Search Results - "Emami, Nima C"

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts by Rashkin, Sara R., Graff, Rebecca E., Kachuri, Linda, Thai, Khanh K., Alexeeff, Stacey E., Blatchins, Maruta A., Cavazos, Taylor B., Corley, Douglas A., Emami, Nima C., Hoffman, Joshua D., Jorgenson, Eric, Kushi, Lawrence H., Meyers, Travis J., Van Den Eeden, Stephen K., Ziv, Elad, Habel, Laurel A., Hoffmann, Thomas J., Sakoda, Lori C., Witte, John S.

“…Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment…”
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Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts by Graff, Rebecca E., Cavazos, Taylor B., Thai, Khanh K., Kachuri, Linda, Rashkin, Sara R., Hoffman, Joshua D., Alexeeff, Stacey E., Blatchins, Maruta, Meyers, Travis J., Leong, Lancelote, Tai, Caroline G., Emami, Nima C., Corley, Douglas A., Kushi, Lawrence H., Ziv, Elad, Van Den Eeden, Stephen K., Jorgenson, Eric, Hoffmann, Thomas J., Habel, Laurel A., Witte, John S., Sakoda, Lori C.

“…Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European…”
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Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms by Emami, Nima C., Kachuri, Linda, Meyers, Travis J., Das, Rajdeep, Hoffman, Joshua D., Hoffmann, Thomas J., Hu, Donglei, Shan, Jun, Feng, Felix Y., Ziv, Elad, Van Den Eeden, Stephen K., Witte, John S.

“…Here we train cis -regulatory models of prostate tissue gene expression and impute expression transcriptome-wide for 233,955 European ancestry men (14,616…”
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Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk by Hoffman, Joshua D, Graff, Rebecca E, Emami, Nima C, Tai, Caroline G, Passarelli, Michael N, Hu, Donglei, Huntsman, Scott, Hadley, Dexter, Leong, Lancelote, Majumdar, Arunabha, Zaitlen, Noah, Ziv, Elad, Witte, John S

“…Breast cancer is the most common solid organ malignancy and the most frequent cause of cancer death among women worldwide. Previous research has yielded…”
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A machine learning approach to optimizing cell-free DNA sequencing panels: with an application to prostate cancer by Cario, Clinton L, Chen, Emmalyn, Leong, Lancelote, Emami, Nima C, Lopez, Karen, Tenggara, Imelda, Simko, Jeffry P, Friedlander, Terence W, Li, Patricia S, Paris, Pamela L, Carroll, Peter R, Witte, John S

“…Cell-free DNA's (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we…”
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Author Correction: Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms by Emami, Nima C., Kachuri, Linda, Meyers, Travis J., Das, Rajdeep, Hoffman, Joshua D., Hoffmann, Thomas J., Hu, Donglei, Shan, Jun, Feng, Felix Y., Ziv, Elad, Van Den Eeden, Stephen K., Witte, John S.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility by Emami, Nima C, Cavazos, Taylor B, Rashkin, Sara R, Cario, Clinton L, Graff, Rebecca E, Tai, Caroline G, Mefford, Joel A, Kachuri, Linda, Wan, Eunice, Wong, Simon, Aaronson, David, Presti, Joseph, Habel, Laurel A, Shan, Jun, Ranatunga, Dilrini K, Chao, Chun R, Ghai, Nirupa R, Jorgenson, Eric, Sakoda, Lori C, Kvale, Mark N, Kwok, Pui-Yan, Schaefer, Catherine, Risch, Neil, Hoffmann, Thomas J, Van Den Eeden, Stephen K, Witte, John S

“…To identify rare variants associated with prostate cancer susceptibility and better characterize the mechanisms and cumulative disease risk associated with…”
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A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences by Hoffmann, Thomas J, Van Den Eeden, Stephen K, Sakoda, Lori C, Jorgenson, Eric, Habel, Laurel A, Graff, Rebecca E, Passarelli, Michael N, Cario, Clinton L, Emami, Nima C, Chao, Chun R, Ghai, Nirupa R, Shan, Jun, Ranatunga, Dilrini K, Quesenberry, Charles P, Aaronson, David, Presti, Joseph, Wang, Zhaoming, Berndt, Sonja I, Chanock, Stephen J, McDonnell, Shannon K, French, Amy J, Schaid, Daniel J, Thibodeau, Stephen N, Li, Qiyuan, Freedman, Matthew L, Penney, Kathryn L, Mucci, Lorelei A, Haiman, Christopher A, Henderson, Brian E, Seminara, Daniela, Kvale, Mark N, Kwok, Pui-Yan, Schaefer, Catherine, Risch, Neil, Witte, John S

“…A genome-wide association study (GWAS) of prostate cancer in Kaiser Permanente health plan members (7,783 cases, 38,595 controls; 80.3% non-Hispanic white,…”
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Tissue Sources for Accurate Measurement of Germline DNA Genotypes in Prostate Cancer Patients Treated With Radical Prostatectomy by Emami, Nima C., Leong, Lancelote, Wan, Eunice, Van Blarigan, Erin L., Cooperberg, Matthew R., Tenggara, Imelda, Carroll, Peter R., Chan, June M., Witte, John S., Simko, Jeffry P.

“…BACKGROUND Benign tissue from a tumor‐containing organ is commonly the only available source for obtaining a patient's unmutated genome for use in cancer…”
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Abstract 2968: Imputation of the prostate cancer transcriptome in over 230,000 men reveals novel germline-somatic interaction mechanism of cancer risk by Emami, Nima C., Hoffman, Joshua, Ziv, Elad, Witte, John S.

“…Although genome-wide association studies of prostate cancer have revealed numerous genetic loci associated with disease risk, efforts to characterize the…”
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Age-of-onset information helps identify 76 genetic variants associated with allergic disease by Ferreira, Manuel A R, Vonk, Judith M, Baurecht, Hansjörg, Marenholz, Ingo, Tian, Chao, Hoffman, Joshua D, Helmer, Quinta, Tillander, Annika, Ullemar, Vilhelmina, Lu, Yi, Grosche, Sarah, Rüschendorf, Franz, Granell, Raquel, Brumpton, Ben M, Fritsche, Lars G, Bhatta, Laxmi, Gabrielsen, Maiken E, Nielsen, Jonas B, Zhou, Wei, Hveem, Kristian, Langhammer, Arnulf, Holmen, Oddgeir L, Løset, Mari, Abecasis, Gonçalo R, Willer, Cristen J, Emami, Nima C, Cavazos, Taylor B, Witte, John S, Szwajda, Agnieszka, Hinds, David A, Hübner, Norbert, Weidinger, Stephan, Magnusson, Patrik Ke, Jorgenson, Eric, Karlsson, Robert, Paternoster, Lavinia, Boomsma, Dorret I, Almqvist, Catarina, Lee, Young-Ae, Koppelman, Gerard H

“…Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to…”
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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility by Kachuri, Linda, Johansson, Mattias, Rashkin, Sara R., Graff, Rebecca E., Bossé, Yohan, Manem, Venkata, Caporaso, Neil E., Landi, Maria Teresa, Christiani, David C., Vineis, Paolo, Liu, Geoffrey, Scelo, Ghislaine, Zaridze, David, Shete, Sanjay S., Albanes, Demetrius, Aldrich, Melinda C., Tardón, Adonina, Rennert, Gad, Chen, Chu, Goodman, Gary E., Doherty, Jennifer A., Bickeböller, Heike, Field, John K., Davies, Michael P., Dawn Teare, M., Kiemeney, Lambertus A., Bojesen, Stig E., Haugen, Aage, Zienolddiny, Shanbeh, Lam, Stephen, Le Marchand, Loïc, Cheng, Iona, Schabath, Matthew B., Duell, Eric J., Andrew, Angeline S., Manjer, Jonas, Lazarus, Philip, Arnold, Susanne, McKay, James D., Emami, Nima C., Warkentin, Matthew T., Brhane, Yonathan, Obeidat, Ma’en, Martin, Richard M., Relton, Caroline, Davey Smith, George, Haycock, Philip C., Amos, Christopher I., Brennan, Paul, Witte, John S., Hung, Rayjean J.

“…Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the…”
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Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer by Hoffmann, Thomas J., Passarelli, Michael N., Graff, Rebecca E., Emami, Nima C., Sakoda, Lori C., Jorgenson, Eric, Habel, Laurel A., Shan, Jun, Ranatunga, Dilrini K., Quesenberry, Charles P., Chao, Chun R., Ghai, Nirupa R., Aaronson, David, Presti, Joseph, Nordström, Tobias, Wang, Zhaoming, Berndt, Sonja I., Chanock, Stephen J., Mosley, Jonathan D., Klein, Robert J., Middha, Mridu, Lilja, Hans, Melander, Olle, Kvale, Mark N., Kwok, Pui-Yan, Schaefer, Catherine, Risch, Neil, Van Den Eeden, Stephen K., Witte, John S.

“…Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa—such as…”
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Abstract 1316: Germline genetic signals across multiple aggressive prostate cancer phenotypes by Tai, Caroline G., Emami, Nima C., Hoffmann, Thomas J., Sakoda, Lori C., Jorgenson, Eric, Habel, Laurel A., Shan, Jun, Ranatunga, Dilrini K., Chao, Chun R., Ghai, Nirupa R., Aaronson, David, Presti, Joseph, Schaefer, Catherine, Risch, Neil, Eeden, Stephen K. Van Den, Witte, John S.

“…Prostate cancer (PrCa) is documented to be highly heritable. But many known prostate cancer loci are not associated with aggressive prostate cancer phenotypes…”
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Abstract 1297: Genetic reclassification of prostate-specific antigen levels for personalized prostate cancer screening by Graff, Rebecca E., Hoffmann, Thomas J., Passarelli, Michael N., Emami, Nima C., Sakoda, Lori C., Jorgenson, Eric, Habel, Laurel A., Shan, Jun, Ranatunga, Dilrini K., Quesenberry, Charles P., Chao, Chun R., Ghai, Nirupa R., Aaronson, David, Presti, Joseph, Nordström, Tobias, Wang, Zhaoming, Berndt, Sonja I., Chanock, Stephen J., Mosley, Jonathan D., Klein, Robert J., Middha, Mridu, Lilja, Hans, Melander, Olle, Kvale, Mark N., Kwok, Pui-Yan, Schaefer, Catherine, Risch, Neil, Eeden, Stephen K. Van Den, Witte, John S.

“…Background: Prostate-specific antigen (PSA) screening for prostate cancer results missed diagnoses as well as many unnecessary biopsies and their associated…”
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