Search Results - "Emr, Scott"

Membrane Protein Quality Control Mechanisms in the Endo-Lysosome System by Sardana, Richa, Emr, Scott D.

“…Protein quality control (PQC) machineries play a critical role in selective identification and removal of mistargeted, misfolded, and aberrant proteins. This…”
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The ESCRT Pathway by Henne, William M., Buchkovich, Nicholas J., Emr, Scott D.

“…Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport)…”
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The Endosomal Sorting Complex ESCRT-II Mediates the Assembly and Architecture of ESCRT-III Helices by Henne, William Mike, Buchkovich, Nicholas J., Zhao, Yingying, Emr, Scott D.

“…The endosomal sorting complexes required for transport (ESCRTs) constitute hetero-oligomeric machines that mediate topologically similar membrane-sculpting…”
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ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology by Manford, Andrew G., Stefan, Christopher J., Yuan, Helen L., MacGurn, Jason A., Emr, Scott D.

“…Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane…”
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Ubiquitin and Membrane Protein Turnover: From Cradle to Grave by MacGurn, Jason A, Hsu, Pi-Chiang, Emr, Scott D

“…From the moment of cotranslational insertion into the lipid bilayer of the endoplasmic reticulum (ER), newly synthesized integral membrane proteins are subject…”
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ER–PM connections: sites of information transfer and inter-organelle communication by Stefan, Christopher J, Manford, Andrew G, Emr, Scott D

“…Eukaryotic cells are divided into distinct membrane-bound organelles with unique identities and specialized metabolic functions. Communication between…”
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Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane by Sardana, Richa, Zhu, Lu, Emr, Scott D

“…Maintenance of organelle identity is profoundly dependent on the coordination between correct targeting of proteins and removal of mistargeted and damaged…”
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TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor by MacGurn, Jason A., Hsu, Pi-Chiang, Smolka, Marcus B., Emr, Scott D.

“…The TORC1 kinase signaling complex is a key determinant of cell growth that senses nutritional status and responds by coordinating diverse cellular processes…”
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Membrane protein recycling from the vacuole/lysosome membrane by Suzuki, Sho W, Emr, Scott D

“…The lysosome (or vacuole in yeast) is the central organelle responsible for cellular degradation and nutrient storage. Lysosomes receive cargo from the…”
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ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins by Zhu, Lu, Jorgensen, Jeff R, Li, Ming, Chuang, Ya-Shan, Emr, Scott D

“…The lysosome plays an important role in maintaining cellular nutrient homeostasis. Regulation of nutrient storage can occur by the ubiquitination of certain…”
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Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites by Stefan, Christopher J., Manford, Andrew G., Baird, Daniel, Yamada-Hanff, Jason, Mao, Yuxin, Emr, Scott D.

“…Sac1 phosphoinositide (PI) phosphatases are essential regulators of PI-signaling networks. Yeast Sac1, an integral endoplasmic reticulum (ER) membrane protein,…”
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Ubiquitin-Dependent Lysosomal Membrane Protein Sorting and Degradation by Li, Ming, Rong, Yueguang, Chuang, Ya-Shan, Peng, Dan, Emr, Scott D.

“…As an essential organelle in the cell, the lysosome is responsible for digestion and recycling of intracellular components, storage of nutrients, and pH…”
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Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation by Teis, David, Saksena, Suraj, Emr, Scott D.

“…The sequential action of the Vps27/HRS complex, ESCRT-I, -II, and -III is required to sort ubiquitinated transmembrane proteins to the lumen of lysosomes via…”
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Molecular mechanisms of the membrane sculpting ESCRT pathway by Henne, William Mike, Stenmark, Harald, Emr, Scott D

“…The endosomal sorting complexes required for transport (ESCRT) drive multivesicular body (MVB) biogenesis and cytokinetic abscission. Originally identified…”
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Essential N-Terminal Insertion Motif Anchors the ESCRT-III Filament during MVB Vesicle Formation by Buchkovich, Nicholas J., Henne, William Mike, Tang, Shaogeng, Emr, Scott D.

“…The endosomal sorting complexes required for transport (ESCRTs) have emerged as key cellular machinery that drive topologically unique membrane deformation and…”
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Coming together to define membrane contact sites by Scorrano, Luca, De Matteis, Maria Antonietta, Emr, Scott, Giordano, Francesca, Hajnóczky, György, Kornmann, Benoît, Lackner, Laura L., Levine, Tim P., Pellegrini, Luca, Reinisch, Karin, Rizzuto, Rosario, Simmen, Thomas, Stenmark, Harald, Ungermann, Christian, Schuldiner, Maya

“…Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane…”
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Molecular mechanisms of inter-organelle ER–PM contact sites by Henne, W Mike, Liou, Jen, Emr, Scott D

“…Observed for decades by electron microscopy but mostly ignored, inter-organelle membrane contact sites (MCSs) are now emerging as major sites for the exchange…”
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Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex by Guiney, Evan L, Klecker, Till, Emr, Scott D

“…Targeted endocytosis of plasma membrane (PM) proteins allows cells to adjust their complement of membrane proteins to changing extracellular conditions. For a…”
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Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins by Li, Ming, Koshi, Tatsuhiro, Emr, Scott D

“…Cells must regulate the abundance and activity of numerous nutrient transporters in different organelle membranes to achieve nutrient homeostasis. As the…”
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Design principles of the ESCRT-III Vps24-Vps2 module by Banjade, Sudeep, Shah, Yousuf H, Tang, Shaogeng, Emr, Scott D

“…ESCRT-III polymerization is required for all endosomal sorting complex required for transport (ESCRT)-dependent events in the cell. However, the relative…”
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