Search Results - "Endutkin, Anton"

Requirements for DNA bubble structure for efficient cleavage by helix–two-turn–helix DNA glycosylases by Makasheva, Kristina A, Endutkin, Anton V, Zharkov, Dmitry O

“…Abstract Oxidative DNA lesions, constantly generated by both endogenous and environmentally induced reactive oxygen species, are removed via the base excision…”
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A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system by Yudkina, Anna V, Endutkin, Anton V, Diatlova, Evgeniia A, Zharkov, Dmitry O

“…Oxidative damage is a major source of genomic instability in all organisms with the aerobic metabolism. 8-Oxoguanine (8-oxoG), an abundant oxidized purine, is…”
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Dynamics of 8‑Oxoguanine in DNA: Decisive Effects of Base Pairing and Nucleotide Context by Ovcherenko, Sergey S., Shernyukov, Andrey V., Nasonov, Dmitry M., Endutkin, Anton V., Zharkov, Dmitry O., Bagryanskaya, Elena G.

“…8-Oxo-7,8-dihydroguanine (oxoG), an abundant DNA lesion, can mispair with adenine and induce mutations. To prevent this, cells possess DNA repair glycosylases…”
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DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus by Endutkin, Anton V., Panferova, Elena P., Barmatov, Alexander E., Zharkov, Dmitry O.

“…•Fpg and MutY from S. aureus NCTC 8325 lab strain and Fpg from a multidrug-resistant C0673 isolate have been characterized.•Both Fpg homologs excise…”
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Effect of DNA Methylation on the 3′→5′ Exonuclease Activity of Major Human Abasic Site Endonuclease APEX1 by Endutkin, Anton V., Yatsenko, Darya D., Zharkov, Dmitry O.

“…Apurinic/apyrimidinic (AP) endonucleases are the key enzymes in the DNA base excision repair, as they hydrolyze the phosphodiester bond in the AP site formed…”
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Recognition of a Clickable Abasic Site Analog by DNA Polymerases and DNA Repair Enzymes by Endutkin, Anton V., Yudkina, Anna V., Zharkov, Timofey D., Kim, Daria V., Zharkov, Dmitry O.

“…Azide–alkyne cycloaddition (“click chemistry”) has found wide use in the analysis of molecular interactions in living cells…”
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Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1 by Bazlekowa-Karaban, Milena, Prorok, Paulina, Baconnais, Sonia, Taipakova, Sabira, Akishev, Zhiger, Zembrzuska, Dominika, Popov, Alexander V., Endutkin, Anton V., Groisman, Regina, Ishchenko, Alexander A., Matkarimov, Bakhyt T., Bissenbaev, Amangeldy, Le Cam, Eric, Zharkov, Dmitry O., Tudek, Barbara, Saparbaev, Murat

“…[Display omitted] •APE1 forms a stable complex with ssDNA longer than 15 mer;•APE1-catalyzed repair and TF-stimulating activities depend on the structure of…”
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Inhibitors of DNA Glycosylases as Prospective Drugs by Mechetin, Grigory V, Endutkin, Anton V, Diatlova, Evgeniia A, Zharkov, Dmitry O

“…DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from…”
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Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1 by Kim, Daria V, Diatlova, Evgeniia A, Zharkov, Timofey D, Melentyev, Vasily S, Yudkina, Anna V, Endutkin, Anton V, Zharkov, Dmitry O

“…Apurinic/apyrimidinic (AP) sites are abundant DNA lesions generated both by spontaneous base loss and as intermediates of base excision DNA repair. In human…”
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Critical Sites of DNA Backbone Integrity for Damaged Base Removal by Formamidopyrimidine–DNA Glycosylase by Endutkin, Anton V, Zharkov, Dmitry O

“…DNA glycosylases, the enzymes that initiate base excision DNA repair, recognize damaged bases through a series of precisely orchestrated movements. Most…”
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Probing the Conformational Restraints of DNA Damage Recognition with β-L-Nucleotides by Yudkina, Anna V, Kim, Daria V, Zharkov, Timofey D, Zharkov, Dmitry O, Endutkin, Anton V

“…The DNA building blocks 2'-deoxynucleotides are enantiomeric, with their natural β-D-configuration dictated by the sugar moiety. Their synthetic…”
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Base Excision DNA Repair in Plants: Arabidopsis and Beyond by Grin, Inga R., Petrova, Daria V., Endutkin, Anton V., Ma, Chunquan, Yu, Bing, Li, Haiying, Zharkov, Dmitry O.

“…Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living organisms from damage caused by both intrinsic and environmental factors…”
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DNA Deformation-Coupled Recognition of 8‑Oxoguanine: Conformational Kinetic Gating in Human DNA Glycosylase by Li, Haoquan, Endutkin, Anton V, Bergonzo, Christina, Fu, Lin, Grollman, Arthur, Zharkov, Dmitry O, Simmerling, Carlos

“…8-Oxoguanine (8-oxoG), a mutagenic DNA lesion generated under oxidative stress, differs from its precursor guanine by only two substitutions (O8 and H7). Human…”
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Reading and Misreading 8-oxoguanine, a Paradigmatic Ambiguous Nucleobase by Yudkina, Anna, Shilkin, Evgeniy, Endutkin, Anton, Makarova, Alena, Zharkov, Dmitry

“…7,8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual coding properties. It forms both Watson–Crick (anti)oxoG:(anti)C and…”
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Characterizing Aptamer Interaction with the Oncolytic Virus VV-GMCSF-Lact by Dymova, Maya A, Malysheva, Daria O, Popova, Victoria K, Dmitrienko, Elena V, Endutkin, Anton V, Drokov, Danil V, Mukhanov, Vladimir S, Byvakina, Arina A, Kochneva, Galina V, Artyushenko, Polina V, Shchugoreva, Irina A, Rogova, Anastasia V, Tomilin, Felix N, Kichkailo, Anna S, Richter, Vladimir A, Kuligina, Elena V

“…Aptamers are currently being investigated for their potential to improve virotherapy. They offer several advantages, including the ability to prevent the…”
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Noncatalytic Domains in DNA Glycosylases by Torgasheva, Natalia A., Diatlova, Evgeniia A., Grin, Inga R., Endutkin, Anton V., Mechetin, Grigory V., Vokhtantsev, Ivan P., Yudkina, Anna V., Zharkov, Dmitry O.

“…Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic…”
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Correlated Target Search by Vaccinia Virus Uracil-DNA Glycosylase, a DNA Repair Enzyme and a Processivity Factor of Viral Replication Machinery by Diatlova, Evgeniia A, Mechetin, Grigory V, Yudkina, Anna V, Zharkov, Vasily D, Torgasheva, Natalia A, Endutkin, Anton V, Shulenina, Olga V, Konevega, Andrey L, Gileva, Irina P, Shchelkunov, Sergei N, Zharkov, Dmitry O

“…The protein encoded by the vaccinia virus gene has base excision repair uracil-DNA -glycosylase (vvUNG) activity and also acts as a processivity factor in the…”
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Transient protein-protein complexes in base excision repair by Endutkin, Anton V., Yudkina, Anna V., Sidorenko, Viktoriya S., Zharkov, Dmitry O.

“…Transient protein-protein complexes are of great importance for organizing multiple enzymatic reactions into productive reaction pathways. Base excision repair…”
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8-Oxoguanine Affects DNA Backbone Conformation in the EcoRI Recognition Site and Inhibits Its Cleavage by the Enzyme by Hoppins, Joanna J, Gruber, David R, Miears, Heather L, Kiryutin, Alexey S, Kasymov, Rustem D, Petrova, Darya V, Endutkin, Anton V, Popov, Alexander V, Yurkovskaya, Alexandra V, Fedechkin, Stanislav O, Brockerman, Jacob A, Zharkov, Dmitry O, Smirnov, Serge L

“…8-oxoguanine is one of the most abundant and impactful oxidative DNA lesions. However, the reasons underlying its effects, especially those not directly…”
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Molecular dynamics approach to identification of new OGG1 cancer-associated somatic variants with impaired activity by Popov, Aleksandr V., Endutkin, Anton V., Yatsenko, Darya D., Yudkina, Anna V., Barmatov, Alexander E., Makasheva, Kristina A., Raspopova, Darya Yu, Diatlova, Evgeniia A., Zharkov, Dmitry O.

“…DNA of living cells is always exposed to damaging factors. To counteract the consequences of DNA lesions, cells have evolved several DNA repair systems, among…”
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