Search Results - "Emsley, R"

How can clinical trials expedite the process of answering treatment-related questions and reduce the number of participants needed? by Emsley, R

“…Patients and the research community need better and more cost-effective randomised trials. These are the ‘gold standard’ way of seeing if a new treatment works…”
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Psoriasis treat to target: defining outcomes in psoriasis using data from a real‐world, population‐based cohort study (the British Association of Dermatologists Biologics and Immunomodulators Register, BADBIR) by Mahil, S.K., Wilson, N., Dand, N., Reynolds, N.J., Griffiths, C.E.M., Emsley, R., Marsden, A., Evans, I., Warren, R.B., Stocken, D., Barker, J.N., Burden, A.D., Smith, C.H.

“…Summary Background The ‘treat to target’ paradigm improves outcomes and reduces costs in chronic disease management but is not yet established in psoriasis…”
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Social media and its relationship with mood, self‐esteem and paranoia in psychosis by Berry, N., Emsley, R., Lobban, F., Bucci, S.

“…Objective An evidence‐base is emerging indicating detrimental and beneficial effects of social media. Little is known about the impact of social media use on…”
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C.06.01 The treatment continuum in schizophrenia from the acute phase to maintenance by Emsley, R

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C.12.01 The nature of relapse in schizophrenia by Emsley, R

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Routine hospital management of self-harm and risk of further self-harm: propensity score analysis using record-based cohort data by Steeg, S, Emsley, R, Carr, M, Cooper, J, Kapur, N

“…The care received by people presenting to hospital following self-harm varies and it is unclear how different types of treatment affect risk of further…”
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An experience sampling study of worry and rumination in psychosis by Hartley, S, Haddock, G, Vasconcelos E Sa, D, Emsley, R, Barrowclough, C

“…Increasing research effort is being dedicated to investigating the links between emotional processes and psychosis, despite the traditional demarcation between…”
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Sex versus gender associations with depressive symptom trajectories over 24 months in first-episode schizophrenia spectrum disorders by Luckhoff, H.K., del Re, E.C., Smit, R., Kilian, S., Phahladira, L., Emsley, R., Asmal, L.

“…Females with schizophrenia often experience more severe and persistent depressive symptoms than males, in particular during the acute phase of the illness. In…”
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Psychotherapy of Biases in Cognition in Schizophrenia: the SlowMo Randomised Controlled Trial for Paranoia, Outcomes and Mechanisms by Garety, P., Ward, T., Emsley, R., Greenwood, K., Hardy, A.

“…Reasoning biases, specifically jumping to conclusions and belief inflexibility, may play a causal role in persistent paranoia. SlowMo, a new digitally…”
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Placebo-controlled trial of agomelatine in the treatment of major depressive disorder by Kennedy, S.H., Emsley, R.

“…The efficacy and safety of flexible dosing with the antidepressant agomelatine (25–50 mg/day) was evaluated in a 6-week, double-blind, randomized,…”
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Brain volume changes over the first year of treatment in schizophrenia: relationships to antipsychotic treatment by Emsley, R, Asmal, L, du Plessis, S, Chiliza, B, Phahladira, L, Kilian, S

“…Progressive brain volume reductions have been described in schizophrenia, and an association with antipsychotic exposure has been reported. We compared…”
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Childhood adversity and cognitive function in schizophrenia spectrum disorders and healthy controls: evidence for an association between neglect and social cognition by Kilian, S, Asmal, L, Chiliza, B, Olivier, M R, Phahladira, L, Scheffler, F, Seedat, S, Marder, S R, Green, M F, Emsley, R

“…Childhood adversity is associated with cognitive impairments in schizophrenia. However, findings to date are inconsistent and little is known about the…”
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Sex versus gender associations with brain structure by Luckhoff, H.K., Smit, R., Phahladira, L., du Plessis, Emsley, R., Asmal, L.

“…•Sex vs. gender associations with brain structure were examined in adults (n = 88)•Gender was assessed using the Bem Sex Role Inventory.•Sex, but not gender,…”
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Sex, gender, and outcome in first-episode psychosis: The role of premorbid functioning by Luckhoff, H.K., Asmal, L., Smit, R., Phahladira, L., Emsley, R., del Re, E.C.

“…•The associations of sex and gender with treatment outcomes in FES were assessed.•Lower masculinity scores predicted worse disorganized symptom…”
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Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study by Warren, R.B., Marsden, A., Tomenson, B., Mason, K.J., Soliman, M.M., Burden, A.D., Reynolds, N.J., Stocken, D., Emsley, R., Griffiths, C.E.M., Smith, C.

“…Summary Background Biologic therapies have revolutionized the treatment of moderate‐to‐severe psoriasis. However, for reasons largely unknown, many patients do…”
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Weight gain and metabolic change as predictors of symptom improvement in first-episode schizophrenia spectrum disorder patients treated over 12 months by Luckhoff, H., Phahladira, L., Scheffler, F., Asmal, L., du Plessis, S., Chiliza, B., Kilian, S., Emsley, R.

“…Treatment-emergent weight gain is associated with antipsychotic efficacy in schizophrenia patients treated with clozapine and olanzapine. However, few studies…”
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Fronto-limbic white matter fractional anisotropy and body mass index in first-episode schizophrenia spectrum disorder patients compared to healthy controls by Luckhoff, H.K., du Plessis, S., Scheffler, F., Phahladira, L., Kilian, S., Buckle, C., Smit, R., Chiliza, B., Asmal, L., Emsley, R.

“…•BMI is lower in first-episode schizophrenia patients compared to controls.•Increased BMI correlates with lower fronto-limbic white matter FA in…”
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The UK AVATAR 1 and 2 Trials for People with Distressing Voices – Findings and Learning from AVATAR1, and AVATAR2 Developments in Theory and Therapy by Craig, T., Garety, P., Ward, T., Edwards, C., Rus-Calafell, M., Huckvale, M., Emsley, R.

“…Introduction Many people suffering from psychotic disorders report persistent auditory verbal hallucinations (‘voices’) despite pharmacological and…”
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Factors Moderating the Relationship Between Childhood Trauma and Premorbid Adjustment in First-Episode Schizophrenia by Kilian, S, Burns, J K, Seedat, S, Asmal, L, Chiliza, B, Du Plessis, S, Olivier, M R, Kidd, M, Emsley, R

“…Childhood trauma is a recognised risk factor for schizophrenia. It has been proposed that childhood trauma interferes with normal neurodevelopment, thereby…”
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Cognitive performance during the first year of treatment in first-episode schizophrenia: a case-control study by Olivier, M R, Killian, S, Chiliza, B, Asmal, L, Schoeman, R, Oosthuizen, P P, Kidd, M, Emsley, R

“…Several questions remain unanswered regarding the magnitude and time course of cognitive improvement in response to antipsychotic treatment. The purpose of…”
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