Search Results - "Emmanuel J. H. J. Wiertz"

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections by van Diemen, Ferdy R, Kruse, Elisabeth M, Hooykaas, Marjolein J G, Bruggeling, Carlijn E, Schürch, Anita C, van Ham, Petra M, Imhof, Saskia M, Nijhuis, Monique, Wiertz, Emmanuel J H J, Lebbink, Robert Jan

“…Herpesviruses infect the majority of the human population and can cause significant morbidity and mortality. Herpes simplex virus (HSV) type 1 causes cold…”
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Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2 by Cremer, Tom, Hoelen, Hanneke, van de Weijer, Michael L, Janssen, George M, Costa, Ana I, van Veelen, Peter A, Lebbink, Robert Jan, Wiertz, Emmanuel J H J

“…Type 1 diabetes (T1D) is characterized by HLA class I-mediated presentation of autoantigens on the surface of pancreatic β-cells. Recognition of these…”
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EBV MicroRNA BART16 Suppresses Type I IFN Signaling by Hooykaas, Marjolein J G, van Gent, Michiel, Soppe, Jasper A, Kruse, Elisabeth, Boer, Ingrid G J, van Leenen, Dik, Groot Koerkamp, Marian J A, Holstege, Frank C P, Ressing, Maaike E, Wiertz, Emmanuel J H J, Lebbink, Robert Jan

“…Type I IFNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activities and shaping the adaptive immune response…”
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The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation by Zuo, Jianmin, Currin, Andrew, Griffin, Bryan D, Shannon-Lowe, Claire, Thomas, Wendy A, Ressing, Maaike E, Wiertz, Emmanuel J H J, Rowe, Martin

“…Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence…”
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The DNase of Gammaherpesviruses Impairs Recognition by Virus-Specific CD8+ T Cells through an Additional Host Shutoff Function by JIANMIN ZUO, THOMAS, Wendy, VAN LEEUWEN, Daphne, MIDDELDORP, Jaap M, WIERTZ, Emmanuel J. H. J, RESSING, Maaike E, ROWE, Martin

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TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I by Harriff, Melanie J, Burgdorf, Sven, Kurts, Christian, Wiertz, Emmanuel J H J, Lewinsohn, Deborah A, Lewinsohn, David M

“…Processing and presentation of antigen on MHC-I class I molecules serves to present peptides derived from cytosolic proteins to CD8(+) T cells. Infection with…”
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The “Bridge” in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection by HORST, Daniëlle, BURMEISTER, Wim P, BOER, Ingrid G. J, LEEUWEN, Daphne Van, BUISSON, Marlyse, GORBALENYA, Alexander E, WIERTZ, Emmanuel J. H. J, RESSING, Maaike E

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Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97 by Hoelen, Hanneke, Zaldumbide, Arnaud, van Leeuwen, Wouter F, Torfs, Ellen C W, Engelse, Marten A, Hassan, Chopie, Lebbink, Robert Jan, de Koning, Eelco J, Resssing, Maaike E, de Ru, Arnoud H, van Veelen, Peter A, Hoeben, Rob C, Roep, Bart O, Wiertz, Emmanuel J H J

“…Patients with type 1 diabetes (T1D) suffer from beta-cell destruction by CD8+ T-cells that have preproinsulin as an important target autoantigen. It is of…”
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Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines by Hooykaas, Marjolein J G, Kruse, Elisabeth, Wiertz, Emmanuel J H J, Lebbink, Robert Jan

“…Epstein-Barr virus (EBV) establishes lifelong infections in its human host. The virus is associated with a broad range of malignancies of lymphoid and…”
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A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape by Lebbink, Robert Jan, de Jong, Dorien C. M., Wolters, Femke, Kruse, Elisabeth M., van Ham, Petra M., Wiertz, Emmanuel J. H. J., Nijhuis, Monique

“…HIV presents one of the highest evolutionary rates ever detected and combination antiretroviral therapy is needed to overcome the plasticity of the virus…”
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Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle by Croft, Nathan P, Shannon-Lowe, Claire, Bell, Andrew I, Horst, Daniëlle, Kremmer, Elisabeth, Ressing, Maaike E, Wiertz, Emmanuel J H J, Middeldorp, Jaap M, Rowe, Martin, Rickinson, Alan B, Hislop, Andrew D

“…The gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic…”
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A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope by Luteijn, Rutger D, Praest, Patrique, Thiele, Frank, Sadasivam, Saravanan Manikam, Singethan, Katrin, Drijfhout, Jan W, Bach, Christian, de Boer, Steffen Matthijn, Lebbink, Robert J, Tao, Sha, Helfer, Markus, Bach, Nina C, Protzer, Ulrike, Costa, Ana I, Killian, J Antoinette, Drexler, Ingo, Wiertz, Emmanuel J H J

“…The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds…”
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The Capacity of UL49.5 Proteins To Inhibit TAP Is Widely Distributed among Members of the Genus Varicellovirus by VERWEIJ, Marieke C, LIPINSKA, Andrea D, WIERTZ, Emmanuel J. H. J, KOPPERS-LALIC, Danijela, VAN LEEUWEN, Wouter F, COHEN, Jeffrey I, KINCHINGTON, Paul R, MESSAOUDI, Ilhem, BIENKOWSKA-SZEWCZYK, Krystyna, RESSING, Maaike E, RIJSEWIJK, Frans A. M

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Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors by Zaldumbide, Arnaud, Carlotti, Françoise, Gonçalves, Manuel A, Knaän-Shanzer, Shoshan, Cramer, Steve J, Roep, Bart O, Wiertz, Emmanuel J H J, Hoeben, Rob C

“…Viral gene carriers are being widely used as gene transfer systems in (trans)differentiation and reprogramming strategies. Forced expression of key regulators…”
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Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants by de la Garza-Rodea, Anabel S, Verweij, Marieke C, Boersma, Hester, van der Velde-van Dijke, Ietje, de Vries, Antoine A F, Hoeben, Rob C, van Bekkum, Dirk W, Wiertz, Emmanuel J H J, Knaän-Shanzer, Shoshan

“…Mesenchymal stem cells (MSCs) are multipotent cells residing in the connective tissue of many organs and holding great potential for tissue repair. In culture,…”
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Epstein-Barr Virus Isolates Retain Their Capacity To Evade T Cell Immunity through BNLF2a despite Extensive Sequence Variation by HORST, Daniëlle, BURROWS, Scott R, GATHERER, Derek, VAN WILGENBURG, Bonnie, BELL, Melissa J, BOER, Ingrid G. J, RESSING, Maaike E, WIERTZ, Emmanuel J. H. J

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Herpesviruses and immunity: The art of evasion by Griffin, Bryan D., Verweij, Marieke C., Wiertz, Emmanuel J.H.J.

“…Herpesviruses have evolved several effective strategies to counter the host immune response. Chief among these is inhibition of the host MHC class I antigen…”
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Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation by van de Weijer, Michael L, Schuren, Anouk B C, van den Boomen, Dick J H, Mulder, Arend, Claas, Frans H J, Lehner, Paul J, Lebbink, Robert Jan, Wiertz, Emmanuel J H J

“…Misfolded endoplasmic reticulum (ER) proteins are dislocated towards the cytosol and degraded by the ubiquitin-proteasome system in a process called…”
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The Comparative Genomics of Human Respiratory Syncytial Virus Subgroups A and B: Genetic Variability and Molecular Evolutionary Dynamics by Tan, Lydia, Coenjaerts, Frank E J, Houspie, Lieselot, Viveen, Marco C, van Bleek, Grada M, Wiertz, Emmanuel J H J, Martin, Darren P, Lemey, Philippe

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Bovine Herpesvirus 1 UL49.5 Protein Inhibits the Transporter Associated with Antigen Processing despite Complex Formation with Glycoprotein M by LIPINSKA, Andrea D, KOPPERS-LALIC, Danijela, RYCHLOWSKI, Michal, ADMIRAAL, Pieter, RIJSEWIJK, Frans A. M, BIENKOWSKA-SZEWCZYK, Krystyna, WIERTZ, Emmanuel J. H. J

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