Search Results - "Emily Parker"

Economic Costs of Diabetes in the U.S. in 2022 by Parker, Emily D, Lin, Janice, Mahoney, Troy, Ume, Nwanneamaka, Yang, Grace, Gabbay, Robert A, ElSayed, Nuha A, Bannuru, Raveendhara R

“…This study updates previous estimates of the economic burden of diagnosed diabetes, with calculation of the health resource use and indirect costs attributable…”
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Reciprocal allostery arising from a bienzyme assembly controls aromatic amino acid biosynthesis in Prevotella nigrescens by Bai, Yu, Parker, Emily J.

“…Modular protein assembly has been widely reported as a mechanism for constructing allosteric machinery. Recently, a distinctive allosteric system has been…”
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Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase by Scully, Thomas W, Jiao, Wanting, Mittelstädt, Gerd, Parker, Emily J

“…Anthranilate phosphoribosyltransferase catalyses the second reaction in the biosynthesis of tryptophan from chorismate in microorganisms and plants. The enzyme…”
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On the Temperature Dependence of Enzyme-Catalyzed Rates by Arcus, Vickery L, Prentice, Erica J, Hobbs, Joanne K, Mulholland, Adrian J, Van der Kamp, Marc W, Pudney, Christopher R, Parker, Emily J, Schipper, Louis A

“…One of the critical variables that determine the rate of any reaction is temperature. For biological systems, the effects of temperature are convoluted with…”
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Editorial overview: ‘The amazing power of physics to provide chemical insight into catalysis and regulation’ … something better by Parker, Emily J., Schofield, Christopher J.

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Emerging Patterns of Foot and Ankle Injuries in Pickleball Players: A Short Report by Kingston, Kiera, Parker, Emily B., Higgins, Alexander, Smith, Jeremy T.

“…Background: Pickleball’s surging popularity has driven an increase in injuries presenting to medical providers. This study seeks to describe the epidemiology…”
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Conformational interdomain flexibility in a bacterial α-isopropylmalate synthase is necessary for leucine biosynthesis by Bai, Yu, Jiao, Wanting, Vörster, Jan, Parker, Emily J.

“…α-Isopropylmalate synthase (IPMS) catalyzes the first step in leucine (Leu) biosynthesis and is allosterically regulated by the pathway end product, Leu. IPMS…”
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Precise Positioning of Water Is Critical for Hydrolysis Catalyzed by 5′-Methylthioadenosine Nucleosidase by Jiao, Wanting, Mittelstädt, Gerd, Parker, Emily J.

“…Enzyme-catalyzed hydrolysis is a fundamental chemical transformation involved in many essential metabolic processes. The enzyme…”
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A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis by Jiao, Wanting, Fan, Yifei, Blackmore, Nicola J., Parker, Emily J.

“…Allostery exploits the conformational dynamics of enzymes by triggering a shift in population ensembles toward functionally distinct conformational or dynamic…”
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Cortical Thinning, Functional Connectivity, and Mood-Related Impulsivity in Schizophrenia: Relationship to Aggressive Attitudes and Behavior by Hoptman, Matthew J., Antonius, Daniel, Mauro, Cristina J., Parker, Emily M., Javitt, Daniel C.

“…A robust association was found in patients with schizophrenia between cortical thinning in ventral prefrontal regions and increased impulsivity, which likely…”
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American Orthopaedic Foot and Ankle Society Annual Meeting All-in-person Attendance Results in Immense Carbon Expenditure by Parker, Emily B., Bluman, Adair, Pruneski, James, Soens, William, Bernstein, Aaron, Smith, Jeremy T., Bluman, Eric M.

“…Professional society conferences are integral to the medical profession. However, airline travel is a major contributor to greenhouse gas production, and the…”
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“It's kinda like a sick joke”: Young people, labor market experiences, and the COVID‐19 pandemic by Shupp Parker, Emily, Kloc, Michael, Friedline, Terri, Shanks, Trina

“…Abstract Young people struggle to enter a new capitalist economy characterized by job instability and devalued wages and labor. The COVID‐19 pandemic…”
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Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis by Jiao, Wanting, Blackmore, Nicola J, Nazmi, Ali Reza, Parker, Emily J

“…The first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS), adopts a range of distinct allosteric regulation…”
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Burden of Illness Associated with Tenosynovial Giant Cell Tumors by Burton, Tanya M., Ye, Xin, Parker, Emily D., Bancroft, Tim, Healey, John

“…Little is known about the burden of illness in patients with tenosynovial giant cell tumors (TGCT), which are rare, typically benign, lesions of the synovial…”
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Reply to the Letter to the Editor: American Orthopaedic Foot and Ankle Society Annual Meeting All-in-person Attendance Results in Immense Carbon Expenditure by Bluman, Adair H, Parker, Emily B, Smith, Jeremy T, Bluman, Eric M

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Change in Heat Capacity for Enzyme Catalysis Determines Temperature Dependence of Enzyme Catalyzed Rates by Hobbs, Joanne K, Jiao, Wanting, Easter, Ashley D, Parker, Emily J, Schipper, Louis A, Arcus, Vickery L

“…The increase in enzymatic rates with temperature up to an optimum temperature (T opt) is widely attributed to classical Arrhenius behavior, with the decrease…”
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Change in Weight Status and Development of Hypertension by Parker, Emily D, Sinaiko, Alan R, Kharbanda, Elyse O, Margolis, Karen L, Daley, Matt F, Trower, Nicole K, Sherwood, Nancy E, Greenspan, Louise C, Lo, Joan C, Magid, David J, O'Connor, Patrick J

“…To examine the association of BMI percentile and change in BMI percentile to change in blood pressure (BP) percentile and development of hypertension (HTN)…”
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Aminoacylation of Indole Diterpenes by Cluster-Specific Monomodular NRPS-like Enzymes by McLellan, Rose M, Cameron, Rosannah C, Nicholson, Matthew J, Parker, Emily J

“…Decoration of the core scaffolds of indole diterpene (IDT) natural products is key to generating structural and bioactivity diversity. Aminoacylation as a…”
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The Molecular Basis for the Substrate Specificity of Protein Tyrosine Phosphatase PTPN3 by Parker, Emily J.

“…In this issue of Structure, Chen et al. present structures of the FERM-containing protein tyrosine phosphatase PTPN3 in complex with a phosphopeptide fragment…”
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Exploring modular allostery via interchangeable regulatory domains by Fan, Yifei, Cross, Penelope J., Jameson, Geoffrey B., Parker, Emily J.

“…Most proteins comprise two or more domains from a limited suite of protein families. These domains are often rearranged in various combinations through gene…”
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