Search Results - "Elz, Aurelia S."

Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport by Elz, Aurelia S., Trevaskis, Natalie L., Porter, Christopher J.H., Bowen, Joanne M., Prestidge, Clive A.

“…Challenges to effective delivery of drugs following oral administration has attracted growing interest over recent decades. Small molecule drugs (<1000 Da) are…”
Get full text

Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic by Meola, Tahlia R., Kamath, Srinivas, Elz, Aurelia S., Prestidge, Clive A., Wignall, Anthony, Joyce, Paul

“…Formulation-induced microbiota changes were linked with pro-inflammatory response. [Display omitted] •Amorphous solid dispersion and lipid nanoemulsion improve…”
Get full text

Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury by Nguyen, Triet P. M., Woods, Susan L., Secombe, Kate R., Tang, Simon, Elz, Aurelia S., Ayton, Scott, Finnie, John, Nagpal, Aadya, Pouliot, Normand, Bowen, Joanne M.

“…Purpose Neratinib, a small-molecule tyrosine kinase inhibitor (TKI) that irreversibly binds to human epidermal growth factor receptors 1, 2 and 4 (HER1/2/4),…”
Get full text

Effects of a novel toll-like receptor 4 antagonist IAXO-102 in a murine model of chemotherapy-induced gastrointestinal toxicity by Tam, Janine S. Y., Crame, Elise E., Elz, Aurelia S., Coller, Janet K., Wignall, Anthony, Prestidge, Clive A., Bowen, Joanne M.

“…Introduction Gastrointestinal mucositis (GIM) is a side effect of high-dose irinotecan (CPT-11), causing debilitating symptoms that are often poorly managed…”
Get full text

Therapeutic Potential of Inulin‐Coated MCT Microcapsules in Modulating the Gut Microbiome for Effective Treatment of Diet‐Induced Obesity by Ariaee, Amin, Wardill, Hannah R., Wignall, Anthony, Elz, Aurelia S., Wright, Leah, Prestidge, Clive, Joyce, Paul

“…Obesity, a global epidemic, leads to metabolic dysregulation and systemic inflammation. Recently, therapies targeting the gut microbiome have garnered…”
Get full text