Search Results - "Elwali, Nasr Eldin"
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Leveraging Therapeutic Proteins and Peptides from Lumbricus Earthworms: Targeting SOCS2 E3 Ligase for Cardiovascular Therapy through Molecular Dynamics Simulations
Published in International journal of molecular sciences (01-10-2024)“…Suppressor of cytokine signaling 2 (SOCS2), an E3 ubiquitin ligase, regulates the JAK/STAT signaling pathway, essential for cytokine signaling and immune…”
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J1-M267 Y lineage marks climate-driven pre-historical human displacements
Published in European journal of human genetics : EJHG (01-11-2009)“…The present day distribution of Y chromosomes bearing the haplogroup J1 M267(*)G variant has been associated with different episodes of human demographic…”
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Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni: IFN-gamma is associated with protection against fibrosis and TNF-alpha with aggravation of disease
Published in The Journal of immunology (1950) (15-07-2002)“…Hepatic periportal fibrosis, which affects 5-10% of subjects infected by Schistosoma mansoni, is caused by the T cell-dependent granuloma that develop around…”
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Pattern and predictors of neurological morbidities among childhood cerebral malaria survivors in central Sudan
Published in Journal of vector borne diseases (01-09-2015)“…Cerebral malaria is considered a leading cause of neuro-disability in sub-Saharan Africa among children and about 25% of survivors have long-term neurological…”
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Interleukin-13 in the skin and interferon-γ in the liver are key players in immune protection in human schistosomiasis
Published in Immunological reviews (01-10-2004)“…Immunity against schistosomes includes anti‐infection immunity, which is mainly active against invading larvae in the skin, and anti‐disease immunity, which…”
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Pancreatic cancer in Saudi Arabia (2005-2020): increasing trend
Published in BMC cancer (29-05-2024)“…Pancreatic cancer, a highly fatal malignancy, has shown a global rise in the incidence and mortality rates. However, these rates vary significantly across…”
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IFN-gamma polymorphisms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni)
Published in The Journal of immunology (1950) (15-11-2003)“…Schistosome infection is a major public health concern affecting millions of people living in tropical regions of Africa, Asia, and South America. Schistosomes…”
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Factors controlling the effect of praziquantel on liver fibrosis in Schistosoma mansoni-infected patients
Published in FEMS immunology and medical microbiology (01-02-2010)“…An association study of a cohort of 177 Sudanese patients infected with Schistosoma mansoni [82 (46%) males and 95 (54%) females] was conducted to evaluate the…”
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Clinical Presentation and Outcome of Retinoblastoma among Children Treated at the National Cancer Institute (NCI) in Gezira, Sudan: A single institution experience
Published in Ophthalmic genetics (01-06-2011)“…Background: Retinoblastoma (RB) is a rare and unique cancer that affects the eyes of very young children. There are few reports on RB in Sudan. Materials and…”
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Susceptibility to Periportal (Symmers) Fibrosis in Human Schistosoma mansoni Infections: Evidence That Intensity and Duration of Infection, Gender, and Inherited Factors Are Critical in Disease Progression
Published in The Journal of infectious diseases (01-10-1999)“…Lethal disease in Schistosoma mansoni infections is mostly due to portal hypertension caused by hepatic periportal fibrosis. To evaluate the factors that may…”
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Cancer in the Sudan: An overview of the current status of knowledge on tumor patterns and risk factors
Published in The Science of the total environment (15-04-2012)“…The Sudan, the largest and most diverse country in Africa, is experiencing a growing cancer problem, but little is presently known on tumor patterns, cancer…”
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IL‐22 and IL‐22 binding protein (IL‐22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections
Published in Hepatology (Baltimore, Md.) (01-04-2015)“…Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL‐22 may also cause…”
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Germline TP53 mutation spectrum in Sudanese premenopausal breast cancer patients: correlations with reproductive factors
Published in Breast cancer research and treatment (01-06-2019)“…Purpose The role of non-genetic factors as modifiers of TP53 -related hereditary breast cancer (BC) risk is debated. In this regard, little is known about the…”
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Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer
Published in Histopathology (01-10-2012)“…Faggad A, Kasajima A, Weichert W, Stenzinger A, Elwali N E, Dietel M & Denkert C (2012) Histopathology 61, 552–561 Down‐regulation of the microRNA processing…”
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Environment and immune-mediated diseases in Sub-Saharan Africa
Published in The Science of the total environment (15-04-2012)Get full text
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Topoisomerase IIα mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis
Published in Modern pathology (01-04-2009)“…Topoisomerase II α (Top II α ) is a nuclear enzyme that plays a central role in DNA metabolism, and is a molecular target for a variety of chemotherapeutic…”
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Basal-Like Phenotype in a Breast Carcinoma Case Series from Sudan: Prevalence and Clinical/Pathological Correlations
Published in Pathology Research International (09-01-2011)“…Basal-like breast cancer, an aggressive subtype associated with high grade, poor prognosis, and younger age, is reported frequently in Africa. We analyzed the…”
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Colorectal Cancer in Saudi Arabia: The Way Forward
Published in Asian Pacific journal of cancer prevention : APJCP (01-01-2023)“…Colorectal cancer is the most common cancer in Saudi males and the second most common cancer in Saudi females with increasing incidence throughout the last…”
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Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes
Published in The Journal of experimental medicine (26-10-2009)“…Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus and schistosome infections. Hepatic…”
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Signatures of the preagricultural peopling processes in sub-Saharan Africa as revealed by the phylogeography of early Y chromosome lineages
Published in Molecular biology and evolution (01-09-2011)“…The study of Y chromosome variation has helped reconstruct demographic events associated with the spread of languages, agriculture, and pastoralism in…”
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