Search Results - "Emans, P J"

Spatially resolved endogenous improved metabolite detection in human osteoarthritis cartilage by matrix assisted laser desorption ionization mass spectrometry imaging by Eveque-Mourroux, M R, Emans, P J, Zautsen, R R M, Boonen, A, Heeren, R M A, Cillero-Pastor, B

“…Osteoarthritis (OA) is one of the most common musculoskeletal diseases, characterized by the progressive deterioration of articular cartilage. Although the…”
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The first-generation anatomical medial meniscus prosthesis led to unsatisfactory results: a first-in-human study by van Tienen, T. G., van Minnen, B., Defoort, K. C., Emans, P. J., van de Groes, S. A. W., Verdonschot, N., Jutten, L. M., Pikaart, R. W. E., Heesterbeek, P. J. C.

“…Purpose The purpose of this first-in-human study was to evaluate the effect of a polycarbonate anatomical meniscus prosthesis system, including the surgical…”
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Cartilage repair strategies in the knee according to Dutch Orthopedic Surgeons: a survey study by Jeuken, R. M., van Hugten, P. P. W., Roth, A. K., Boymans, T. A. E. J., Caron, J., Weber, A., Custers, R. J. H., Emans, P. J.

“…Background This study surveyed Dutch orthopedic surgeons on the management of cartilage defects in the knee and the adherence to the recently updated Dutch…”
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Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis by Tellegen, A. R., Rudnik-Jansen, I., Pouran, B., de Visser, H. M., Weinans, H. H., Thomas, R. E., Kik, M. J. L., Grinwis, G. C. M., Thies, J. C., Woike, N., Mihov, G., Emans, P. J., Meij, B. P., Creemers, L. B., Tryfonidou, M. A.

“…Major hallmarks of osteoarthritis (OA) are cartilage degeneration, inflammation and osteophyte formation. COX-2 inhibitors counteract inflammation-related…”
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Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model by Schreinemacher, M. H. F., Emans, P. J., Gijbels, M. J. J., Greve, J.-W. M., Beets, G. L., Bouvy, N. D.

“…Background: In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. In this…”
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Comparison of fixed and mobile-bearing total knee arthroplasty in terms of patellofemoral pain and function: a prospective, randomised, controlled trial by Feczko, P Z, Jutten, L M, van Steyn, M J, Deckers, P, Emans, P J, Arts, J J

“…Despite growing evidence in the literature, there is still a lack of consensus regarding the use of the mobile-bearing (MB) design total knee arthroplasty…”
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Decreased bone tissue mineralization can partly explain subchondral sclerosis observed in osteoarthritis by Cox, L.G.E, van Donkelaar, C.C, van Rietbergen, B, Emans, P.J, Ito, K

“…Abstract For many years, pharmaceutical therapies for osteoarthritis (OA) were focused on cartilage. However, it has been theorized that bone changes such as…”
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Impairment of the chondrogenic phase of endochondral ossification in vivo by inhibition of cyclooxygenase-2 by Janssen, M P, Caron, M M, van Rietbergen, B, Surtel, D A, van Rhijn, L W, Welting, T J, Emans, P J

“…Many studies have reported on the effects of cyclooxygenase-2 (COX-2) inhibition on osteogenesis. However, far less is known about the effects of COX-2…”
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Inhibition of cyclooxygenase-2 impacts chondrocyte hypertrophic differentiation during endochondral ossification by Welting, T J M, Caron, M M J, Emans, P J, Janssen, M P F, Sanen, K, Coolsen, M M E, Voss, L, Surtel, D A M, Cremers, A, Voncken, J W, van Rhijn, L W

“…Skeletogenesis and bone fracture healing involve endochondral ossification, a process during which cartilaginous primordia are gradually replaced by bone…”
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Tissue-engineered constructs: the effect of scaffold architecture in osteochondral repair by Emans, P. J., Jansen, E. J. P., van Iersel, D., Welting, T. J. M., Woodfield, T. B. F., Bulstra, S. K., Riesle, J., van Rhijn, L. W., Kuijer, R.

“…Cartilage has a poor regenerative capacity. Tissue‐engineering approaches using porous scaffolds seeded with chondrocytes may improve cartilage repair. The aim…”
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The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis by Emanuel, K.S., Kellner, L.J., Peters, M.J.M., Haartmans, M.J.J., Hooijmans, M.T., Emans, P.J.

“…Early and non-invasive detection of osteoarthritis (OA) is required to enable early treatment and monitoring of interventions. Some of the earliest signs of OA…”
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Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures by Caron, M.M.J, Emans, P.J, Coolsen, M.M.E, Voss, L, Surtel, D.A.M, Cremers, A, van Rhijn, L.W, Welting, T.J.M

“…Summary Objective Three-dimensional (3D) cultures are widely used to redifferentiate chondrocytes. However, the rationale behind the choice for 3D above…”
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Identification of tissue-dependent proteins in knee OA synovial fluid by Timur, U.T., Jahr, H., Anderson, J., Green, D.C., Emans, P.J., Smagul, A., van Rhijn, L.W., Peffers, M.J., Welting, T.J.M.

“…For many proteins from osteoarthritic synovial fluid, their intra-articular tissue of origin remains unknown. In this study we performed comparative proteomics…”
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Direct comparison of non-osteoarthritic and osteoarthritic synovial fluid-induced intracellular chondrocyte signaling and phenotype changes by Housmans, B.A.C., van den Akker, G.G.H., Neefjes, M., Timur, U.T., Cremers, A., Peffers, M.J., Caron, M.M.J., van Rhijn, L.W., Emans, P.J., Boymans, T.A.E.J., Feczko, P.Z., van der Kraan, P.M., Welting, T.J.M.

“…Since the joint microenvironment and tissue homeostasis are highly dependent on synovial fluid, we aimed to compare the essential chondrocyte signaling…”
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Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7 by Caron, M.M.J, Emans, P.J, Cremers, A, Surtel, D.A.M, Coolsen, M.M.E, van Rhijn, L.W, Welting, T.J.M

“…Summary Objective Bone morphogenic protein (BMP)-2 and BMP-7 are clinically approved and their recombinant proteins are used for bone tissue regenerative…”
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Knee joint distraction compared with total knee arthroplasty: a randomised controlled trial by van der Woude, J A D, Wiegant, K, van Heerwaarden, R J, Spruijt, S, Emans, P J, Mastbergen, S C, Lafeber, F P J G

“…Knee joint distraction (KJD) is a relatively new, knee-joint preserving procedure with the goal of delaying total knee arthroplasty (TKA) in young and…”
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Knee adduction moments are not increased in obese knee osteoarthritis patients during stair negotiation by Verlaan, L., Boekesteijn, R.J., Oomen, P.W., Liu, W.Y., Peters, M.J.M., Emans, P.J., van Rhijn, L.W., Meijer, K.

“…•Knee adduction moment during stair negotiation is not impaired in knee osteoarthritis.•Stance time is increased in obese with knee osteoarthritis during stair…”
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Patient-specific instrumentation in Oxford unicompartmental knee arthroplasty is reliable and accurate except for the tibial rotation by Kerens, B., Leenders, A. M., Schotanus, M. G. M., Boonen, B., Tuinebreijer, W. E., Emans, P. J., Jong, B., Kort, N. P.

“…Purpose Patient-specific instrumentation (PSI) is a technique to plan and position the prosthesis components in unicompartmental knee arthroplasty (UKA)…”
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Cementless versus cemented Oxford unicompartmental knee arthroplasty: early results of a non-designer user group by Kerens, B., Schotanus, M. G. M., Boonen, B., Boog, P., Emans, P. J., Lacroix, H., Kort, N. P.

“…Purpose Although fewer tibial radiolucent lines are observed in cementless Oxford unicompartmental knee arthroplasty (UKA) compared with cemented Oxford UKA,…”
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Revision from unicompartmental to total knee replacement: the clinical outcome depends on reason for revision by Kerens, B, Boonen, B, Schotanus, M G M, Lacroix, H, Emans, P J, Kort, N P

“…Although it has been suggested that the outcome after revision of a unicondylar knee replacement (UKR) to total knee replacement (TKR) is better when the…”
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