Validation of a Modified 28-Day Rat Study to Evidence Effects of Test Compounds on the Immune System

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Bibliographic Details
Published in:	Regulatory toxicology and pharmacology Vol. 22; no. 1; pp. 54 - 56
Main Authors:	Richterreichhelm, H.B., Dasenbrock, C.A., Descotes, G., Emmendorffer, A.C., Ernst, H.U., Harleman, J.H., Hildebrand, B., Kuttler, K., Ruhlfehlert, C.I., Schilling, K., Schulte, A.E., Vohr, H.W.
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01-08-1995 Elsevier
Subjects:	Animals Biological and medical sciences Cyclosporine - toxicity Female General aspects. Methods Hemolytic Plaque Technique Humans Immune System - drug effects Immune System - pathology Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - drug effects Immunoglobulin M - biosynthesis Immunoglobulin M - blood Immunoglobulin M - drug effects Immunophenotyping Kidney - drug effects Kidney - pathology Killer Cells, Natural - immunology Liver - drug effects Liver - pathology Lymphocyte Activation - drug effects Lymphoid Tissue - drug effects Lymphoid Tissue - pathology Macrophage Activation - drug effects Male Medical sciences Mitogens - pharmacology Rats Rats, Wistar Toxicity Tests - standards Toxicology Immunopathology Evaluation Rat Toxicity Chemical compound Multicenter study Rodentia Oral administration Risk Vertebrata Mammalia Investigation method Animal
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ISSN:	0273-2300 1096-0295
DOI:	10.1006/rtph.1995.1068