Search Results - "Emma C. Wall"

A retrospective analysis of 20,178 adult neurological infection admissions to United Kingdom critical care units from 2001 to 2020 by Donovan, Joseph, Glover, Abena, Gregson, John, Hitchings, Andrew W, Wall, Emma C, Heyderman, Robert S

“…Neurological infection is an important cause of critical illness, yet little is known on the epidemiology of neurological infections requiring critical care…”
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STIMULATE-ICP: A pragmatic, multi-centre, cluster randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID: A structured protocol by Forshaw, Denise, Wall, Emma C, Prescott, Gordon, Dehbi, Hakim-Moulay, Green, Angela, Attree, Emily, Hismeh, Lyth, Strain, William D, Crooks, Michael G, Watkins, Caroline, Robson, Chris, Banerjee, Rajarshi, Lorgelly, Paula, Heightman, Melissa, Banerjee, Amitava

“…Long COVID (LC), the persistent symptoms ≥12 weeks following acute COVID-19, presents major threats to individual and public health across countries, affecting…”
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COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history by Townsley, Hermaleigh, Gahir, Joshua, Russell, Timothy W, Greenwood, David, Carr, Edward J, Dyke, Matala, Adams, Lorin, Miah, Murad, Clayton, Bobbi, Smith, Callie, Miranda, Mauro, Mears, Harriet V, Bailey, Chris, Black, James R M, Fowler, Ashley S, Crawford, Margaret, Wilkinson, Katalin, Hutchinson, Matthew, Harvey, Ruth, O'Reilly, Nicola, Kelly, Gavin, Goldstone, Robert, Beale, Rupert, Papineni, Padmasayee, Corrah, Tumena, Gilson, Richard, Caidan, Simon, Nicod, Jerome, Gamblin, Steve, Kassiotis, George, Libri, Vincenzo, Williams, Bryan, Gandhi, Sonia, Kucharski, Adam J, Swanton, Charles, Bauer, David L V, Wall, Emma C

“…SARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought to characterise…”
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Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants by Russell, Timothy W, Townsley, Hermaleigh, Abbott, Sam, Hellewell, Joel, Carr, Edward J, Chapman, Lloyd A C, Pung, Rachael, Quilty, Billy J, Hodgson, David, Fowler, Ashley S, Adams, Lorin, Bailey, Chris, Mears, Harriet V, Harvey, Ruth, Clayton, Bobbi, O'Reilly, Nicola, Ngai, Yenting, Nicod, Jerome, Gamblin, Steve, Williams, Bryan, Gandhi, Sonia, Swanton, Charles, Beale, Rupert, Bauer, David L V, Wall, Emma C, Kucharski, Adam J

“…The emergence of successive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) during 2020 to 2022, each exhibiting…”
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Bacterial Meningitis in Malawian Adults, Adolescents, and Children During the Era of Antiretroviral Scale-up and Haemophilus influenzae Type b Vaccination, 2000–2012 by Wall, Emma C., Everett, Dean B., Mukaka, Mavuto, Bar-Zeev, Naor, Feasey, Nicholas, Jahn, Andreas, Moore, Mike, van Oosterhout, Joep J., Pensalo, Paul, Baguimira, Kenneth, Gordon, Stephen B., Molyneux, Elizabeth M., Carrol, Enitan D., French, Neil, Molyneux, Malcolm E., Heyderman, Robert S.

“…Culture positive bacterial meningitis has fallen over a 12-year period in urban Malawi following Hib vaccination. Hib, NTS, and pneumococcal meningitis have…”
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Goal directed therapy for suspected acute bacterial meningitis in adults and adolescents in sub-Saharan Africa by Wall, Emma C, Mukaka, Mavuto, Denis, Brigitte, Mlozowa, Veronica S, Msukwa, Malango, Kasambala, Khumbo, Nyrienda, Mulinda, Allain, Theresa J, Faragher, Brian, Heyderman, Robert S, Lalloo, David G

“…Mortality from acute bacterial meningitis (ABM) in sub-Saharan African adults and adolescents exceeds 50%. We tested if Goal Directed Therapy (GDT) was…”
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High mortality amongst adolescents and adults with bacterial meningitis in sub-Saharan Africa: an analysis of 715 cases from Malawi by Wall, Emma C, Cartwright, Katharine, Scarborough, Matthew, Ajdukiewicz, Katherine M, Goodson, Patrick, Mwambene, James, Zijlstra, Eduard E, Gordon, Stephen B, French, Neil, Faragher, Brian, Heyderman, Robert S, Lalloo, David G

“…Mortality from bacterial meningitis in African adults is significantly higher than those in better resourced settings and adjunctive therapeutic interventions…”
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Community-acquired bacterial meningitis by van de Beek, Diederik, Brouwer, Matthijs C, Koedel, Uwe, Wall, Emma C

“…Progress has been made in the prevention and treatment of community-acquired bacterial meningitis during the past three decades but the burden of the disease…”
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CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis by Wall, Emma C, Brownridge, Philip, Laing, Gavin, Terra, Vanessa S, Mlozowa, Veronica, Denis, Brigitte, Nyirenda, Mulinda, Allain, Theresa, Ramos-Sevillano, Elisa, Carrol, Enitan, Collins, Andrea, Gordon, Stephen B, Lalloo, David G, Wren, Brendan, Beynon, Robert, Heyderman, Robert S, Brown, Jeremy S

“…Mortality from bacterial meningitis, predominately caused by , exceeds 50% in sub-Saharan African countries with high HIV prevalence. Underlying causes of high…”
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Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination by Wall, Emma C, Wu, Mary, Harvey, Ruth, Kelly, Gavin, Warchal, Scott, Sawyer, Chelsea, Daniels, Rodney, Hobson, Philip, Hatipoglu, Emine, Ngai, Yenting, Hussain, Saira, Nicod, Jerome, Goldstone, Robert, Ambrose, Karen, Hindmarsh, Steve, Beale, Rupert, Riddell, Andrew, Gamblin, Steve, Howell, Michael, Kassiotis, George, Libri, Vincenzo, Williams, Bryan, Swanton, Charles, Gandhi, Sonia, Bauer, David LV

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Osmotic therapies added to antibiotics for acute bacterial meningitis by Wall, Emma C B, Ajdukiewicz, Katherine M B, Heyderman, Robert S, Garner, Paul

“…Every day children and adults throughout the world die from acute community-acquired bacterial meningitis, particularly in low-income countries. Survivors are…”
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Haemophilus influenzae is fighting back: is serotype a an emerging threat? by Wall, Emma C, Taha, Muhamed-Keir

“…Haemophilus influenzae serotype b (Hib) was once the leading cause of bacterial meningitis in children, causing more than 300 000 deaths per year in 2000.1 The…”
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Acute bacterial meningitis by Wall, Emma C., Chan, Jia Mun, Gil, Eliza, Heyderman, Robert S.

“…Community-acquired bacterial meningitis is a continually changing disease. This review summarises both dynamic epidemiology and emerging data on pathogenesis…”
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AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC by Wall, Emma C, Wu, Mary, Harvey, Ruth, Kelly, Gavin, Warchal, Scott, Sawyer, Chelsea, Daniels, Rodney, Adams, Lorin, Hobson, Philip, Hatipoglu, Emine, Ngai, Yenting, Hussain, Saira, Ambrose, Karen, Hindmarsh, Steve, Beale, Rupert, Riddell, Andrew, Gamblin, Steve, Howell, Michael, Kassiotis, George, Libri, Vincenzo, Williams, Bryan, Swanton, Charles, Gandhi, Sonia, Bauer, David LV

“…Two doses of AZD1222 generated NAb activity against the Wildtype strain bearing a spike identical to that encoded by the vaccine in all participants (median…”
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Three-dose vaccination elicits neutralising antibodies against omicron by Wu, Mary, Wall, Emma C, Carr, Edward J, Harvey, Ruth, Townsley, Hermaleigh, Mears, Harriet V, Adams, Lorin, Kjaer, Svend, Kelly, Gavin, Warchal, Scott, Sawyer, Chelsea, Kavanagh, Caitlin, Queval, Christophe J, Ngai, Yenting, Hatipoglu, Emine, Ambrose, Karen, Hindmarsh, Steve, Beale, Rupert, Gamblin, Steve, Howell, Michael, Kassiotis, George, Libri, Vincenzo, Williams, Bryan, Gandhi, Sonia, Swanton, Charles, Bauer, David LV

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Steroid use in non-pneumococcal and non-Haemophilus bacterial meningitis – Authors' reply by van de Beek, Diederik, Brouwer, Matthijs C, Koedel, Uwe, Wall, Emma C

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Gnathostomiasis acquired by British tourists in Botswana by Herman, Joanna S, Wall, Emma C, van-Tulleken, Christoffer, Godfrey-Faussett, Peter, Bailey, Robin L, Chiodini, Peter L

“…Infection with Gnathostoma spinigerum has been generally confined to Southeast Asia and Central and South America. However, gnathostomiasis was recently found…”
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WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed by Wu, Mary Y, Carr, Edward J, Harvey, Ruth, Mears, Harriet V, Kjaer, Svend, Townsley, Hermaleigh, Hobbs, Agnieszka, Ragno, Martina, Herman, Lou S, Adams, Lorin, Gamblin, Steve, Howell, Michael, Beale, Rupert, Brown, Michael, Williams, Bryan, Gandhi, Sonia, Swanton, Charles, Wall, Emma C, Bauer, David L V

“…[...]in the absence of real-world efficacy data, consideration of the EC50 value relative to pharmacokinetic data (eg, measured serum concentrations of mAbs…”
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Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer by Fendler, Annika, Shepherd, Scott T C, Au, Lewis, Wu, Mary, Harvey, Ruth, Schmitt, Andreas M, Tippu, Zayd, Shum, Benjamin, Farag, Sheima, Rogiers, Aljosja, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Deng, Daqi, Kjaer, Svend, Song, Ok-Ryul, Queval, Christophe, Kavanagh, Caitlin, Wall, Emma C, Carr, Edward J, Caidan, Simon, Gavrielides, Mike, MacRae, James I, Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O'Flaherty, Molly, Shea, Robyn L, Gardner, Gail, Murray, Darren, Yousaf, Nadia, Jhanji, Shaman, Tatham, Kate, Cunningham, David, Van As, Nicholas, Young, Kate, Furness, Andrew J S, Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L V, Kassiotis, George, Howell, Michael, Nicholson, Emma, Walker, Susanna, Larkin, James, Turajlic, Samra

“…[...]we evaluated omicron nAbT in four patients with a history of breakthrough delta infection after two vaccine doses. The exact correlates of immune…”
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Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer by Fendler, Annika, Shepherd, Scott T.C., Au, Lewis, Wilkinson, Katalin A., Wu, Mary, Schmitt, Andreas M., Tippu, Zayd, Farag, Sheima, Rogiers, Aljosja, Harvey, Ruth, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Shum, Benjamin, Gerard, Camille L., Deng, Daqi, Kjaer, Svend, Song, Ok-Ryul, Queval, Christophe, Kavanagh, Caitlin, Wall, Emma C., Carr, Edward J., Namjou, Sina, Caidan, Simon, Gavrielides, Mike, MacRae, James I., Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O’Flaherty, Molly, Shea, Robyn L., Gardner, Gail, Murray, Darren, Popat, Sanjay, Yousaf, Nadia, Jhanji, Shaman, Van As, Nicholas, Young, Kate, Furness, Andrew J.S., Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L.V., Kassiotis, George, Howell, Michael, Nicholson, Emma, Walker, Susanna, Wilkinson, Robert J., Larkin, James, Turajlic, Samra

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