Search Results - "Elzi, David J."

Plasminogen activator inhibitor 1 - insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence by Elzi, David J, Lai, Yanlai, Song, Meihua, Hakala, Kevin, Weintraub, Susan T, Shiio, Yuzuru

“…Cellular senescence is widely believed to play a key role in tumor suppression, but the molecular pathways that regulate senescence are only incompletely…”
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Wnt Antagonist SFRP1 Functions as a Secreted Mediator of Senescence by Elzi, David J., Song, Meihua, Hakala, Kevin, Weintraub, Susan T., Shiio, Yuzuru

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth by Zhou, Fuchun, Elzi, David J., Jayabal, Panneerselvam, Ma, Xiuye, Chiu, Yu-Chiao, Chen, Yidong, Blackman, Barron, Weintraub, Susan T., Houghton, Peter J., Shiio, Yuzuru

“…We report here that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6), a member of the bone morphogenetic protein (BMP) family of…”
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Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors by Silliman, Christopher C., Boshkov, Lynn K., Mehdizadehkashi, Zahra, Elzi, David J., Dickey, William O., Podlosky, Linda, Clarke, Gwen, Ambruso, Daniel R.

“…Transfusion-related acute lung injury (TRALI) is a life-threatening complication of hemotherapy. We report a series of 90 TRALI reactions in 81 patients…”
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Proteomic Analysis of the EWS-Fli‑1 Interactome Reveals the Role of the Lysosome in EWS-Fli‑1 Turnover by Elzi, David J, Song, Meihua, Hakala, Kevin, Weintraub, Susan T, Shiio, Yuzuru

“…Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family…”
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NFX1 Interacts with mSin3A/Histone Deacetylase To Repress hTERT Transcription in Keratinocytes by Xu, Mei, Luo, Weifeng, Elzi, David J., Grandori, Carla, Galloway, Denise A.

“…ERRATUM ( vol. 28 , p. 5825 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma by Elzi, David J, Song, Meihua, Houghton, Peter J, Chen, Yidong, Shiio, Yuzuru

“…Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family…”
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A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release by Wyman, Travis H, Bjornsen, A Jason, Elzi, David J, Smith, C Wayne, England, Kelly M, Kelher, Marguerite, Silliman, Christopher C

“…Lysophosphatidylcholines (lyso-PCs), generated during blood storage, are etiologic in a two-insult, sepsis-based model of transfusion-related acute lung injury…”
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Role of galactose in cellular senescence by Elzi, David J., Song, Meihua, Shiio, Yuzuru

“…Cellular senescence has been proposed to play critical roles in tumor suppression and organismal aging, but the molecular mechanism of senescence remains…”
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Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium by Silliman, Christopher C., Elzi, David J., Ambruso, Daniel R., Musters, Rene J., Hamiel, Christine, Harbeck, Ronald J., Paterson, Andrew J., Bjornsen, A. Jason, Wyman, Travis H., Kelher, Marguerite, England, Kelly M., McLaughlin‐Malaxecheberria, Nathan, Barnett, Carlton C., Aiboshi, Junichi, Bannerjee, Anirban

“…A mixture of lysophosphatidylcholines (lyso‐PCs) are generated during blood storage and are etiologic in models of acute lung injury. We hypothesize that…”
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Identification of a novel mechanism for meso‐tetra (4‐carboxyphenyl) porphyrin (TCPP) uptake in cancer cells by Elzi, David J., Bauta, William E., Sanchez, Jamila R., Das, Trisha, Mogare, Shweta, Zannes Fatland, Peter, Iza, Moises, Pertsemlidis, Alexander, Rebel, Vivienne I.

“…Porphyrins are used for cancer diagnostic and therapeutic applications, but the mechanism of how porphyrins accumulate in cancer cells remains elusive…”
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Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury by Silliman, Christopher C., Moore, Ernest E., Kelher, Marguerite R., Khan, Samina Y., Gellar, Lauren, Elzi, David J.

“…BACKGROUND: Lipids accumulate during the storage of red blood cells (RBCs), prime neutrophils (PMNs), and have been implicated in transfusion‐related acute…”
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Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation by Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., West, F. Bernadette, McLaughlin, Nathan J.D., Elzi, David J., England, Kelly, Bjornsen, Jason, Kuldanek, Susan A., Banerjee, Anirban

“…BACKGROUND Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored…”
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LysoPCs induce Hck‐ and PKCδ‐mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils by Kelher, Marguerite R., McLaughlin, Nathan J. D., Banerjee, Anirban, Elzi, David J., Gamboni, Fabia, Khan, Samina Y., Meng, Xianzhong, Mitra, Sanchayita, Silliman, Christopher C.

“…Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion‐related acute lung injury (TRALI)…”
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Axonal outgrowth and Erk1/2 activation by training after spinal cord injury in rats by Oh, Myung-Jin, Seo, Tae Beom, Kwon, Ku-Birm, Yoon, Sung-Jin, Elzi, David J, Kim, Byung G, Namgung, Uk

“…Abstract Physical training in experimental animals can improve locomotor activity via the regulation of spinal neural circuitry or peripheral nerve…”
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FGF19 functions as autocrine growth factor for hepatoblastoma by Elzi, David J, Song, Meihua, Blackman, Barron, Weintraub, Susan T, López-Terrada, Dolores, Chen, Yidong, Tomlinson, Gail E, Shiio, Yuzuru

“…Hepatoblastoma is the most common liver cancer in children, accounting for over 65% of all childhood liver malignancies. Hepatoblastoma is distinct from adult…”
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Leukotriene b4 and its metabolites prime the neutrophil oxidase and induce proinflammatory activation of human pulmonary microvascular endothelial cells by Eun, John C, Moore, Ernest E, Banerjee, Anirban, Kelher, Marguerite R, Khan, Samina Y, Elzi, David J, McLaughlin, Nathan J D, Silliman, Christopher C

“…Leukotrienes are proinflammatory lipid mediators, derived from arachidonic acid via 5-lipoxygenase (5-LO). Leukotriene B4 (LTB4) is an effective…”
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Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils by Elzi, D J, Bjornsen, A J, MacKenzie, T, Wyman, T H, Silliman, C C

“…Many receptor-linked agents that prime or activate the NADPH oxidase in polymorphonuclear neutrophils (PMNs) elicit changes in cytosolic Ca2+ concentration and…”
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Abstract 1223: Simultaneous knockdown of CD320 and LRP2 receptors is selectively toxic to cancer cells but not normal cells by Elzi, David J., Bauta, William, Lai, Shao-Chiang, Das, Trisha, Mogare, Shweta, Rebel, Vivienne I.

“…Designing effective therapies with selective toxicity in cancer cells is a priority of cancer research. Porphyrins are known to selectively accumulate in…”
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Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils by Kelher, Marguerite R, Ambruso, Daniel R, Elzi, David J, Anderson, Steven M, Paterson, Andrew J, Thurman, Gail W, Silliman, Christopher C

“…Chemoattractant priming and activation of PMNs results in changes in cytosolic Ca 2+ concentration, tyrosine kinase activity, and gene expression. We…”
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