos, Daiana D., Brown, Carolyn J., Lam, Stephen, Lam, Wan L.

“…Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic…”
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An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence by Martinez, Victor D., Enfield, Katey S. S., Rowbotham, David A., Lam, Wan L.

“…The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the…”
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HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer by Firmino, Natalie, Martinez, Victor D, Rowbotham, David A, Enfield, Katey S.S, Bennewith, Kevin L, Lam, Wan L

“…Highlights • piRNAs are differentially expressed between HNSC and non-malignant tissues. • piRNA expression patterns are specific to the HPV status of the…”
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Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions by Gibb, Ewan A, Enfield, Katey S.S, Stewart, Greg L, Lonergan, Kim M, Chari, Raj, Ng, Raymond T, Zhang, Lewei, MacAulay, Calum E, Rosin, Miriam P, Lam, Wan L

“…Summary Oral epithelial dysplasias are believed to progress through a series of histopathological stages; from mild to severe dysplasia, to carcinoma in situ ,…”
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Aberrant expression of long noncoding RNAs in cervical intraepithelial neoplasia by Gibb, Ewan A, Becker-Santos, Daiana D, Enfield, Katey S S, Guillaud, Martial, Niekerk, Dirk van, Matisic, Jasenka P, Macaulay, Calum E, Lam, Wan L

“…Long noncoding RNAs (lncRNAs) are a unique class of messenger RNA-like transcripts of at least 200 nucleotides in length with no significant protein-coding…”
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Expanding the miRNA Transcriptome of Human Kidney and Renal Cell Carcinoma by Lam, Wan L., Stewart, Greg L., Martinez, Victor D., Marshall, Erin A., Minatel, Brenda C., Sage, Adam P., Enfield, Katey S. S.

“…Despite advancements in therapeutic strategies, diagnostic and prognostic molecular markers of kidney cancer remain scarce, particularly in patients who do not…”
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Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma by Lam, Wan L., Stewart, Greg L., Vucic, Emily A., Thu, Kelsie L., Martinez, Victor D., Enfield, Katey S. S., Rowbotham, David A., Bennewith, Kevin L.

“…Pheochromocytomas (PCC) are rare tumors that arise in chromaffin tissue of the adrenal gland. PCC are frequently inherited through predisposing mutations in…”
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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA by Abbosh, Christopher, Frankell, Alexander M., Harrison, Thomas, Kisistok, Judit, Garnett, Aaron, Johnson, Laura, Veeriah, Selvaraju, Moreau, Mike, Chesh, Adrian, Chaunzwa, Tafadzwa L., Weiss, Jakob, Schroeder, Morgan R., Ward, Sophia, Grigoriadis, Kristiana, Shahpurwalla, Aamir, Litchfield, Kevin, Puttick, Clare, Biswas, Dhruva, Karasaki, Takahiro, Black, James R. M., Martínez-Ruiz, Carlos, Bakir, Maise Al, Pich, Oriol, Watkins, Thomas B. K., Lim, Emilia L., Huebner, Ariana, Moore, David A., Godin-Heymann, Nadia, L’Hernault, Anne, Bye, Hannah, Odell, Aaron, Roberts, Paula, Gomes, Fabio, Patel, Akshay J., Manzano, Elizabeth, Hiley, Crispin T., Carey, Nicolas, Riley, Joan, Cook, Daniel E., Hodgson, Darren, Stetson, Daniel, Barrett, J. Carl, Kortlever, Roderik M., Evan, Gerard I., Hackshaw, Allan, Daber, Robert D., Shaw, Jacqui A., Aerts, Hugo J. W. L., Licon, Abel, Stahl, Josh, Jamal-Hanjani, Mariam, Birkbak, Nicolai J., McGranahan, Nicholas, Swanton, Charles

“…Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy 1 . The study of large patient…”
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Piwi-interacting RNAs in cancer: emerging functions and clinical utility by Ng, Kevin W, Anderson, Christine, Marshall, Erin A, Minatel, Brenda C, Enfield, Katey S S, Saprunoff, Heather L, Lam, Wan L, Martinez, Victor D

“…PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human…”
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Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma by Zhang, Hanyun, AbdulJabbar, Khalid, Moore, David A, Akarca, Ayse, Enfield, Katey S S, Jamal-Hanjani, Mariam, Raza, Shan E Ahmed, Veeriah, Selvaraju, Salgado, Roberto, McGranahan, Nicholas, Le Quesne, John, Swanton, Charles, Marafioti, Teresa, Yuan, Yinyin

“…Beyond tertiary lymphoid structures, a significant number of immune-rich areas without germinal center-like structures are observed in non-small cell lung…”
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Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis by Marshall, Erin A, Ng, Kevin W, Kung, Sonia H Y, Conway, Emma M, Martinez, Victor D, Halvorsen, Elizabeth C, Rowbotham, David A, Vucic, Emily A, Plumb, Adam W, Becker-Santos, Daiana D, Enfield, Katey S S, Kennett, Jennifer Y, Bennewith, Kevin L, Lockwood, William W, Lam, Stephen, English, John C, Abraham, Ninan, Lam, Wan L

“…Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have…”
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Human cancer long non-coding RNA transcriptomes by Gibb, Ewan A, Vucic, Emily A, Enfield, Katey S S, Stewart, Greg L, Lonergan, Kim M, Kennett, Jennifer Y, Becker-Santos, Daiana D, MacAulay, Calum E, Lam, Stephen, Brown, Carolyn J, Lam, Wan L

“…Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian…”
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Abstract B15: Increased presence of T follicular helper cells in lung adenocarcinoma is associated with mutational load by Enfield, Katey S.S., Ng, Kevin W., Marshall, Erin A., Martin, Spencer D., Lam, Wan L.

“…Abstract Tertiary lymphoid organs are ectopic lymphoid formations found in inflamed tissues such as tumors, and their presence has been associated with…”
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Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma by Enfield, Katey S. S., Marshall, Erin A., Anderson, Christine, Ng, Kevin W., Rahmati, Sara, Xu, Zhaolin, Fuller, Megan, Milne, Katy, Lu, Daniel, Shi, Rocky, Rowbotham, David A., Becker-Santos, Daiana D., Johnson, Fraser D., English, John C., MacAulay, Calum E., Lam, Stephen, Lockwood, William W., Chari, Raj, Karsan, Aly, Jurisica, Igor, Lam, Wan L.

“…Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumor suppressor in many epithelial…”
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Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response by Sage, Adam P., Ng, Kevin W., Marshall, Erin A., Stewart, Greg L., Minatel, Brenda C., Enfield, Katey S. S., Martin, Spencer D., Brown, Carolyn J., Abraham, Ninan, Lam, Wan L.

“…The tumour immune microenvironment is a crucial mediator of lung tumourigenesis, and characterizing the immune landscape of patient tumours may guide…”
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Abstract PR11: Hyperspectral imaging tools capture the spatial organization of cell subsets within the tumor microenvironment by Enfield, Katey S.S., Martin, Spencer D., Kung, Sonia H.Y., Gallagher, Paul, MacAulay, Calum E., Guillaud, Martial, Lam, Wan L.

“…Abstract Immune cells are a major component of the tumor microenvironment (TME). The spatial organization of immune cell subpopulations within the TME is…”
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Abstract A04: Altered expression of lncRNAs overlapping pseudogene loci as an alternative mechanism of cancer gene regulation by Stewart, Greg L., Enfield, Katey S.S., Martinez, Victor D., Marshall, Erin A., Lam, Stephen, Lam, Wan L.

“…Abstract The advent of next-generation sequencing has begun to reveal the functional importance of long noncoding RNAs (lncRNAs) in human cell biology, which…”
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Molecular features in arsenic-induced lung tumors by Hubaux, Roland, Becker-Santos, Daiana D, Enfield, Katey Ss, Rowbotham, David, Lam, Stephen, Lam, Wan L, Martinez, Victor D

“…Arsenic is a well-known human carcinogen, which potentially affects ~160 million people worldwide via exposure to unsafe levels in drinking water. Lungs are…”
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Abstract B36: Novel miRNAs as tissue-of-origin markers for distinguishing malignant pleural mesothelioma from lung adenocarcinoma by Marshall, Erin A., Anderson, Christine, Ng, Kevin W., Minatel, Brenda C., Enfield, Katey S.S., Sage, Adam P., Xu, Zhaolin, Lam, Wan L., Martinez, Victor D.

“…Abstract The outcome of patients with malignant pleural mesothelioma (MPM) is poor, and diagnosis is complicated by a lack of biomarkers capable of…”
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