Search Results - "Emmick, J T"

Dual effect of suramin on calcium fluxes across sarcoplasmic reticulum vesicle membranes by Emmick, J T, Kwon, S, Bidasee, K R, Besch, K T, Besch, Jr, H R

“…Suramin is a polysulfonated naphthylurea developed originally to treat trypanosomiasis. This drug has gained considerable attention recently as an effective…”
Get more information

Differential activating and deactivating effects of natural ryanodine congeners on the calcium release channel of sarcoplasmic reticulum: evidence for separation of effects at functionally distinct sites by Humerickhouse, R A, Besch, Jr, H R, Gerzon, K, Ruest, L, Sutko, J L, Emmick, J T

“…Two novel natural ryanoids from extracts of the wood of Ryania speciosa Vahl were evaluated with sarcoplasmic reticulum (SR) vesicles for their binding…”
Get more information

Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5—sildenafil, tadalafil, and vardenafil by Dustan Sarazan, R., Crumb, William J., Beasley, Charles M., Emmick, Jeffrey T., Ferguson, Kenneth M., Strnat, Christine A., Sausen, Peter J.

“…Compounds that inhibit phosphodiesterase 5 (PDE5) have been developed for the treatment of erectile dysfunction. Because men with erectile dysfunction…”
Get full text

Aging and vasodilation to atrial peptides by Emmick, J T, Cohen, M L

“…Alterations in the levels or activity of atrial peptides may be associated with cardiovascular pathologies such as hypertension and congestive heart failure…”
Get more information

High affinity C10-Oeq ester derivatives of ryanodine. Activator-selective agonists of the sarcoplasmic reticulum calcium release channel by Humerickhouse, R A, Bidasee, K R, Gerzon, K, Emmick, J T, Kwon, S, Sutko, J L, Ruest, L, Besch, H R

“…The plant alkaloids ryanodine and dehydroryanodine are specific and potent modulators of the sarcoplasmic reticulum calcium release channel. In the present…”
Get full text

Effects of Tadalafil on Erectile Dysfunction in Men With Diabetes by SAENZ DE TEJADA, Inigo, ANGLIN, Greg, KNIGHT, James R, EMMICK, Jeffrey T

“…Effects of Tadalafil on Erectile Dysfunction in Men With Diabetes Iñigo Sáenz de Tejada , MD 1 , Greg Anglin , PHD 2 , James R. Knight , AB, MT (ASCP) SC 3 and…”
Get full text

Cardiovascular effects of tadalafil by Kloner, Robert A, Mitchell, Malcolm, Emmick, Jeffrey T

“…To determine the effects of tadalafil on the cardiovascular system, safety assessments were performed on a database of >4,000 subjects who received tadalafil…”
Get full text

Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men by Kloner, Robert A, Jackson, Graham, Emmick, Jeffrey T, Mitchell, Malcolm I, Bedding, Alun, Warner, Margaret R, Pereira, Alvaro

“…Tadalafil, a phosphodiesterase type 5 inhibitor, is effective therapy for erectile dysfunction (ED). Men with ED have a high incidence of comorbid conditions…”
Get more information

Time course of the interaction between tadalafil and nitrates by Kloner, Robert A, Hutter, Adolph M, Emmick, Jeffrey T, Mitchell, Malcolm I, Denne, Jonathan, Jackson, Graham

“…This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t1/2) of…”
Get full text

Overview of the cardiovascular effects of tadalafil by Emmick, J.T., Stuewe, S.R., Mitchell, M.

“…Because erectile dysfunction (ED) and cardiovascular disease share a number of risk factors, it is important to understand the haemodynamic and cardiovascular…”
Get full text

A Multicenter, Randomized, Double-Blind, Crossover Study to Evaluate Patient Preference between Tadalafil and Sildenafil by von Keitz, Alexander, Rajfer, Jacob, Segal, Scott, Murphy, Aileen, Denne, Jonathan, Costigan, Timothy, Lockhart, Daniel, Beasley, Charles M., Emmick, Jeffrey T.

“…Purpose: To assess patient preference for erectile dysfunction treatment between either sildenafil or tadalafil, each administered with their respective dosing…”
Get full text

The Combined Use of Ibutilide as an Active Control With Intensive Electrocardiographic Sampling and Signal Averaging as a Sensitive Method to Assess the Effects of Tadalafil on the Human QT Interval by Beasley, Charles M., Mitchell, Malcolm I., Dmitrienko, Alex A., Emmick, Jeffrey T., Shen, Wei, Costigan, Timothy M., Bedding, Alun W., Turik, Michael A., Bakhtyari, Arash, Warner, Margaret R., Ruskin, Jeremy N., Cantilena, Louis R., Kloner, Robert A.

“…This study was designed to evaluate effects of tadalafil, a phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction (ED), on the QT…”
Get full text

Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel by Gerzon, K, Humerickhouse, R A, Besch, Jr, H R, Bidasee, K R, Emmick, J T, Roeske, R W, Tian, Z, Ruest, L, Sutko, J L

“…Amino- and guanidinoacyl esters of ryanodine were prepared to evaluate the effect of basicity on the binding affinity of these derivatives for the sarcoplasmic…”
Get full text

Amino- and guanidinoacylryanodines : basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca2+-release channel by GERZON, K, HUMERICKHOUSE, R. A, BESCH, H. R, BIDASEE, K. R, EMMICK, J. T, ROESKE, R. W, ZHENPING TIAN, RUEST, L, SUTKO, J. L

Get full text

Amino- and guanidinoacylryanodines: Basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca super(2+)-release channel by Gerzon, K, Humerickhouse, R A, Besch, HR Jr, Bidasee, K R, Emmick, J T, Roeske, R W, Tian, Zhenping, Ruest, L, Sutko, J L

“…Amino- and guanidinoacyl esters of ryanodine were prepared to evaluate the effect of basicity on the binding affinity of these derivatives for the sarcoplasmic…”
Get full text

Time course of the interaction between tadalafil and nitrates by Kloner, R.A., Hutter, A.M., Emmick, J.T.

Get full text