Search Results - "Emmanuel, Michel J"

Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors by Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

“…The specificity of the immune response relies on processing of foreign proteins and presentation of antigenic peptides at the cell surface. Inhibition of…”
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Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors by Bekkali, Younes, Thomson, David S., Betageri, Raj, Emmanuel, Michel J., Hao, Ming-Hong, Hickey, Eugene, Liu, Weimin, Patel, Usha, Ward, Yancey D., Young, Erick R.R., Nelson, Richard, Kukulka, Alison, Brown, Maryanne L., Crane, Kathy, White, Della, Freeman, Dorothy M., Labadia, Mark E., Wildeson, Jessi, Spero, Denice M.

“…The synthesis and SAR of the first succinyl-nitrile-based compounds as Cathepsin S inhibitors are described. The synthesis and in vitro activities of a series…”
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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors by Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Girardot, Marc, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

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Rapid, sensitive and efficient HPLC assays for HIV-1 proteinase by Betageri, R, Hopkins, J L, Thibeault, D, Emmanuel, M J, Chow, G C, Skoog, M T, de Dreu, P, Cohen, K A

“…The proteinase encoded by human immunodeficiency virus type 1 (HIV-1) cleaves peptide substrates of sequences derived from processing sites in HIV-1 gag-pol…”
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Rhinovirus 3C protease catalyzes efficient cleavage of a fluorescein-labeled peptide affording a rapid and robust assay by Hopkins, J L, Betageri, R, Cohen, K A, Emmanuel, M J, Joseph, C R, Bax, P M, Pallai, P V, Skoog, M T

“…The 3C protease encoded by human rhinovirus type 2 catalyzes with equal efficiency cleavage of a peptide substrate with or without a fluorescein label attached…”
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