Search Results - "Embry, Matthew C"

Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide by Wang, Jingyao, Berglund, Mark R., Braden, Timothy, Embry, Matthew C., Johnson, Martin D., Groskreutz, Stephen R., Sayyed, Fareed Bhasha, Tsukanov, Sergey Vladimirovich, White, Timothy D., Jalan, Ankur, Seibert, Kevin D., Kopach, Michael E.

“…This study focused on investigating diketopiperazine (DKP) and the formation of associated double-amino-acid deletion impurities during linear solid-phase…”
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Generation of Hydrogen Cyanide from the Reaction of Oxyma (Ethyl Cyano(hydroxyimino)acetate) and DIC (Diisopropylcarbodiimide) by McFarland, Adam D, Buser, Jonas Y, Embry, Matthew C, Held, Charles B, Kolis, Stanley P

“…Evolution of hydrogen cyanide (HCN) during amino acid activation using the reagent combination ethyl cyano­(hydroxyimino)­acetate…”
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Diastereoselective Pictet-Spengler Based Synthesis of a Chiral Tetrahydroisoquinoline D1 Potentiator by Magnus, Nicholas A, Buser, Jonas Y, Embry, Matthew C, Kallman, Neil J

“…A practical synthesis of a D1 potentiator chiral tetrahydroisoquinoline has been accomplished employing diastereoselective Pictet-Spengler methodology to…”
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Cyclization of Methyl-Coumalate-Derived Methyl 1‑Benzamido-6-oxo-1,6-dihydropyridine-3-carboxylates: Assembly of the [1,2,4]Triazolo[1,5‑a]pyridine Ring System by Moloney, Harold, Magnus, Nicholas A, Buser, Jonas Y, Embry, Matthew C

“…An efficient three-step synthesis of a series of fused bicyclic s-[1,2,4]­triazolo­[1,5-a]­pyridines 1 was accomplished utilizing novel intermediates derived…”
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Development of a Mechanistic Amino Acid Activation Reaction Kinetics Model for Safe and Efficient Solid Phase Peptide Synthesis by Wang, Jingyao, Agrawal, Paridhi, Buser, Jonas Y., Embry, Matthew C., McFarland, Adam D., Berglund, Mark R., McClary Groh, Jennifer, Viswanath, Shekhar K.

“…Amino acid pre-activation is a critical reaction step during solid phase peptide synthesis due in part to the formation of impurities such as isomer,…”
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