Search Results - "Emschermann, Frederic"

Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis by Sauter, Reinhard J, Sauter, Manuela, Reis, Edimara S, Emschermann, Frederic N, Nording, Henry, Ebenhöch, Sonja, Kraft, Peter, Münzer, Patrick, Mauler, Maximilian, Rheinlaender, Johannes, Madlung, Johannes, Edlich, Frank, Schäffer, Tilman E, Meuth, Sven G, Dürschmied, Daniel, Geisler, Tobias, Borst, Oliver, Gawaz, Meinrad, Kleinschnitz, Christoph, Lambris, John D, Langer, Harald F

“…BACKGROUND:Platelets have distinct roles in the vascular system in that they are the major mediator of thrombosis, critical for restoration of tissue…”
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Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
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Platelet-Derived PCSK9 Is Associated with LDL Metabolism and Modulates Atherothrombotic Mechanisms in Coronary Artery Disease by Petersen-Uribe, Álvaro, Kremser, Marcel, Rohlfing, Anne-Katrin, Castor, Tatsiana, Kolb, Kyra, Dicenta, Valerie, Emschermann, Frederic, Li, Bo, Borst, Oliver, Rath, Dominik, Müller, Karin Anne Lydia, Gawaz, Meinrad Paul

“…Platelets play a significant role in atherothrombosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is critically involved in the regulation of LDL…”
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The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets by Nording, Henry, Baron, Lasse, Haberthür, David, Emschermann, Frederic, Mezger, Matthias, Sauter, Manuela, Sauter, Reinhard, Patzelt, Johannes, Knoepp, Kai, Nording, Anne, Meusel, Moritz, Meyer-Saraei, Roza, Hlushchuk, Ruslan, Sedding, Daniel, Borst, Oliver, Eitel, Ingo, Karsten, Christian M., Feil, Robert, Pichler, Bernd, Erdmann, Jeanette, Verschoor, Admar, Chavakis, Emmanouil, Chavakis, Triantafyllos, von Hundelshausen, Philipp, Köhl, Jörg, Gawaz, Meinrad, Langer, Harald F.

“…Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified…”
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Platelet SR-PSOX/CXCL16-CXCR6 Axis Influences Thrombotic Propensity and Prognosis in Coronary Artery Disease by Guan, Tianyun, Emschermann, Frederic, Schories, Christoph, Groga-Bada, Patrick, Martus, Peter, Borst, Oliver, Gawaz, Meinrad, Geisler, Tobias, Rath, Dominik, Chatterjee, Madhumita

“…Platelets express the transmembrane chemokine SR-PSOX/CXCL16, proteolytic cleavage of which generates the sCXCL16 soluble-(s) chemokine. The sCXCL16 engages…”
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Protocol to isolate and analyze mouse bone marrow derived dendritic cells (BMDC) by Sauter, Manuela, Sauter, Reinhard J., Nording, Henry, Olbrich, Marcus, Emschermann, Frederic, Langer, Harald F.

“…Different types of immune cells are involved in atherogenesis and may act atheroprotective or atheroprogressive. Here, we describe an in vitro approach to…”
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Characterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation by Nestele, Jeremy A, Rohlfing, Anne-Katrin, Dicenta, Valerie, Bild, Alexander, Eißler, Daniela, Emschermann, Frederic, Kremser, Marcel, Krutzke, Konstantin, Schäffer, Tilman E, Borst, Oliver, Levi, Moran, Korin, Netanel, Gawaz, Meinrad Paul

“…Traditional antithrombotic agents commonly share a therapy-limiting side effect, as they increase the overall systemic bleeding risk. A novel approach for…”
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The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis by Heinzmann, David, Bangert, Anna, Müller, Anna-Maria, von Ungern-Sternberg, Saskia N I, Emschermann, Frederic, Schönberger, Tanja, Chatterjee, Madhumita, Mack, Andreas F, Klingel, Karin, Kandolf, Reinhard, Malesevic, Miroslav, Borst, Oliver, Gawaz, Meinrad, Langer, Harald F, Katus, Hugo, Fischer, Gunter, May, Andreas E, Kaya, Ziya, Seizer, Peter

“…Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in…”
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Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi by Rohde, Jörg, Emschermann, Frederic, Knittler, Michael R, Rziha, Hanns-Joachim

“…The Orf virus (ORFV), a zoonotic Parapoxvirus, causes pustular skin lesions in small ruminants (goat and sheep). Intriguingly, ORFV can repeatedly infect its…”
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Resistance to renal denervation therapy — Identification of underlying mechanisms by analysis of differential DNA methylation by Emschermann, Frederic, Zuern, Christine S., Patzelt, Johannes, Rizas, Konstantinos D., Jäger, Günter, Eick, Christian, Meuth, Sven G., Gawaz, Meinrad, Bauer, Axel, Langer, Harald F.

“…Factors causing resistance to renal denervation (RDN) for treatment of arterial hypertension are not known. In the current study, we sought to determine…”
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Platelet ACKR3/CXCR7 favors antiplatelet lipids over an atherothrombotic lipidome and regulates thromboinflammation by Cebo, Malgorzata, Dittrich, Kristina, Fu, Xiaoqing, Manke, Mailin C., Emschermann, Frederic, Rheinlaender, Johannes, von Eysmondt, Hendrik, Ferreirós, Nerea, Sudman, Jessica, Witte, Alexander, Pelzl, Lisann, Borst, Oliver, Geisler, Tobias, Rath, Dominik, Bakchoul, Tamam, Gawaz, Meinrad, Schäffer, Tilman E., Lämmerhofer, Michael, Chatterjee, Madhumita

“…Platelet ACKR3/CXCR7 surface expression is enhanced and influences prognosis in coronary artery disease (CAD) patients, who exhibit a distinct atherothrombotic…”
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Risk assessment in COVID‐19: Prognostic importance of cardiovascular parameters by Zdanyte, Monika, Martus, Peter, Nestele, Jeremy, Bild, Alexander, Mizera, Lars, Glatthaar, Andreas, Petersen Uribe, Álvaro, Emschermann, Frederic, Henes, Jessica‐Kristin, Geisler, Tobias, Müller, Karin, Gawaz, Meinrad, Rath, Dominik

“…Background Cardiovascular risk factors and comorbidities are highly prevalent among COVID‐19 patients and are associated with worse outcomes. Hypothesis We…”
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Anaphylatoxin receptor C3aR on platelets participates in platelet function and links innate immunity with thrombosis by Sauter, Reinhard Joerg, Sauter, Manuela, Reis, Edimara S., Emschermann, Frederic, Nording, Henry, Kraft, Peter, Mauler, Maximilian, Muenzer, Patrick, Rheinlaender, Johannes, Edlich, Frank, Schäffer, Tilman E, Meuth, Sven G, Duerschmied, Daniel, Borst, Oliver, Kleinschnitz, Christoph, Lambris, John D, Langer, Harald

“…Abstract Background Beyond the superficial function of blood coagulation, platelets play an important role in the genesis of vascular inflammatory processes…”
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Binding of Oxidized Low-Density Lipoprotein on Circulating Platelets Is increased in Patients With Acute Coronary Syndromes and Induces Platelet Adhesion to Vascular Wall In Vivo—Brief Report by Stellos, Konstantinos, Sauter, Reinhard, Fahrleitner, Manuela, Grimm, Juliane, Stakos, Dimitrios, Emschermann, Frederic, Panagiota, Victoria, Gnerlich, Stephan, Perk, Annegret, Schönberger, Tanja, Bigalke, Boris, Langer, Harald F, Gawaz, Meinrad

“…OBJECTIVE—Hyperlipidemia is associated with platelet hyperactivity. In the present study, we evaluated the binding of oxidized low-density lipoprotein (oxLDL)…”
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Platelet bound oxLDL shows an inverse correlation with plasma anaphylatoxin C5a in patients with coronary artery disease by Nording, Henry, Giesser, Annika, Patzelt, Johannes, Sauter, Reinhard, Emschermann, Frederic, Stellos, Konstantinos, Gawaz, Meinrad, Langer, Harald F.

“…Both oxidized lipids as well as the complement system contribute to atherothrombosis. The expression of complement receptors correlates with the expression of…”
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Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease by Rath, Dominik, Rapp, Vera, Schwartz, Jessica, Winter, Stefan, Emschermann, Frederic, Arnold, Daniel, Rheinlaender, Johannes, Büttcher, Manuela, Strebl, Michael, Braun, Michael B, Altgelt, Konstanze, Uribe, Álvaro Petersen, Schories, Christoph, Canjuga, Denis, Schaeffeler, Elke, Borst, Oliver, Schäffer, Tilman E, Langer, Harald, Stehle, Thilo, Schwab, Matthias, Geisler, Tobias, Gawaz, Meinrad, Chatterjee, Madhumita

“…Genetic predisposition through single-nucleotide variation (SNV) influences circulatory soluble junctional adhesion molecule-A (sJAM-A) levels in coronary…”
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Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation by Rath, Dominik, Rapp, Vera, Schwartz, Jessica, Winter, Stefan, Emschermann, Frederic, Arnold, Daniel, Rheinlaender, Johannes, Büttcher, Manuela, Strebl, Michael, Braun, Michael B., Altgelt, Konstanze, Uribe, Álvaro Petersen, Schories, Christoph, Canjuga, Denis, Schaeffeler, Elke, Borst, Oliver, Schäffer, Tilman E., Langer, Harald, Stehle, Thilo, Schwab, Matthias, Geisler, Tobias, Gawaz, Meinrad, Chatterjee, Madhumita

“…[Display omitted] •Genetic predisposition through F11R-SNVs determine circulatory sJAM-A levels in CAD patients. Homozygous carriers of the minor…”
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Activated Platelets Upregulate β2 Integrin Mac-1 (CD11b/CD18) on Dendritic Cells, Which Mediates Heterotypic Cell–Cell Interaction by Nording, Henry, Sauter, Manuela, Lin, Chaolan, Steubing, Rebecca, Geisler, Sven, Sun, Ying, Niethammer, Joel, Emschermann, Fréderic, Wang, Yunmei, Zieger, Barbara, Nieswandt, Bernhard, Kleinschnitz, Christoph, Simon, Daniel I., Langer, Harald F.

“…Abstract Recent evidence suggests interaction of platelets with dendritic cells (DCs), while the molecular mechanisms mediating this heterotypic cell…”
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Activated Platelets Upregulate β 2 Integrin Mac-1 (CD11b/CD18) on Dendritic Cells, Which Mediates Heterotypic Cell-Cell Interaction by Nording, Henry, Sauter, Manuela, Lin, Chaolan, Steubing, Rebecca, Geisler, Sven, Sun, Ying, Niethammer, Joel, Emschermann, Fréderic, Wang, Yunmei, Zieger, Barbara, Nieswandt, Bernhard, Kleinschnitz, Christoph, Simon, Daniel I, Langer, Harald F

“…Recent evidence suggests interaction of platelets with dendritic cells (DCs), while the molecular mechanisms mediating this heterotypic cell cross-talk are…”
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