Search Results - "Endy, Drew"

Rewritable digital data storage in live cells via engineered control of recombination directionality by Bonnet, Jerome, Subsoontorn, Pakpoom, Endy, Drew

“…The use of synthetic biological systems in research, healthcare, and manufacturing often requires autonomous history-dependent behavior and therefore some form…”
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Amplifying Genetic Logic Gates by Bonnet, Jerome, Yin, Peter, Ortiz, Monica E., Subsoontorn, Pakpoom, Endyt, Drew

“…Organisms must process information encoded via developmental and environmental signals to survive and reproduce. Researchers have also engineered synthetic…”
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Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza by Abbott, Timothy R., Dhamdhere, Girija, Liu, Yanxia, Lin, Xueqiu, Goudy, Laine, Zeng, Leiping, Chemparathy, Augustine, Chmura, Stephen, Heaton, Nicholas S., Debs, Robert, Pande, Tara, Endy, Drew, La Russa, Marie F., Lewis, David B., Qi, Lei S.

“…The coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-2 virus, has highlighted the need for antiviral approaches that can target emerging…”
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Precise and reliable gene expression via standard transcription and translation initiation elements by Mutalik, Vivek K, Guimaraes, Joao C, Cambray, Guillaume, Lam, Colin, Christoffersen, Marc Juul, Mai, Quynh-Anh, Tran, Andrew B, Paull, Morgan, Keasling, Jay D, Arkin, Adam P, Endy, Drew

“…By using a bicistronic design, with a leader peptide that overlaps with and contains the Shine-Dalgarno site for a downstream gene of interest, the authors…”
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Fail-safe genetic codes designed to intrinsically contain engineered organisms by Calles, Jonathan, Justice, Isaac, Brinkley, Detravious, Garcia, Alexa, Endy, Drew

“…Abstract One challenge in engineering organisms is taking responsibility for their behavior over many generations. Spontaneous mutations arising before or…”
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Composability of regulatory sequences controlling transcription and translation in Escherichia coli by Kosuri, Sriram, Goodman, Daniel B., Cambray, Guillaume, Mutalik, Vivek K., Gao, Yuan, Arkin, Adam P., Endy, Drew, Church, George M.

“…The inability to predict heterologous gene expression levels precisely hinders our ability to engineer biological systems. Using well-characterized regulatory…”
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Determination of cell fate selection during phage lambda infection by St-Pierre, François, Endy, Drew

“…Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes. For example, some cells lyse whereas others survive as lysogens…”
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Measurements of translation initiation from all 64 codons in E. coli by Hecht, Ariel, Glasgow, Jeff, Jaschke, Paul R, Bawazer, Lukmaan A, Munson, Matthew S, Cochran, Jennifer R, Endy, Drew, Salit, Marc

“…Our understanding of translation underpins our capacity to engineer living systems. The canonical start codon (AUG) and a few near-cognates (GUG, UUG) are…”
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Engineering tRNA abundances for synthetic cellular systems by Maheshwari, Akshay J., Calles, Jonathan, Waterton, Sean K., Endy, Drew

“…Routinizing the engineering of synthetic cells requires specifying beforehand how many of each molecule are needed. Physics-based tools for estimating desired…”
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Engineering BioBrick vectors from BioBrick parts by Shetty, Reshma P, Endy, Drew, Knight, Jr, Thomas F

“…The underlying goal of synthetic biology is to make the process of engineering biological systems easier. Recent work has focused on defining and developing…”
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Genome-wide transcription response of Staphylococcus epidermidis to heat shock and medically relevant glucose levels by Benjamin, Kaisha N, Goyal, Aditi, Nair, Ramesh V, Endy, Drew

“…Skin serves as both barrier and interface between body and environment. Skin microbes are intermediaries evolved to respond, transduce, or act in response to…”
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The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology by Galdzicki, Michal, Clancy, Kevin P, Oberortner, Ernst, Pocock, Matthew, Quinn, Jacqueline Y, Rodriguez, Cesar A, Roehner, Nicholas, Wilson, Mandy L, Adam, Laura, Anderson, J Christopher, Bartley, Bryan A, Beal, Jacob, Chandran, Deepak, Chen, Joanna, Densmore, Douglas, Endy, Drew, Grünberg, Raik, Hallinan, Jennifer, Hillson, Nathan J, Johnson, Jeffrey D, Kuchinsky, Allan, Lux, Matthew, Misirli, Goksel, Peccoud, Jean, Plahar, Hector A, Sirin, Evren, Stan, Guy-Bart, Villalobos, Alan, Wipat, Anil, Gennari, John H, Myers, Chris J, Sauro, Herbert M

“…The synthetic biology research community describes a standard language for exchanging designs of biological 'parts'. The re-use of previously validated designs…”
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Growing a circular economy with fungal biotechnology: a white paper by Meyer, Vera, Basenko, Evelina Y, Benz, J Philipp, Braus, Gerhard H, Caddick, Mark X, Csukai, Michael, de Vries, Ronald P, Endy, Drew, Frisvad, Jens C, Gunde-Cimerman, Nina, Haarmann, Thomas, Hadar, Yitzhak, Hansen, Kim, Johnson, Robert I, Keller, Nancy P, Kraševec, Nada, Mortensen, Uffe H, Perez, Rolando, Ram, Arthur F J, Record, Eric, Ross, Phil, Shapaval, Volha, Steiniger, Charlotte, van den Brink, Hans, van Munster, Jolanda, Yarden, Oded, Wösten, Han A B

“…Fungi have the ability to transform organic materials into a rich and diverse set of useful products and provide distinct opportunities for tackling the urgent…”
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Quantitative estimation of activity and quality for collections of functional genetic elements by Mutalik, Vivek K, Guimaraes, Joao C, Cambray, Guillaume, Mai, Quynh-Anh, Christoffersen, Marc Juul, Martin, Lance, Yu, Ayumi, Lam, Colin, Rodriguez, Cesar, Bennett, Gaymon, Keasling, Jay D, Endy, Drew, Arkin, Adam P

“…This linear ANOVA-based method quantifies the activity of different combinations of genetic elements and assigns a score that indicates the variation in…”
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A fully decompressed synthetic bacteriophage øX174 genome assembled and archived in yeast by Jaschke, Paul R, Lieberman, Erica K, Rodriguez, Jon, Sierra, Adrian, Endy, Drew

“…Abstract The 5386 nucleotide bacteriophage øX174 genome has a complicated architecture that encodes 11 gene products via overlapping protein coding sequences…”
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Colloidal Physics Modeling Reveals How Per-Ribosome Productivity Increases with Growth Rate in Escherichia coli by Maheshwari, Akshay J, Sunol, Alp M, Gonzalez, Emma, Endy, Drew, Zia, Roseanna N

“…Faster-growing cells must synthesize proteins more quickly. Increased ribosome abundance only partly accounts for increases in total protein synthesis rates…”
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Engineered cell-cell communication via DNA messaging by Ortiz, Monica E, Endy, Drew

“…Evolution has selected for organisms that benefit from genetically encoded cell-cell communication. Engineers have begun to repurpose elements of natural…”
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Measuring the activity of BioBrick promoters using an in vivo reference standard by Kelly, Jason R, Rubin, Adam J, Davis, Joseph H, Ajo-Franklin, Caroline M, Cumbers, John, Czar, Michael J, de Mora, Kim, Glieberman, Aaron L, Monie, Dileep D, Endy, Drew

“…The engineering of many-component, synthetic biological systems is being made easier by the development of collections of reusable, standard biological parts…”
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Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery by Ghosh, Debadyuti, Kohli, Aditya G, Moser, Felix, Endy, Drew, Belcher, Angela M

“…M13 bacteriophage is a well-characterized platform for peptide display. The utility of the M13 display platform is derived from the ability to encode phage…”
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Author Correction: Reconstruction of cysteine biosynthesis using engineered cysteine-free enzymes by Fujishima, Kosuke, Wang, Kendrick M., Palmer, Jesse A., Abe, Nozomi, Nakahigashi, Kenji, Endy, Drew, Rothschild, Lynn J.

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
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