Search Results - "Emerson, Mark M."

A Gene Regulatory Network Controls the Binary Fate Decision of Rod and Bipolar Cells in the Vertebrate Retina by Wang, Sui, Sengel, Cem, Emerson, Mark M., Cepko, Constance L.

“…Gene regulatory networks (GRNs) regulate critical events during development. In complex tissues, such as the mammalian central nervous system (CNS), networks…”
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Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states by Chen, Xueqing, Emerson, Mark M.

“…Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal…”
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Otx2 and Onecut1 Promote the Fates of Cone Photoreceptors and Horizontal Cells and Repress Rod Photoreceptors by Emerson, Mark M., Surzenko, Natalia, Goetz, Jillian J., Trimarchi, Jeffrey, Cepko, Constance L.

“…Cone photoreceptors carry out phototransduction in daylight conditions and provide the critical first step in color vision. Despite their importance, little is…”
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Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors by Emerson, Mark M., Cepko, Constance L.

“…The homeodomain protein, Otx2, is a critical regulator of vertebrate photoreceptor genesis. However, the genetic elements that define the expression of Otx2…”
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OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification by Ghinia Tegla, Miruna Georgiana, Buenaventura, Diego F, Kim, Diana Y, Thakurdin, Cassandra, Gonzalez, Kevin C, Emerson, Mark M

“…During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly…”
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Lineage tracing analysis of cone photoreceptor associated cis-regulatory elements in the developing chicken retina by Schick, Estie, McCaffery, Sean D., Keblish, Erin E., Thakurdin, Cassandra, Emerson, Mark M.

“…During vertebrate retinal development, transient populations of retinal progenitor cells with restricted cell fate choices are formed. One of these progenitor…”
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Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1 by Jean-Charles, Nathalie, Buenaventura, Diego F, Emerson, Mark M

“…Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of…”
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Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells by Patoori, Sruti, Jean-Charles, Nathalie, Gopal, Ariana, Sulaiman, Sacha, Gopal, Sneha, Wang, Brian, Souferi, Benjamin, Emerson, Mark M

“…The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal…”
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Quantitative analysis of the ThrbCRM1-centered gene regulatory network by Souferi, Benjamin, Emerson, Mark M

“…Enhancer activity is determined by both the activity and occupancy of transcription factors as well as the specific sequences they bind. Experimental…”
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Analysis of thyroid response element activity during retinal development by Billings, Nathan A, Emerson, Mark M, Cepko, Constance L

“…Thyroid hormone (TH) signaling components are expressed during retinal development in dynamic spatial and temporal patterns. To probe the competence of retinal…”
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Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors by Buenaventura, Diego F, Corseri, Adrianne, Emerson, Mark M

“…The early transcriptional events that occur in newly generated cone photoreceptors are not well described. Knowledge of these events is critical to provide…”
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Fate-restricted retinal progenitor cells adopt a molecular profile and spatial position distinct from multipotent progenitor cells by Buenaventura, Diego F., Ghinia-Tegla, Miruna G., Emerson, Mark M.

“…During development, multipotent retinal progenitor cells generate a large number of unique cell types. Recent evidence suggests that there are fate-restricted…”
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Early cis-regulatory events in the formation of retinal horizontal cells by Schick, Estie, Gonzalez, Kevin C., Dutta, Pooja, Hossain, Kazi, Ghinia Tegla, Miruna G., Emerson, Mark M.

“…During retinal development, multipotent and restricted progenitor cells generate all of the neuronal cells of the retina. Among these are horizontal cells,…”
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Identification of cis-regulatory modules for adeno-associated virus-based cell-type-specific targeting in the retina and brain by Lin, Cheng-Hui, Sun, Yue, Chan, Candace S.Y., Wu, Man-Ru, Gu, Lei, Davis, Alexander E., Gu, Baokun, Zhang, Wenlin, Tanasa, Bogdan, Zhong, Lei R., Emerson, Mark M., Chen, Lu, Ding, Jun B., Wang, Sui

“…Adeno-associated viruses (AAVs) targeting specific cell types are powerful tools for studying distinct cell types in the central nervous system (CNS)…”
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Drosophila semaphorin2b is required for the axon guidance of a subset of embryonic neurons by Emerson, Mark M., Long, Jennifer B., Vactor, David Van

“…COVER PHOTOGRAPH: Drosophila embryonic axons visualized for expression of Fasciclin II (red) and a transgene that marks sema‐phorin2b‐positive cells (green)…”
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Drosophila semaphorin2b is required for the axon guidance of a subset of embryonic neurons by Emerson, Mark M., Long, Jennifer B., Van Vactor, David

“…Background: The process of axon guidance is important in establishing functional neural circuits. The differential expression of cell‐autonomous axon guidance…”
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Robust marking of photoreceptor cells and pinealocytes with several reporters under control of the Crx gene by Samson, Maria, Emerson, Mark M., Cepko, Constance L.

“…Crx is a member of the Otx family of homeobox genes with expression restricted to vertebrate retinal photoreceptor and bipolar cells as well as the…”
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Novel Insights into the Regulation of the Timeless Protein by Ashmore, Lesley J, Sathyanarayanan, Sriram, Silvestre, David W, Emerson, Mark M, Schotland, Peter, Sehgal, Amita

“…In the Drosophila circadian clock, period (per) and its partner, timeless (tim), play a central role in the negative limb of an autoregulatory feedback loop…”
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Robo is Abl to block N-Cadherin function by Emerson, Mark M, Van Vactor, David

“…The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory…”
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Structure and Evolution of the Alternatively Spliced Fast Troponin T Isoform Gene by Bucher, E A, Dhoot, G K, Emerson, M M, Ober, M, Emerson, Jr, C P

“…The vertebrate fast skeletal muscle troponin T gene, TnTf , produces a complexity of isoforms through differential mRNA splicing. The mechanisms that regulate…”
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