Prevalence of Parkinsonism Among Foundry Workers in an Automobile Manufacturing Factory in Tehran

Prevalence of Parkinsonism Among Foundry Workers in an Automobile Manufacturing Factory in Tehran

BackgroundManganese, as an essential element, has neurotoxic effects on basal ganglia and causes parkinsonism, dystonia, and cognitive symptoms in exposed individuals. Transcranial sonography (TCS) is a noninvasive and easily accessible imaging modality for detecting the accumulation of trace elemen...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) Vol. 14; no. 9; p. e28685
Main Authors: Rohani, Mohammad, Kassiri, Negin, Emamikhah Abarghouei, Maziar, Mohammadi, Saber, Labbafinejad, Yasser
Format: Journal Article
Language:English
Published: Palo Alto Cureus Inc 01-09-2022
Cureus
Subjects:
Age
Brain diseases
Confidence intervals
Education
Manufacturing
Mechanics
Neurology
Occupational Health
Preventive Medicine
Quality control
Regression analysis
Shift work
Ultrasonic imaging
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Summary:BackgroundManganese, as an essential element, has neurotoxic effects on basal ganglia and causes parkinsonism, dystonia, and cognitive symptoms in exposed individuals. Transcranial sonography (TCS) is a noninvasive and easily accessible imaging modality for detecting the accumulation of trace elements in the basal ganglia.MethodologyIn a cross-sectional study of foundry workers of one of the automobile manufacturing companies in 2019, the prevalence of parkinsonism was assessed through neurological examination and brain parenchymal sonography or TCS. The prevalence of parkinsonism according to age, smoking, work experience, marital status, and exposure to manganese was determined.ResultsAmong 83 male workers, the prevalence of parkinsonism according to neurological examination, substantia nigra hyperechogenicity on TCS, lentiform nucleus hyperechogenicity, and totally was 33.7%, 9.6%, 10.8%, and 42.2%, respectively. The association between the prevalence of parkinsonism and age, smoking, work experience, marital status, and manganese exposure was evaluated. Parkinsonism according to lentiform nucleus hyperechogenicity was associated with smoking (odds ratio [OR] (95% confidence interval [CI]) = 26.63 (2.38-178.71)) and work experience (OR (95% CI) = 7.18 (0.84-61.32)).ConclusionsAccording to this study, the prevalence of parkinsonism based on neurological examination or brain sonography findings was 42.2%. The implementation of this combined screening method might facilitate earlier detection of affected individuals among manganese-exposed workers.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.28685