Search Results - "Emerson, Daniel J"
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Chromatin structure dynamics during the mitosis-to-G1 phase transition
Published in Nature (London) (05-12-2019)“…Features of higher-order chromatin organization—such as A/B compartments, topologically associating domains and chromatin loops—are temporarily disrupted…”
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Cohesin-mediated loop anchors confine the locations of human replication origins
Published in Nature (London) (23-06-2022)“…DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability 1 , 2 . At present, it is unknown…”
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Exchange Often and Properly in Replica Exchange Molecular Dynamics
Published in Journal of chemical theory and computation (14-09-2010)“…Previous work by us showed that in replica exchange molecular dynamics, exchanges should be attempted extremely often, providing gains in efficiency and no…”
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Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries
Published in Cell (20-09-2018)“…More than 25 inherited human disorders are caused by the unstable expansion of repetitive DNA sequences termed short tandem repeats (STRs). A fundamental…”
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A Novel Fluorescent General Anesthetic Enables Imaging of Sites of Action In Vivo
Published in Anesthesiology (Philadelphia) (01-06-2012)Get full text
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Detecting hierarchical genome folding with network modularity
Published in Nature methods (01-02-2018)“…3DNetMod identifies nested topologically associating domains (TADs) and subTADs from Hi-C data. Mammalian genomes are folded in a hierarchy of compartments,…”
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The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries
Published in Molecular cell (06-04-2017)“…Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the treatment of diverse diseases, yet the roles of individual BET family…”
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Fluorescent Anesthetics
Published in Methods in enzymology (2018)“…Methods for using exogenous fluorophore and general anesthetic 1-aminoanthracene (1-AMA) and its photoactive derivative 1-azidoanthracene (1-AZA) are provided…”
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A subset of topologically associating domains fold into mesoscale core-periphery networks
Published in Scientific reports (02-07-2019)“…Mammalian genomes are folded into a hierarchy of compartments, topologically associating domains (TADs), subTADs, and long-range looping interactions. The…”
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Direct Modulation of Microtubule Stability Contributes to Anthracene General Anesthesia
Published in Journal of the American Chemical Society (10-04-2013)“…Recently, we identified 1-aminoanthracene as a fluorescent general anesthetic. To investigate the mechanism of action, a photoactive analogue,…”
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