Search Results - "Endocrinology (Philadelphia)"

Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications: Potential Role of Alterations in Mitochondrial Function in the Pathogenesis of Insulin Resistance and Type 2 Diabetes by Sangwung, Panjamaporn, Petersen, Kitt Falk, Shulman, Gerald I, Knowles, Joshua W

“…Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is present in most prediabetic (preDM) individuals. Insulin resistance…”
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GLP-1 Receptor Expression Within the Human Heart by Baggio, Laurie L, Yusta, Bernardo, Mulvihill, Erin E, Cao, Xiemin, Streutker, Catherine J, Butany, Jagdish, Cappola, Thomas P, Margulies, Kenneth B, Drucker, Daniel J

“…Abstract Glucagonlike peptide-1 receptor (GLP-1R) agonists, which are used to treat type 2 diabetes and obesity, reduce the rates of myocardial infarction and…”
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Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society by Zoeller, R. Thomas, Brown, T. R, Doan, L. L, Gore, A. C, Skakkebaek, N. E, Soto, A. M, Woodruff, T. J, Vom Saal, F. S

“…An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential…”
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Prenatal Stress, Glucocorticoids, and Developmental Programming of the Stress Response by McGowan, Patrick O, Matthews, Stephen G

“…The early environment has a major impact on the developing embryo, fetus, and infant. Parental adversity (maternal and paternal) and glucocorticoid exposure…”
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Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals by Egusquiza, Riann Jenay, Blumberg, Bruce

“…Abstract The incidence of obesity has reached an all-time high, and this increase is observed worldwide. There is a growing need to understand all the factors…”
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Obesity, Neuroinflammation, and Reproductive Function by Lainez, Nancy M, Coss, Djurdjica

“…The increasing occurrence of obesity has become a significant public health concern. Individuals with obesity have higher prevalence of heart disease, stroke,…”
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Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish by Qiu, Wenhui, Zhao, Yali, Yang, Ming, Farajzadeh, Matthew, Pan, Chenyuan, Wayne, Nancy L

“…Bisphenol A (BPA) is a well-known environmental, endocrine-disrupting chemical, and bisphenol S (BPS) has been considered a safer alternative for BPA-free…”
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Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health by Bansal, Amita, Henao-Mejia, Jorge, Simmons, Rebecca A

“…Abstract The incidence of metabolic disorders like type 2 diabetes and obesity continues to increase. In addition to the well-known contributors to these…”
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New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation by Vandevyver, Sofie, Dejager, Lien, Tuckermann, Jan, Libert, Claude

“…Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of numerous (autoimmune) inflammatory diseases. They exert their actions by…”
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The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance by Oosterman, Johanneke E, Wopereis, Suzan, Kalsbeek, Andries

“…Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to…”
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Sex and gender differences in anticancer treatment toxicity - a call for revisiting drug dosing in oncology by Özdemir, Berna C, Gerard, Camille L, Espinosa da Silva, Cristina

“…The practice of oncology has dramatically changed in the last decade with the introduction of molecular tumor profiling into routine tumor diagnostics and the…”
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CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential by Schlaepfer, Isabel R, Joshi, Molishree

“…Abstract Energy homeostasis during fasting or prolonged exercise depends on mitochondrial fatty acid oxidation (FAO). This pathway is crucial in many tissues…”
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Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia by Cawthorn, William P, Scheller, Erica L, Parlee, Sebastian D, Pham, H. An, Learman, Brian S, Redshaw, Catherine M. H, Sulston, Richard J, Burr, Aaron A, Das, Arun K, Simon, Becky R, Mori, Hiroyuki, Bree, Adam J, Schell, Benjamin, Krishnan, Venkatesh, MacDougald, Ormond A

“…Bone marrow adipose tissue (MAT) accounts for up to 70% of bone marrow volume in healthy adults and increases further in clinical conditions of altered…”
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Nuclear Androgen Receptor Regulates Testes Organization and Oocyte Maturation in Zebrafish by Crowder, Camerron M, Lassiter, Christopher S, Gorelick, Daniel A

“…Abstract Androgens act through the nuclear androgen receptor (AR) to regulate gonad differentiation and development. In mice, AR is necessary for…”
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Insulin and Glucagon: Partners for Life by Holst, Jens Juul, Holland, William, Gromada, Jesper, Lee, Young, Unger, Roger H., Yan, Hai, Sloop, Kyle W., Kieffer, Timothy J., Damond, Nicolas, Herrera, Pedro L.

“…Is glucagon essential for the hyperglycemia in insulin deficiency, as suggested by experimental glucagon antagonism? No, sufficient levels of basal insulin…”
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How UV Light Touches the Brain and Endocrine System Through Skin, and Why by Slominski, Andrzej T, Zmijewski, Michal A, Plonka, Przemyslaw M, Szaflarski, Jerzy P, Paus, Ralf

“…Abstract The skin, a self-regulating protective barrier organ, is empowered with sensory and computing capabilities to counteract the environmental stressors…”
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Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes by Mauvais-Jarvis, Franck, Klein, Sabra L, Levin, Ellis R

“…Abstract Severe outcomes and death from the novel coronavirus disease 2019 (COVID-19) appear to be characterized by an exaggerated immune response with…”
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The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism by Adlanmerini, Marine, Lazar, Mitchell A

“…Abstract REV-ERB nuclear receptors are potent transcriptional repressors that play an important role in the core mammalian molecular clock and metabolism…”
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Minireview: Obesity and Breast Cancer: The Estrogen Connection by CLEARY, Margot P, GROSSMANN, Michael E

“…There is now substantial evidence that overweight and/or obesity and/or weight gain are risk factors for the development of postmenopausal breast cancer. In…”
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Free Fatty Acid Receptor GPR120 Is Highly Expressed in Enteroendocrine K Cells of the Upper Small Intestine and Has a Critical Role in GIP Secretion After Fat Ingestion by Iwasaki, Kanako, Harada, Norio, Sasaki, Kazuki, Yamane, Shunsuke, Iida, Keiko, Suzuki, Kazuyo, Hamasaki, Akihiro, Nasteska, Daniela, Shibue, Kimitaka, Joo, Erina, Harada, Takanari, Hashimoto, Toshihiro, Asakawa, Yoshinori, Hirasawa, Akira, Inagaki, Nobuya

“…Gastric inhibitory polypeptide (GIP) is an incretin secreted from enteroendocrine K cells in response to meal ingestion. Recently free fatty acid receptor G…”
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