Bing-Neel syndrome: A case reports

Bing-Neel syndrome: A case reports

Introduction Bing-Neel syndrome (BNS) is a rare complication of of Waldenström macroglobulinemia (WM) identified by involvement of central nervous system (CNS) lymphoplasmacytic cells. Case report We present a patient who was diagnosed with Bing-Neel syndrome four years after the diagnosis of Walden...

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Bibliographic Details
Published in:Journal of oncology pharmacy practice Vol. 27; no. 7; pp. 1758 - 1761
Main Authors: Demircioğlu, Sinan, Oltulu, Pembe, Emlik, Ganime D, Tekinalp, Atakan, Çeneli, Özcan
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01-10-2021
Sage Publications Ltd
Subjects:
Biopsy
Brain Diseases
Case reports
Central nervous system
Cytarabine
Diagnosis
Enzyme inhibitors
Fludarabine
Humans
Inhibitor drugs
Macroglobulinemia
Methotrexate
Neuroimaging
Patients
Protein-tyrosine kinase
Pyrazoles
Pyrimidines
Syndrome
Targeted cancer therapy
Waldenstrom Macroglobulinemia - diagnosis
Waldenstrom Macroglobulinemia - drug therapy
ibrutinib
Waldenström macroglobulinemia
Bing-Neel syndrome
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Summary:Introduction Bing-Neel syndrome (BNS) is a rare complication of of Waldenström macroglobulinemia (WM) identified by involvement of central nervous system (CNS) lymphoplasmacytic cells. Case report We present a patient who was diagnosed with Bing-Neel syndrome four years after the diagnosis of Waldenström macroglobulinemia. Management & outcome The patient was admitted with neurological symptoms. There were lesions associated with WM involvement on brain imaging. The diagnosis was made by brain biopsy. High dose methotrexate treatment was given. Discussion CNS infiltrating agents such as fludarabine, methotrexate and cytarabine are often used in BNS treatment. Ibrutinib, which is a new bruton tyrosine kinase inhibitor, has recently started to be used in BNS treatment, as it has been shown to be effective and penetrate the CNS.
Bibliography:ObjectType-Case Study-2
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ISSN:1078-1552
1477-092X
DOI:10.1177/1078155220983426