Effects of restricted feeding on blood parameters in pregnant rabbits

Effects of restricted feeding on blood parameters in pregnant rabbits

The effects of restricted feeding (20 g/day from gestational day (GD) 6 to 28) on pregnancy outcome and blood parameters were examined in pregnant rabbits. As compared with the group which was allowed free access to diet throughout the gestational period (NT group), the group subjected to restricted...

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Bibliographic Details
Published in:Journal of toxicological sciences Vol. 34; no. 1; pp. 129 - 137
Main Authors: Matsuoka, Tetsuya, Mizuguchi, Hiroyasu, Mizoguchi, Yasumoto, Endho, Takako, Kamata, Ryo, Fukuda, Kazuya, Ishikawa, Tsutomu, Asano, Yuzo
Format: Journal Article
Language:English
Published: Japan The Japanese Society of Toxicology 01-02-2009
Japan Science and Technology Agency
Subjects:
Abortion
Abortion, Veterinary - blood
Animals
Blood Chemical Analysis - methods
Blood Chemical Analysis - statistics & numerical data
Blood coagulation
Blood Coagulation - physiology
Blood Coagulation Factors - analysis
Blood Coagulation Tests - methods
Blood Coagulation Tests - statistics & numerical data
Blood parameters
Cesarean Section - veterinary
Female
Food Deprivation
Gestational Age
Pregnancy
Pregnancy Outcome
Pregnancy, Animal - blood
Pregnant rabbits
Progesterone - blood
Progesterone concentration
Rabbits
Restricted feeding
Time Factors
Weight Gain
Weight Loss
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Summary:The effects of restricted feeding (20 g/day from gestational day (GD) 6 to 28) on pregnancy outcome and blood parameters were examined in pregnant rabbits. As compared with the group which was allowed free access to diet throughout the gestational period (NT group), the group subjected to restricted feeding (R group) showed significantly lower values in many parameters such as total protein, albumin and triglyceride on GDs 22 and 28, reflecting low nutritive conditions. In addition, there were significant changes in blood coagulation-related parameters, suggesting an imbalance between coagulation and anti-coagulation factors. Moreover, abortions occurred in about half of the animals of the R group between GDs 23 and 27. When aborted rabbits were compared with those which could maintain pregnancy under restricted feeding, total protein, albumin, platelets and antithrombin III values and especially blood progesterone concentration were significantly lower in aborted rabbits on GD 22, prior to occurrence of abortion. These results suggested that abortions due to restricted feeding might be brought about by lower nutritive conditions, an imbalance of blood coagulation-related factors and lower blood progesterone concentrations.
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ISSN:0388-1350
1880-3989
DOI:10.2131/jts.34.129