Artemether in the treatment of falciparum malaria during pregnancy in eastern Sudan

This study was carried in New Halfa Hospital, eastern Sudan from October 1997 to February 2001. Twenty-eight pregnant Sudanese women infected with Plasmodium falciparum were treated with intramuscular artemether (six injections, 480 mg) after failure of chloroquine and quinine therapy. The patients...

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Bibliographic Details
Published in:	Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 98; no. 9; pp. 509 - 513
Main Authors:	Adam, Ishag, Elwasila, Eltaib, Mohammed Ali, Daw Alnour, Elansari, Elhassan, Elbashir, Mustafa Idris
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-09-2004 Royal Society of Tropical Medicine and Hygiene Elsevier
Subjects:	Adult Antimalarials - administration & dosage Artemether Artemisinins - administration & dosage Biological and medical sciences Birth Weight Falciparum malaria Female Human protozoal diseases Humans Infectious diseases Injections, Intramuscular Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - epidemiology Medical sciences Neonates Parasitic diseases Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - epidemiology Pregnancy Outcome Protozoal diseases Sesquiterpenes - administration & dosage Sudan Sudan - epidemiology Treatment Outcome Africa Sudan Pregnancy Neonates Artemether Falciparum malaria Sudan Human Protozoa Antimalarial Apicomplexa Protozoal disease Malaria Parasitosis Infection Plasmodium falciparum Chemotherapy Newborn Treatment Parasiticide Tropical medicine
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Summary:	This study was carried in New Halfa Hospital, eastern Sudan from October 1997 to February 2001. Twenty-eight pregnant Sudanese women infected with Plasmodium falciparum were treated with intramuscular artemether (six injections, 480 mg) after failure of chloroquine and quinine therapy. The patients were followed-up until delivery; the babies were followed-up until the age of 1 year. Artemether was given to one patient in the tenth week of gestation, to 12 during the second trimester, and to 15 during the third trimester. It was well tolerated, the parasitaemia was cleared and the patients were symptom-free within three days. One patient (3.5%) delivered at 32 weeks and the baby died six hours after delivery. The other 27 (96.5%) delivered full-term live babies. None of the pregnant women died and there was no abortion, stillbirth or congenital abnormalities in the newborn babies.
Bibliography:	ark:/67375/HXZ-SVQ4CL8X-M istex:7C0E1116EA6EF0B235453B05479708B3C010F779 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0035-9203 1878-3503
DOI:	10.1016/j.trstmh.2003.11.008