Search Results - "Emily J. Onufer"

Enterically derived high-density lipoprotein restrains liver injury through the portal vein by Han, Yong-Hyun, Onufer, Emily J, Huang, Li-Hao, Sprung, Robert W, Davidson, W Sean, Czepielewski, Rafael S, Wohltmann, Mary, Sorci-Thomas, Mary G, Warner, Brad W, Randolph, Gwendalyn J

“…The biogenesis of high-density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most of the HDL in the…”
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A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages by Buechler, Matthew B., Kim, Ki-Wook, Onufer, Emily J., Williams, Jesse W., Little, Christine C., Dominguez, Claudia X., Li, Qingling, Sandoval, Wendy, Cooper, Jonathan E., Harris, Charles A., Junttila, Melissa R., Randolph, Gwendalyn J., Turley, Shannon J.

“…Tissue-resident macrophages require specific milieus for the maintenance of defining gene-expression programs. Expression of the transcription factor GATA6 is…”
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LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth by Zhang, Nan, Kim, Seung Hyeon, Gainullina, Anastasiia, Erlich, Emma C, Onufer, Emily J, Kim, Jiseon, Czepielewski, Rafael S, Helmink, Beth A, Dominguez, Joseph R, Saunders, Brian T, Ding, Jie, Williams, Jesse W, Jiang, Jean X, Segal, Brahm H, Zinselmeyer, Bernd H, Randolph, Gwendalyn J, Kim, Ki-Wook

“…Two resident macrophage subsets reside in peritoneal fluid. Macrophages also reside within mesothelial membranes lining the peritoneal cavity, but they remain…”
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Lipid absorption and overall intestinal lymphatic transport are impaired following partial small bowel resection in mice by Onufer, Emily J., Czepielewski, Rafael S., Han, Yong-Hyun, Courtney, Cathleen M., Sutton, Stephanie, Sescleifer, Anne, Randolph, Gwendalyn J., Warner, Brad W.

“…Short bowel syndrome (SBS) is associated with diminished levels of serum fats caused by unknown mechanisms. We have shown that mesenteric lymphatics remodel to…”
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EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis by Onufer, Emily J., Aladegbami, Bola, Imai, Toru, Seiler, Kristen, Bajinting, Adam, Courtney, Cathleen, Sutton, Stephanie, Bustos, Aiza, Yao, Junjie, Yeh, Cheng-Hung, Sescleifer, Anne, Wang, Lihong V., Guo, Jun, Warner, Brad W.

“…Background Short bowel syndrome (SBS) results from significant loss of small intestinal length. In response to this loss, adaptation occurs, with Epidermal…”
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A Decade of Firearm Injuries: Children Caught in the Crossfire by Sescleifer, Anne M., Onufer, Emily J., Greenspon, Jose, Keller, Martin S.

“…Firearm injuries (FIs) are the leading cause of preventable morbidity and mortality in pediatric patients. In this study, we aim to define evolving trends and…”
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Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor by Czepielewski, Rafael S., Erlich, Emma C., Onufer, Emily J., Young, Shannon, Saunders, Brian T., Han, Yong-Hyun, Wohltmann, Mary, Wang, Peter L., Kim, Ki-Wook, Kumar, Shashi, Hsieh, Chyi-Song, Scallan, Joshua P., Yang, Ying, Zinselmeyer, Bernd H., Davis, Michael J., Randolph, Gwendalyn J.

“…Lymphangitis and the formation of tertiary lymphoid organs (TLOs) in the mesentery are features of Crohn’s disease. Here, we examined the genesis of these TLOs…”
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Racial disparities in triage of adolescent patients after bullet injury by Andrade, Erin G., Onufer, Emily J., Thornton, Melissa, Keller, Martin S., Schuerer, Douglas J.E., Punch, LJ

“…While pediatric trauma centers (PTCs) and adult trauma centers (ATCs) exhibit equivalent trauma mortality, the optimal care environment for traumatically…”
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SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling by Gu, Wei, Wang, Hua, Huang, Xiaofeng, Kraiczy, Judith, Singh, Pratik N.P., Ng, Charles, Dagdeviren, Sezin, Houghton, Sean, Pellon-Cardenas, Oscar, Lan, Ying, Nie, Yaohui, Zhang, Jiaoyue, Banerjee, Kushal K., Onufer, Emily J., Warner, Brad W., Spence, Jason, Scherl, Ellen, Rafii, Shahin, Lee, Richard T., Verzi, Michael P., Redmond, David, Longman, Randy, Helin, Kristian, Shivdasani, Ramesh A., Zhou, Qiao

“…Adult stem cells maintain regenerative tissue structure and function by producing tissue-specific progeny, but the factors that preserve their tissue…”
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Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species by Han, Jichang, Gallerand, Alexandre, Erlich, Emma C., Helmink, Beth A., Mair, Iris, Li, Xin, Eckhouse, Shaina R., Dimou, Francesca M., Shakhsheer, Baddr A., Phelps, Hannah M., Chan, Mandy M., Mintz, Rachel L., Lee, Daniel D., Schilling, Joel D., Finlay, Conor M., Allen, Judith E., Jakubzick, Claudia V., Else, Kathryn J., Onufer, Emily J., Zhang, Nan, Randolph, Gwendalyn J.

“…In mouse peritoneal and other serous cavities, the transcription factor GATA6 drives the identity of the major cavity resident population of macrophages, with…”
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Effects of high-fat diet on liver injury after small bowel resection by Onufer, Emily J., Han, Yong-Hyun, Czepielewski, Rafael S., Courtney, Cathleen M., Sutton, Stephanie, Randolph, Gwendalyn J., Warner, Brad W.

“…The optimal regimen for enteral nutritional support in the management of children with short bowel syndrome (SBS) is not well characterized. A high fat,…”
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Liver injury after small bowel resection is prevented in obesity-resistant 129S1/SvImJ mice by Onufer, Emily J, Han, Yong-Hyun, Courtney, Cathleen, Steinberger, Allie, Tecos, Maria, Sutton, Stephanie, Sescleifer, Anne, Ou, Jocelyn, Sanguinetti Czepielewski, Rafael, Randolph, Gwendalyn J, Warner, Brad W

“…Intestinal failure-associated liver disease is a major morbidity associated with short bowel syndrome. We sought to determine if the obesity-resistant mouse…”
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Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4 by Courtney, Cathleen M., Onufer, Emily J., McDonald, Keely G., Steinberger, Allie E., Sescleifer, Anne M., Seiler, Kristen M., Tecos, Maria E., Newberry, Rodney D., Warner, Brad W.

“…Short bowel syndrome resulting from small bowel resection (SBR) is associated with significant morbidity and mortality. Many adverse sequelae including…”
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Lymphatic network remodeling after small bowel resection by Onufer, Emily J., Czepielewski, Rafael, Seiler, Kristen M., Erlich, Emma, Courtney, Cathleen M., Bustos, Aiza, Randolph, Gwendalyn J., Warner, Brad W

“…Short gut syndrome (SGS) following massive small bowel resection (SBR) is a major cause of pediatric mortality and morbidity secondary to nutritional…”
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Trauma Technical Skill and Management Exposure for Junior Surgical Residents – The “SAVE Lab 1.0” by Onufer, Emily J., Cullinan, Darren R., Wise, Paul E., Punch, Laurie J.

“…The “Surgery for Abdomino-thoracic ViolencE (SAVE)” animate lab engages surgical residents in the management of complex penetrating injuries. We hypothesized…”
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Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice by Onufer, Emily J., Tay, Shirli, Barron, Lauren K., Courtney, Cathleen M., Warner, Brad W., Guo, Jun

“…Mammalian target of rapamycin complex 1 (mTORC1) is a major regulator of cell growth and proliferation through fuel sensing. Systemic inhibition of mTOR as…”
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An anatomic approach to understanding mechanisms of intestinal adaptation by Courtney, Cathleen M., Onufer, Emily J., Seiler, Kristen M., Warner, Brad W.

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Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection in Mice by Seiler, Kristen M, Waye, Sarah E, Kong, Wenjun, Kamimoto, Kenji, Bajinting, Adam, Goo, William H, Onufer, Emily J, Courtney, Cathleen, Guo, Jun, Warner, Brad W, Morris, Samantha A

“…Background & AimsThe small intestine (SI) displays regionality in nutrient and immunological function. Following SI tissue loss (as occurs in short gut…”
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Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis by Canales-Herrerias, Pablo, Uzzan, Mathieu, Seki, Akihiro, Czepielewski, Rafael S, Verstockt, Bram, Livanos, Alexandra E, Raso, Fiona, Dunn, Alexandra, Dai, Daniel, Wang, Andrew, Al-Taie, Zainab, Martin, Jerome, Laurent, Thomas, Ko, Huaibin M, Tokuyama, Minami, Tankelevich, Michael, Meringer, Hadar, Cossarini, Francesca, Jha, Divya, Krek, Azra, Paulsen, John D, Taylor, Matthew D, Nakadar, Mohammad Zuber, Wong, Joshua, Erlich, Emma C, Mintz, Rachel L, Onufer, Emily J, Helmink, Beth A, Sharma, Keshav, Rosenstein, Adam, Ganjian, Danielle, Chung, Grace, Dawson, Travis, Juarez, Julius, Yajnik, Vijay, Cerutti, Andrea, Faith, Jeremiah J, Suarez-Farinas, Mayte, Argmann, Carmen, Petralia, Francesca, Randolph, Gwendalyn J, Polydorides, Alexandros D, Reboldi, Andrea, Colombel, Jean-Frederic, Mehandru, Saurabh

“…Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1)…”
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TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy by Di Luccia, Blanda, Molgora, Martina, Khantakova, Darya, Jaeger, Natalia, Chang, Hao-Wei, Czepielewski, Rafael S, Helmink, Beth A, Onufer, Emily J, Fachi, José L, Bhattarai, Bishan, Trsan, Tihana, Rodrigues, Patrick F, Hou, JinChao, Bando, Jennifer K, da Silva, Cristiane Sécca, Cella, Marina, Gilfillan, Susan, Schreiber, Robert D, Gordon, Jeffrey I, Colonna, Marco

“…The gut microbiota and tumor-associated macrophages (TAMs) affect tumor responses to anti-programmed cell death protein 1 (PD-1) immune checkpoint blockade…”
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