Search Results - "Emson, Piers C."

Reduced Vesicular Storage of Dopamine Causes Progressive Nigrostriatal Neurodegeneration by Caudle, W. Michael, Richardson, Jason R, Wang, Min Z, Taylor, Tonya N, Guillot, Thomas S, McCormack, Alison L, Colebrooke, Rebecca E, Di Monte, Donato A, Emson, Piers C, Miller, Gary W

“…The vesicular monoamine transporter 2 (VMAT2; SLC18A2) is responsible for packaging dopamine into vesicles for subsequent release and has been suggested to…”
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Localization of LRRK2 to membranous and vesicular structures in mammalian brain by Biskup, Saskia, Moore, Darren J., Celsi, Fulvio, Higashi, Shinji, West, Andrew B., Andrabi, Shaida A., Kurkinen, Kaisa, Yu, Seong-Woon, Savitt, Joseph M., Waldvogel, Henry J., Faull, Richard L. M., Emson, Piers C., Torp, Reidun, Ottersen, Ole P., Dawson, Ted M., Dawson, Valina L.

“…Objective The PARK8 gene responsible for late‐onset autosomal dominant Parkinson's disease encodes a large novel protein of unknown biological function termed…”
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Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein by Allen, Bridget, Ingram, Esther, Takao, Masaki, Smith, Michael J, Jakes, Ross, Virdee, Kanwar, Yoshida, Hirotaka, Holzer, Max, Craxton, Molly, Emson, Piers C, Atzori, Cristiana, Migheli, Antonio, Crowther, R. Anthony, Ghetti, Bernardino, Spillantini, Maria Grazia, Goedert, Michel

“…The identification of mutations in the Tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has made it possible to express…”
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Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I‐CT100 transgenic mice, an Alzheimer's disease model by Jeong, Yun Ha, Park, Cheol Hyoung, Yoo, Jongman, Shin, Ki Young, Ahn, Sung‐Min, Kim, Hye‐Sun, Lee, Sang Hyung, Emson, Piers C., Suh, Yoo‐Hun

“…ABSTRACT Although chronic stress is known to be linked with memory and other neurological disorders, little is known about the relationship between chronic…”
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Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis by Guillot, Thomas S, Shepherd, Kennie R, Richardson, Jason R, Wang, Min Z, Li, Yingjie, Emson, Piers C, Miller, Gary W

“…The vesicular monoamine transporter 2 (VMAT2) controls the loading of dopamine (DA) into vesicles and therefore determines synaptic properties such as quantal…”
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Glutamate Uptake is Reduced in Prefrontal Cortex in Huntington’s Disease by Hassel, Bjørnar, Tessler, Shoshi, Faull, Richard L. M., Emson, Piers C.

“…Huntington’s disease (HD) is caused by a CAG repeat expansion in the HD gene, but how this mutation causes neuronal dysfunction and degeneration is unclear…”
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Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain by Higashi, Shinji, Moore, Darren J, Colebrooke, Rebecca E, Biskup, Saskia, Dawson, Valina L, Arai, Heii, Dawson, Ted M, Emson, Piers C

“…Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been identified as the cause of familial Parkinson's disease (PD) at the PARK8 locus…”
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Localization of Parkinson’s disease-associated LRRK2 in normal and pathological human brain by Higashi, Shinji, Biskup, Saskia, West, Andrew B, Trinkaus, Daniel, Dawson, Valina L, Faull, Richard L.M, Waldvogel, Henry J, Arai, Heii, Dawson, Ted M, Moore, Darren J, Emson, Piers C

“…Abstract Mutations in the LRRK2 gene cause autosomal dominant, late-onset parkinsonism, which presents with pleomorphic pathology including…”
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Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice by Helyes, Zsuzsanna, Pintér, Erika, Sándor, Katalin, Elekes, Krisztián, Bánvölgyi, Ágnes, Keszthelyi, Dániel, Szőke, Éva, Tóth, Dániel M, Sándor, Zoltán, Kereskai, László, Pozsgai, Gábor, Allen, Jeremy P, Emson, Piers C, Markovics, Adrienn, Szolcsányi, János

“…We have shown that somatostatin released from activated capsaicin-sensitive nociceptive nerve endings during inflammatory processes elicits systemic…”
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Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease by Brooks, Wendy M, Lynch, Patrick J, Ingle, Catherine C, Hatton, Alexander, Emson, Piers C, Faull, Richard L.M, Starkey, Mike P

“…Abstract The successfully functioning brain is a heavy user of metabolic energy. Alzheimer's disease, in which cognitive faculties decline, may be due, at…”
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Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease by Higashi, Shinji, Moore, Darren J, Yamamoto, Ryoko, Minegishi, Michiko, Sato, Kiyoshi, Togo, Takashi, Katsuse, Omi, Uchikado, Hirotake, Furukawa, Yoshiko, Hino, Hiroaki, Kosaka, Kenji, Emson, Piers C, Wada, Keiji, Dawson, Valina L, Dawson, Ted M, Arai, Heii, Iseki, Eizo

“…Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common causes of both familial and sporadic forms of Parkinson disease and are…”
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Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease by Colebrooke, Rebecca E., Humby, Trevor, Lynch, Patrick J., McGowan, Daniel P., Xia, Jing, Emson, Piers C.

“…Dopamine cytotoxicity is thought to contribute towards the selective loss of substantia nigra pars compacta dopamine neurons and disease progression in…”
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Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains by Iritani, Shuji, Niizato, Kazuhiro, Nawa, Hiroyuki, Ikeda, Kenji, Emson, Piers C.

“…Recently, the pathogenesis of schizophrenia has been investigated from the perspective of neurodevelopmental dysfunction theory. On the other hand, it has been…”
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Growth-Associated Protein GAP-43 and L1 Act Synergistically to Promote Regenerative Growth of Purkinje Cell Axons in vivo by Zhang, Yi, Xuenong Bo, Schoepfer, Ralf, Anthony J. D. G. Holtmaat, Joost Verhaagen, Emson, Piers C., A. Robert Lieberman, Patrick N. Anderson

“…Neuronal expression of growth-associated protein 43 (GAP-43) and the cell adhesion molecule L1 has been correlated with CNS axonal growth and regeneration, but…”
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Gene Expression Analysis in Schizophrenia: Reproducible up-Regulation of Several Members of the Apolipoprotein L Family Located in a High-Susceptibility Locus for Schizophrenia on Chromosome 22 by Mimmack, Michael L., Ryan, Margaret, Baba, Hajime, Navarro-Ruiz, Juani, Iritani, Shuji, Richard L. M. Faull, McKenna, Peter J., Jones, Peter B., Arai, Heii, Starkey, Michael, Emson, Piers C., Bahn, Sabine

“…We screened a custom-made candidate gene cDNA array comprising 300 genes. Genes chosen have either been implicated in schizophrenia, make conceptual sense in…”
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A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma by Giudici, Maria-Luisa, Emson, Piers C, Irvine, Robin F

“…Type I PIPkins (phosphatidylinositol 4-phosphate 5-kinases) are the enzymes that catalyse the major cellular route of synthesis of PtdIns(4,5) P2, and three…”
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Immunological Function in Mice Lacking the Rac-Related GTPase RhoG by Vigorito, Elena, Bell, Sarah, Hebeis, Barbara J., Reynolds, Helen, McAdam, Simon, Emson, Piers C., McKenzie, Andrew, Turner, Martin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Presynaptic control of striatal dopamine neurotransmission in adult vesicular monoamine transporter 2 (VMAT2) mutant mice by Patel, Jyoti, Mooslehner, Katrin A., Chan, Pok Man, Emson, Piers C., Stamford, Jonathan A.

“…The vesicular monoamine transporter 2 (VMAT2) plays a pivotal role in regulating the size of vesicular and cytosolic dopamine (DA) storage pools within the…”
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Advances in the molecular understanding of GABAB receptors by Billinton, Andrew, Ige, Antoinette O, Bolam, J.Paul, White, Julia H, Marshall, Fiona H, Emson, Piers C

“…The molecular nature of the metabotropic GABAB receptor was for some time a mystery, however it was recently discovered that two related G-protein-coupled…”
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GABA(B) receptors: structure and function by Emson, Piers C

“…In the basal ganglia the effects of gamma-aminobutyrate (GABA) are mediated by both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors. Although the…”
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