Search Results - "Encinas, Juan M."

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus by Encinas, Juan M., Michurina, Tatyana V., Peunova, Natalia, Park, June-Hee, Tordo, Julie, Peterson, Daniel A., Fishell, Gord, Koulakov, Alex, Enikolopov, Grigori

“…Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous…”
Get full text

Fluoxetine Targets Early Progenitor Cells in the Adult Brain by Encinas, Juan M., Vaahtokari, Anne, Enikolopov, Grigori

“…Chronic treatment with antidepressants increases neurogenesis in the adult hippocampus. This increase in the production of new neurons may be required for the…”
Get full text

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis by Sierra, Amanda, Encinas, Juan M., Deudero, Juan J.P., Chancey, Jessica H., Enikolopov, Grigori, Overstreet-Wadiche, Linda S., Tsirka, Stella E., Maletic-Savatic, Mirjana

“…In the adult hippocampus, neuroprogenitor cells in the subgranular zone (SGZ) of the dentate gyrus give rise to newborn neuroblasts. However, only a small…”
Get full text

Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis by Sierra, Amanda, Martín-Suárez, Soraya, Valcárcel-Martín, Roberto, Pascual-Brazo, Jesús, Aelvoet, Sarah-Ann, Abiega, Oihane, Deudero, Juan J., Brewster, Amy L., Bernales, Irantzu, Anderson, Anne E., Baekelandt, Veerle, Maletić-Savatić, Mirjana, Encinas, Juan M.

“…Adult hippocampal neurogenesis is believed to maintain a range of cognitive functions, many of which decline with age. We recently reported that radial neural…”
Get full text

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling by Abiega, Oihane, Beccari, Sol, Diaz-Aparicio, Irune, Nadjar, Agnes, Layé, Sophie, Leyrolle, Quentin, Gómez-Nicola, Diego, Domercq, María, Pérez-Samartín, Alberto, Sánchez-Zafra, Víctor, Paris, Iñaki, Valero, Jorge, Savage, Julie C, Hui, Chin-Wai, Tremblay, Marie-Ève, Deudero, Juan J P, Brewster, Amy L, Anderson, Anne E, Zaldumbide, Laura, Galbarriatu, Lara, Marinas, Ainhoa, Vivanco, Maria dM, Matute, Carlos, Maletic-Savatic, Mirjana, Encinas, Juan M, Sierra, Amanda

“…Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory and autoimmune diseases, but its role in the diseased brain is…”
Get full text

Perspective: Of Mice and Men – How Widespread Is Adult Neurogenesis? by Petrik, David, Encinas, Juan M.

“…These are exciting times for research on adult hippocampal neurogenesis (AHN). Debate and controversy regarding the existence of generation of new neurons in…”
Get full text

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis by Comeau, Samuel, Encinas, Juan M., Diaz-Aparicio, Irune, Beccari, Sol, Sierra, Amanda, Tremblay, Marie-Ève

“…Microglia cells are the major orchestrator of the brain inflammatory response. As such, they are traditionally studied in various contexts of trauma, injury,…”
Get full text

Intermediate Progenitors in Adult Hippocampal Neurogenesis: Tbr2 Expression and Coordinate Regulation of Neuronal Output by Hodge, Rebecca D, Kowalczyk, Thomas D, Wolf, Susanne A, Encinas, Juan M, Rippey, Caitlin, Enikolopov, Grigori, Kempermann, Gerd, Hevner, Robert F

“…Neurogenesis in the adult hippocampus is a highly regulated process that originates from multipotent progenitors in the subgranular zone (SGZ). Currently,…”
Get full text

BASP1 labels neural stem cells in the neurogenic niches of mammalian brain by Manganas, Louis N., Durá, Irene, Osenberg, Sivan, Semerci, Fatih, Tosun, Mehmet, Mishra, Rachana, Parkitny, Luke, Encinas, Juan M., Maletic-Savatic, Mirjana

“…The mechanisms responsible for determining neural stem cell fate are numerous and complex. To begin to identify the specific components involved in these…”
Get full text

Genetic approaches identify adult pituitary stem cells by Gleiberman, Anatoli S, Michurina, Tatyana, Encinas, Juan M, Roig, Jose L, Krasnov, Peter, Balordi, Francesca, Fishell, Gord, Rosenfeld, Michael G, Enikolopov, Grigori

“…Adult tissues undergo continuous cell turnover in response to stress, damage, or physiological demand. New differentiated cells are generated from dedicated or…”
Get full text

Author Correction: BASP1 labels neural stem cells in the neurogenic niches of mammalian brain by Manganas, Louis N., Durá, Irene, Osenberg, Sivan, Semerci, Fatih, Tosun, Mehmet, Mishra, Rachana, Parkitny, Luke, Encinas, Juan M., Maletic‑Savatic, Mirjana

Get full text

Adult human neurogenesis: from microscopy to magnetic resonance imaging by Sierra, Amanda, Encinas, Juan M, Maletic-Savatic, Mirjana

“…Neural stem cells reside in well-defined areas of the adult human brain and are capable of generating new neurons throughout the life span. In rodents, it is…”
Get full text

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments by Satta, Valentina, Alonso, Cristina, Díez, Paula, Martín-Suárez, Soraya, Rubio, Marta, Encinas, Juan M, Fernández-Ruiz, Javier, Sagredo, Onintza

“…Dravet syndrome (DS) is an epileptic syndrome caused by mutations in the gene encoding the α1 subunit of the sodium channel Nav1.1, which is associated with…”
Get full text

The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis by Pineda, José R, Encinas, Juan M

“…Adult hippocampal neurogenesis is a highly plastic process that responds swiftly to neuronal activity. Adult hippocampal neurogenesis can be regulated at the…”
Get full text

Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures by Bielefeld, Pascal, Schouten, Marijn, Meijer, Guido M, Breuk, Marit J, Geijtenbeek, Karlijne, Karayel, Sedef, Tiaglik, Alisa, Vuuregge, Anna H, Willems, Ruth A L, Witkamp, Diede, Lucassen, Paul J, Encinas, Juan M, Fitzsimons, Carlos P

“…Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone…”
Get full text

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling by Abiega, Oihane, Beccari, Sol, Diaz-Aparicio, Irune, Nadjar, Agnes, Layé, Sophie, Leyrolle, Quentin, Gómez-Nicola, Diego, Domercq, María, Pérez-Samartín, Alberto, Sánchez-Zafra, Víctor, Paris, Iñaki, Valero, Jorge, Savage, Julie C, Hui, Chin-Wai, Tremblay, Marie-Ève, Deudero, Juan J P, Brewster, Amy L, Anderson, Anne E, Zaldumbide, Laura, Galbarriatu, Lara, Marinas, Ainhoa, Vivanco, Maria dM, Matute, Carlos, Maletic-Savatic, Mirjana, Encinas, Juan M, Sierra, Amanda

“…[This corrects the article DOI: 10.1371/journal.pbio.1002466.]…”
Get full text

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling by Abiega, Oihane, Beccari, Sol, Diaz-Aparicio, Irune, Nadjar, Agnes, Layé, Sophie, Leyrolle, Quentin, Gómez-Nicola, Diego, Domercq, María, Pérez-Samartín, Alberto, Sánchez-Zafra, Víctor, Paris, Iñaki, Valero, Jorge, Savage, Julie C, Hui, Chin-Wai, Tremblay, Marie-Ève, Deudero, Juan J P, Brewster, Amy L, Anderson, Anne E, Zaldumbide, Laura, Galbarriatu, Lara, Marinas, Ainhoa, Vivanco, Maria dM, Matute, Carlos, Maletic-Savatic, Mirjana, Encinas, Juan M, Sierra, Amanda

“…[This corrects the article DOI: 10.1371/journal.pbio.1002466.]…”
Get full text

Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis by Encinas, Juan M., Sierra, Amanda

“…► The adult hippocampal neurogenic output is determined at different levels. ► The neurogenic output declines with age. ► A depletion of activated neural stem…”
Get full text

Expression of nestin–green fluorescent protein transgene marks oval cells in the adult liver by Gleiberman, Anatoli S., Encinas, Juan M., Mignone, John L., Michurina, Tatyana, Rosenfeld, Michael G., Enikolopov, Grigori

“…Oval cells, which become apparent in the liver after chronic injury, serve as bipotent progenitors for differentiated hepatocytes and cholangiocytes. We found…”
Get full text

Neurogenic hippocampal targets of deep brain stimulation by Encinas, Juan M., Hamani, Clement, Lozano, Andres M., Enikolopov, Grigori

“…Deep brain stimulation (DBS) is being used to treat movement, neurological, and psychiatric disorders; recently it has been successfully applied to patients…”
Get full text