Search Results - "Emmert‐Buck, Michael R"

Analysis of transcription factor mRNAs in identified oxytocin and vasopressin magnocellular neurons isolated by laser capture microdissection by Humerick, Madison, Hanson, Jeffrey, Rodriguez-Canales, Jaime, Lubelski, Daniel, Rashid, Omar M, Salinas, Yasmmyn D, Shi, Yijun, Ponzio, Todd, Fields, Raymond, Emmert-Buck, Michael R, Gainer, Harold

“…The oxytocin (Oxt) and vasopressin (Avp) magnocellular neurons (MCNs) in the hypothalamus are the only neuronal phenotypes that are present in the supraoptic…”
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Evaluation of ethanol-fixed, paraffin-embedded tissues for proteomic applications by Ahram, Mamoun, Flaig, Michael J., Gillespie, John W., Duray, Paul H., Linehan, W. Marston, Ornstein, David K., Niu, Shulan, Zhao, Yingming, Petricoin III, Emanuel F., Emmert-Buck, Michael R.

“…We previously reported that ethanol fixation and paraffin embedding of tissues produce excellent histomorphology and good preservation of macromolecules. Here,…”
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Mitochondrial proteome: Altered cytochrome c oxidase subunit levels in prostate cancer by Herrmann, Paul C., Gillespie, John W., Charboneau, Lu, Bichsel, Verena E., Paweletz, Cloud P., Calvert, Valerie S., Kohn, Elise C., Emmert-Buck, Michael R., Liotta, Lance A., Petricoin III, Emanuel F.

“…Laser capture microdissection was combined with reverse phase protein lysate arrays to quantitatively analyze the ratios of mitochondrial encoded cytochrome c…”
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Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma by Mukherjee, Sumana, Roth, Mark J, Dawsey, Sanford M, Yan, Wusheng, Rodriguez-Canales, Jaime, Erickson, Heidi S, Hu, Nan, Goldstein, Alisa M, Taylor, Philip R, Richardson, Annely M, Tangrea, Michael A, Chuaqui, Rodrigo F, Emmert-Buck, Michael R

“…Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect…”
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Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin’s lymphoma and primary mediastinal large B-cell lymphoma by EBERLE, Franziska C, RODRIGUEZ-CANALES, Jaime, MELTZER, Paul S, STAUDT, Louis M, EMMERT-BUCK, Michael R, JAFFE, Elaine S, LAI WEI, HANSON, Jeffrey C, KILLIAN, J. Keith, SUN, Hong-Wei, ADAMS, Lisa G, HEWITT, Stephen M, WILSON, Wyndham H, PITTALUGA, Stefania

“…Mediastinal gray zone lymphoma is a newly recognized entity with transitional morphological and immunophenotypic features between the nodular sclerosis subtype…”
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Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front by PAWELETZ, Cloud P, CHARBONEAU, Lu, BICHSEL, Verena E, SIMONE, Nicole L, CHEN, Tina, GILLESPIE, John W, EMMERT-BUCK, Michael R, ROTH, Mark J, PETRICOIN III, Emanuel F, LIOTTA, Lance A

“…Protein arrays are described for screening of molecular markers and pathway targets in patient matched human tissue during disease progression. In contrast to…”
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High-Throughput Microdissection for Next-Generation Sequencing by Rosenberg, Avi Z, Armani, Michael D, Fetsch, Patricia A, Xi, Liqiang, Pham, Tina Thu, Raffeld, Mark, Chen, Yun, O'Flaherty, Neil, Stussman, Rebecca, Blackler, Adele R, Du, Qiang, Hanson, Jeffrey C, Roth, Mark J, Filie, Armando C, Roh, Michael H, Emmert-Buck, Michael R, Hipp, Jason D, Tangrea, Michael A

“…Precision medicine promises to enhance patient treatment through the use of emerging molecular technologies, including genomics, transcriptomics, and…”
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Post-analysis follow-up and validation of microarray experiments by Chuaqui, Rodrigo F, Bonner, Robert F, Best, Carolyn J M, Gillespie, John W, Flaig, Michael J, Hewitt, Stephen M, Phillips, John L, Krizman, David B, Tangrea, Michael A, Ahram, Mamoun, Linehan, W Marston, Knezevic, Vladimir, Emmert-Buck, Michael R

“…Measurement of gene-expression profiles using microarray technology is becoming increasingly popular among the biomedical research community. Although there…”
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Gene Promoter Methylation in Prostate Tumor–Associated Stromal Cells by Hanson, Jeffrey A., Gillespie, John W., Grover, Amelia, Tangrea, Michael A., Chuaqui, Rodrigo F., Emmert-Buck, Michael R., Tangrea, Joseph A., Libutti, Stephen K., Linehan, W. Marston, Woodson, Karen G.

“…Background: Gene expression can be silenced through the methylation of specific sites in the promoter region. This mechanism of gene silencing has an important…”
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2D Differential In-gel Electrophoresis for the Identification of Esophageal Scans Cell Cancer-specific Protein Markers by Zhou, Ge, Li, Hongmei, DeCamp, Dianne, Chen, She, Shu, Hongjun, Gong, Yi, Flaig, Michael, Gillespie, John W, Hu, Nan, Taylor, Philip R, Emmert-Buck, Michael R, Liotta, Lance A, Petricoin, 3rd, Emanuel F, Zhao, Yingming

“…The reproducibility of conventional two-dimensional (2D) gel electrophoresis can be improved using differential in-gel electrophoresis (DIGE), a new emerging…”
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An NIH intramural percubator as a model of academic-industry partnerships: from the beginning of life through the valley of death by Emmert-Buck, Michael R

“…In 2009 the NIH publicly announced five strategic goals for the institutes that included the critical need to translate research discoveries into public…”
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Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detection by Xiao, Yan, Gao, Xiugong, Gannot, Gallya, Emmert‐Buck, Michael R, Srivastava, Sudhir, Wagner, Paul D., Amos, Michael D., Barker, Peter E.

“…In an effort to improve affinity biomarker validation in fixed patient tissue specimens, we have developed a novel quantum dot‐based bioimaging system that…”
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Proteomic profiling of cancer--opportunities, challenges, and context by Arnott, David, Emmert-Buck, Michael R

“…The article by Roesch-Ely and colleagues in a recent issue of The Journal of Pathology describes the use of proteomic techniques to examine mucosal biopsies in…”
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Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1 by Chandrasekharappa, Settara C., Guru, Siradanahalli C., Manickam, Pachiappan, Olufemi, Shodimu-Emmanuel, Collins, Francis S., Emmert-Buck, Michael R., Debelenko, Larisa V., Zhuang, Zhengping, Lubensky, Irina A., Liotta, Lance A., Crabtree, Judy S., Wang, Yingping, Roe, Bruce A., Weisemann, Jane, Boguski, Mark S., Agarwal, Sunita K., Kester, Mary Beth, Kim, Young S., Heppner, Christina, Dong, Qihan, Spiegel, Allen M., Burns, A. Lee, Marx, Stephen J.

“…Multiple endocrine neoplasia-type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors in parathyroids, enteropancreatic…”
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Why is it crucial to reintegrate pathology into cancer research by Rodriguez-Canales, Jaime, Eberle, Franziska C, Jaffe, Elaine S, Emmert-Buck, Michael R

“…The integration of pathology with molecular biology is vital if we are to enhance the translational value of cancer research. Pathology represents a bridge…”
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Laser Capture Microdissection by Emmert-Buck, Michael R., Bonner, Robert F., Smith, Paul D., Chuaqui, Rodrigo F., Zhuang, Zhengping, Goldstein, Seth R., Weiss, Rhonda A., Liotta, Lance A.

“…Laser capture microdissection (LCM) under direct microscopic visualization permits rapid one-step procurement of selected human cell populations from a section…”
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Layered electrophoretic transfer - A method for pre-analytic processing of histological sections by Zhu, Liang, Tangrea, Michael A, Mukherjee, Sumana, Emmert-Buck, Michael R

“…Current technologies for measuring protein expression across a tissue section are based on MS or in situ detection such as immunohistochemistry. However, due…”
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Increased expression of VEGF121/VEGF165–189 ratio results in a significant enhancement of human prostate tumor angiogenesis by Catena, Raul, Muniz‐Medina, Vanessa, Moralejo, Beatriz, Javierre, Biola, Best, Carolyn J.M., Emmert‐Buck, Michael R., Green, Jeffrey E., Baker, Carl C., Calvo, Alfonso

“…Vascular endothelial growth factor (VEGF) is a proangiogenic factor upregulated in many tumors. The alternative splicing of VEGF mRNA renders 3 major isoforms…”
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High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population by Hu, Nan, Wang, Chaoyu, Su, Hua, Li, Wen-Jun, Emmert-Buck, Michael R., Li, Guang, Roth, Mark J., Tang, Ze-Zhong, Lu, Ning, Giffen, Carol, Albert, Paul S., Taylor, Philip R., Goldstein, Alisa M.

“…Because previous studies have shown that loss of heterozygosity (LOH) is common on chromosome arm 9p in esophageal squamous cell carcinoma (ESCC) and that…”
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Laser-capture microdissection: opening the microscopic frontier to molecular analysis by Simone, Nicole L, Bonner, Robert F, Gillespie, John W, Emmert-Buck, Michael R, Liotta, Lance A

“…As the list of expressed human genes expands, a major scientific challenge is to understand the molecular events that drive normal tissue morphogenesis and the…”
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