High-Dose Intramuscular Triamcinolone in Severe, Chronic, Life-Threatening Asthma

THE majority of patients with asthma have mild symptoms that can be controlled with beta-2 agonists, cromolyn, theophylline, inhaled corticosteroids, or a combination of these agents. Systemic corticosteroids are often required during acute exacerbations. A small percentage of patients, however, hav...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 324; no. 9; pp. 585 - 589
Main Authors:	Ogirala, Raja G, Aldrich, Thomas K, Prezant, David J, Sinnett, Mark J, Enden, Jay B, Williams, M. Henry
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 28-02-1991
Subjects:	Administration, Oral Adult Airway management Allergies Asthma Asthma - drug therapy Asthma - physiopathology Biological and medical sciences Chronic Disease Chronic obstructive pulmonary disease Corticosteroids Diabetes Double-Blind Method Drug dosages Drug therapy Emergency medical care Female Follow-Up Studies Forced Expiratory Volume Hospitalization Humans Hypertension Injections, Intramuscular Intensive care Male Mechanical ventilation Medical sciences Middle Aged Patients Peak Expiratory Flow Rate Pharmacology. Drug treatments Prednisone Prednisone - administration & dosage Prednisone - therapeutic use Respiratory system Side effects Steroids Triamcinolone - administration & dosage Triamcinolone - adverse effects Triamcinolone - therapeutic use Ventilation Ventilators Human Steroid Respiratory disease Antiinflammatory agent Oral administration Prednisone Intramuscular administration Asthma Chemotherapy Chronic Treatment Triamcinolone High dose
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Summary:	THE majority of patients with asthma have mild symptoms that can be controlled with beta-2 agonists, cromolyn, theophylline, inhaled corticosteroids, or a combination of these agents. Systemic corticosteroids are often required during acute exacerbations. A small percentage of patients, however, have severe and even life-threatening asthma. This group is characterized by long-term dependency on steroids, frequent emergency room visits, recurrent hospitalizations, and often a history of requiring mechanical ventilation. Despite treatment with systemic steroids, these patients are forced to modify their lifestyle to adapt to their chronic, disabling shortness of breath. Methotrexate, 1 , 2 gold, 3 , 4 troleandomycin, 5 , 6 and a moderate monthly dose . . .
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM199102283240903