Search Results - "Emoto, Noriaki"

Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis by Honda, Sakiko, Ikeda, Koji, Urata, Ryota, Yamazaki, Ekura, Emoto, Noriaki, Matoba, Satoaki

“…Senescent vascular cells are detected in atherosclerotic lesion, and its involvement in the development of atherosclerosis has been revealed; however, whether…”
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Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype by Barinda, Agian Jeffilano, Ikeda, Koji, Nugroho, Dhite Bayu, Wardhana, Donytra Arby, Sasaki, Naoto, Honda, Sakiko, Urata, Ryota, Matoba, Satoaki, Hirata, Ken-ichi, Emoto, Noriaki

“…Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally…”
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An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension by Ryanto, Gusty R. T., Ikeda, Koji, Miyagawa, Kazuya, Tu, Ly, Guignabert, Christophe, Humbert, Marc, Fujiyama, Tomoyuki, Yanagisawa, Masashi, Hirata, Ken-ichi, Emoto, Noriaki

“…Pulmonary arterial hypertension is a progressive fatal disease that is characterized by pathological pulmonary artery remodeling, in which endothelial cell…”
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Inactivating the Uninhibited: The Tale of Activins and Inhibins in Pulmonary Arterial Hypertension by Ryanto, Gusty Rizky Teguh, Musthafa, Ahmad, Hara, Tetsuya, Emoto, Noriaki

“…Advances in technology and biomedical knowledge have led to the effective diagnosis and treatment of an increasing number of rare diseases. Pulmonary arterial…”
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GPNMB plays a protective role against obesity-related metabolic disorders by reducing macrophage inflammatory capacity by Prabata, Adam, Ikeda, Koji, Rahardini, Elda Putri, Hirata, Ken-Ichi, Emoto, Noriaki

“…Obesity is a global health problem that is often related to cardiovascular and metabolic diseases. Chronic low-grade inflammation in white adipose tissue (WAT)…”
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Endothelial Cell―Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition by WIDYANTORO, Bambang, EMOTO, Noriaki, KISANUKI, Yaz Y, YANAGISAWA, Masashi, HIRATA, Ken-Ichi, NAKAYAMA, Kazuhiko, ANGGRAHINI, Dyah W, ADIARTO, Suko, IWASA, Naoko, YAGI, Keiko, MIYAGAWA, Kazuya, RIKITAKE, Yoshiyuki, SUZUKI, Takashi

“…Persistently high plasma endothelin-1 (ET-1) levels in diabetic patients have been associated with the development of cardiac fibrosis, which results from the…”
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Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going by Haryono, Andreas, Ramadhiani, Risa, Ryanto, Gusty Rizky Teguh, Emoto, Noriaki

“…Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two…”
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Efficacy of Right Ventricular Free-Wall Longitudinal Speckle-Tracking Strain for Predicting Long-Term Outcome in Patients With Pulmonary Hypertension by Motoji, Yoshiki, Tanaka, Hidekazu, Fukuda, Yuko, Ryo, Keiko, Emoto, Noriaki, Kawai, Hiroya, Hirata, Ken-ichi

“…Background: The development of right ventricular (RV) dysfunction in pulmonary hypertension (PH) patients is associated with adverse outcome, so that the…”
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In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma by Taniguchi, Seiji, Matsui, Takahiro, Kimura, Kenji, Funaki, Soichiro, Miyamoto, Yu, Uchida, Yutaka, Sudo, Takao, Kikuta, Junichi, Hara, Tetsuya, Motooka, Daisuke, Liu, Yu-Chen, Okuzaki, Daisuke, Morii, Eiichi, Emoto, Noriaki, Shintani, Yasushi, Ishii, Masaru

“…Alveolar macrophages (AMs) are crucial for maintaining normal lung function. They are abundant in lung cancer tissues, but their pathophysiological…”
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Chondroitin sulfate mediates liver responses to injury induced by dual endothelin receptor inhibition by Ryanto, Gusty Rizky Teguh, Yorifuji, Kennosuke, Ikeda, Koji, Emoto, Noriaki

“…Although dual endothelin receptor antagonists (ERAs) show great promise for treating various conditions, their propensity to induce liver injury limits their…”
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Multi-Institutional Prospective Cohort Study of Patients With Pulmonary Hypertension Associated With Respiratory Diseases by Tanabe, Nobuhiro, Kumamaru, Hiraku, Tamura, Yuichi, Taniguchi, Hiroyuki, Emoto, Noriaki, Yamada, Yoshihito, Nishiyama, Osamu, Tsujino, Ichizo, Kuraishi, Hiroshi, Nishimura, Yoshihiro, Kimura, Hiroshi, Inoue, Yoshikazu, Morio, Yoshiteru, Nakatsumi, Yasuto, Satoh, Toru, Hanaoka, Masayuki, Kusaka, Kei, Sumitani, Mitsuhiro, Handa, Tomohiro, Sakao, Seiicihiro, Kimura, Tomoki, Kondoh, Yasuhiro, Nakayama, Kazuhiko, Tanaka, Kensuke, Ohira, Hiroshi, Nishimura, Masaharu, Miyata, Hiroaki, Tatsumi, Koichiro, Group, for the JRPHS

“…Background:There is limited evidence for pulmonary arterial hypertension (PAH)-targeted therapy in patients with pulmonary hypertension associated with…”
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Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction by Shimizu, Kotaro, Kikuta, Junichi, Ohta, Yumi, Uchida, Yutaka, Miyamoto, Yu, Morimoto, Akito, Yari, Shinya, Sato, Takashi, Kamakura, Takefumi, Oshima, Kazuo, Imai, Ryusuke, Liu, Yu-Chen, Okuzaki, Daisuke, Hara, Tetsuya, Motooka, Daisuke, Emoto, Noriaki, Inohara, Hidenori, Ishii, Masaru

“…Cholesteatoma, which potentially results from tympanic membrane retraction, is characterized by intractable local bone erosion and subsequent hearing loss and…”
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Publisher Correction: Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype by Barinda, Agian Jeffilano, Ikeda, Koji, Nugroho, Dhite Bayu, Wardhana, Donytra Arby, Sasaki, Naoto, Honda, Sakiko, Urata, Ryota, Matoba, Satoaki, Hirata, Ken-ichi, Emoto, Noriaki

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension by Miyagawa, Kazuya, Emoto, Noriaki

“…Endothelin 1 (ET-1), a potent vasoconstrictive substance, was discovered in 1988 by Yanagisawa and colleagues, and since then, a quarter of a century has…”
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Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition by Rinastiti, Pranindya, Ikeda, Koji, Rahardini, Elda Putri, Miyagawa, Kazuya, Tamada, Naoki, Kuribayashi, Yuko, Hirata, Ken-Ichi, Emoto, Noriaki

“…Pulmonary hypertension is a progressive lung disease with poor prognosis due to the consequent right heart ventricular failure. Pulmonary artery remodeling and…”
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ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy by Adiarto, Suko, Heiden, Susi, Vignon-Zellweger, Nicolas, Nakayama, Kazuhiko, Yagi, Keiko, Yanagisawa, Masashi, Emoto, Noriaki

“…Hypertensive patients develop cardiac hypertrophy and fibrosis with increased stiffness, contractile deficit and altered perfusion. Angiotensin II (AngII) is…”
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Utility of Right Ventricular Free Wall Speckle-Tracking Strain for Evaluation of Right Ventricular Performance in Patients with Pulmonary Hypertension by Fukuda, Yuko, MD, Tanaka, Hidekazu, MD, PhD, Sugiyama, Daisuke, MD, PhD, Ryo, Keiko, MD, Onishi, Tetsuari, MD, PhD, Fukuya, Hiroyuki, MD, PhD, Nogami, Munenobu, MD, PhD, Ohno, Yoshiharu, MD, PhD, Emoto, Noriaki, MD, PhD, Kawai, Hiroya, MD, PhD, Hirata, Ken-ichi, MD, PhD

“…Background The objectives of this study were to test the utility of right ventricular (RV) speckle-tracking strain as an assessment tool for RV function in…”
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Effects of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension on remodeling in right-sided heart by Sumimoto, Keiko, Tanaka, Hidekazu, Mukai, Jun, Yamashita, Kentaro, Tanaka, Yusuke, Shono, Ayu, Suzuki, Makiko, Yokota, Shun, Suto, Makiko, Takada, Hiroki, Matsumoto, Kensuke, Taniguchi, Yu, Emoto, Noriaki, Hirata, Ken-ichi

“…Remodeling in the right-sided heart plays an important role in the management of pulmonary hypertension (PH) patients. However, the effect of balloon pulmonary…”
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An electrocardiographic score to predict pulmonary hypertension in children with atrial septal defect by Murni, Indah K, Kato, Taichi, Wirawan, Muhammad Taufik, Arafuri, Nadya, Hermawan, Kristia, Hartopo, Anggoro Budi, Anggrahini, Dyah Wulan, Nugroho, Sasmito, Noormanto, Noormanto, Emoto, Noriaki, Dinarti, Lucia Kris

“…In limited resource settings, identification of factors that predict the occurrence of pulmonary hypertension(PH) in children with atrial septal defect(ASD) is…”
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Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis by Nugroho, Dhite Bayu, Ikeda, Koji, Kajimoto, Kazuaki, Hirata, Ken-ichi, Emoto, Noriaki

“…Obesity often causes systemic metabolic disorders in close association with adipose tissue dysfunction. Adipose tissue contains well-developed vasculatures,…”
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