Assessment of the Serum Ischemia Modified Albumin Level and Its Relation to Total Oxidant Status and Disease Activity in Vitiligo Patients
Abstract Background Vitiligo is an acquired depigmentary skin disorder characterized by loss of functioning epidermal melanocytes. Oxidative stress has been suggested to be the initial pathogenic event in melanocyte degeneration. Total oxidant status (TOS) had been reflect the global status of oxida...
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| Published in: | QJM : An International Journal of Medicine Vol. 116; no. Supplement_1 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
23-08-2023
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| Online Access: | Get full text |
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| Summary: | Abstract
Background
Vitiligo is an acquired depigmentary skin disorder characterized by loss of functioning epidermal melanocytes. Oxidative stress has been suggested to be the initial pathogenic event in melanocyte degeneration. Total oxidant status (TOS) had been reflect the global status of oxidative stress in serum. While, albumin acts as a buffering agent for toxic molecules within the circulation. It undergoes structural changes when exposed to ischemia or oxidative stress and ischemia modified albumin IMA are produced under these conditions with high levels. Hence it considered as a marker of oxidative stress in different clinical conditions.
Aim of the Work
The aim of this work was to evaluate the serum level of ischemia modified albumin in vitiligo patients and its relation to total oxidant status and disease activity.
Patients and Methods
This is a cross sectional study. Forty-eight patients with vitiligo were included in this study. Twenty-four were considered active cases while the other 24 were non-active vitiligo patients. The study also included 48 age-and sex-matched healthy adults as a control group. Five ml of venous blood were withdrawn from each patient and control subjects. The vitiligo activity and tensity were assessed by VIDA and VETI scores respectively. Serum IMA and TOS had been assist by ELISA kits.
Results
Our study found a significant increase in serum total oxidant status (TOS) and serum ischemia-modified albumin (IMA) levels in vitiligo patients compared to controls. We also found a positive correlation between TOS levels and IMA levels and vitiligo disease activity represented by VIDA score.
Conclusion
The total oxidant status (TOS) and IMA levels were increased in vitiligo patients' sera and positively correlated to disease activity. To the best of our knowledge, we were the first to detect the significantly positive correlation between serum IMA and vitiligo disease activity. |
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| ISSN: | 1460-2725 1460-2393 |
| DOI: | 10.1093/qjmed/hcad069.230 |