Search Results - "Elstrom, Rebecca L."

Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma by Clozel, Thomas, Yang, ShaoNing, Elstrom, Rebecca L, Tam, Wayne, Martin, Peter, Kormaksson, Matthias, Banerjee, Samprit, Vasanthakumar, Aparna, Culjkovic, Biljana, Scott, David W, Wyman, Sarah, Leser, Micheal, Shaknovich, Rita, Chadburn, Amy, Tabbo, Fabrizio, Godley, Lucy A, Gascoyne, Randy D, Borden, Katherine L, Inghirami, Giorgio, Leonard, John P, Melnick, Ari, Cerchietti, Leandro

“…Although aberrant DNA methylation patterning is a hallmark of cancer, the relevance of targeting DNA methyltransferases (DNMT) remains unclear for most tumors…”
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Akt stimulates aerobic glycolysis in cancer cells by ELSTROM, Rebecca L, BAUER, Daniel E, THOMPSON, Craig B, BUZZAI, Monica, KARNAUSKAS, Robyn, HARRIS, Marian H, PLAS, David R, HONGMING ZHUANG, CINALLI, Ryan M, ALAVI, Abass, RUDIN, Charles M

“…Cancer cells frequently display high rates of aerobic glycolysis in comparison to their nontransformed counterparts, although the molecular basis of this…”
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Rituximab and three dexamethasone cycles provide responses similar to splenectomy in women and those with immune thrombocytopenia of less than two years duration by Bussel, James B, Lee, Christina S, Seery, Caroline, Imahiyerobo, Allison A, Thompson, Michaela V, Catellier, Diane, Turenne, Ithamar G, Patel, Vivek L, Basciano, Paul A, Elstrom, Rebecca L, Ghanima, Waleed

“…Adults with newly diagnosed or persistent immunothrombocytopenia frequently relapse upon tapering steroids; adults and children with chronic disease have an…”
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The CD28 Signaling Pathway Regulates Glucose Metabolism by Frauwirth, Kenneth A, Riley, James L, Harris, Marian H, Parry, Richard V, Rathmell, Jeffrey C, Plas, David R, Elstrom, Rebecca L, June, Carl H, Thompson, Craig B

“…Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation that increases metabolic demand. Although T cells increase glucose…”
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Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma by Rathmell, Jeffrey C., Elstrom, Rebecca L., Cinalli, Ryan M., Thompson, Craig B.

“…The mechanisms that regulate basal T cell size and metabolic activity are uncertain. Since the phosphatidylinositol‐3 phosphate kinase (PI3 K) and Akt (PKB)…”
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Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma by Wilson, Wyndham H, Young, Ryan M, Schmitz, Roland, Yang, Yandan, Pittaluga, Stefania, Wright, George, Lih, Chih-Jian, Williams, P Mickey, Shaffer, Arthur L, Gerecitano, John, de Vos, Sven, Goy, Andre, Kenkre, Vaishalee P, Barr, Paul M, Blum, Kristie A, Shustov, Andrei, Advani, Ranjana, Fowler, Nathan H, Vose, Julie M, Elstrom, Rebecca L, Habermann, Thomas M, Barrientos, Jacqueline C, McGreivy, Jesse, Fardis, Maria, Chang, Betty Y, Clow, Fong, Munneke, Brian, Moussa, Davina, Beaupre, Darrin M, Staudt, Louis M

“…Clinical testing of BCR inhibition on DLBCL reveals determinants of response. The two major subtypes of diffuse large B cell lymphoma (DLBCL)—activated B…”
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Metronomic therapy for refractory/relapsed lymphoma: the PEP-C low-dose oral combination chemotherapy regimen by Coleman, Morton, Ruan, Gia, Elstrom, Rebecca L, Martin, Peter, Leonard, John P

“…Metronomic therapy is the application of continuous, low dose chemotherapy. The doses of chemotherapy are usually not sufficient to destroy neoplastic cells,…”
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PET Imaging of Lymphoma by Elstrom, Rebecca L., MD, Schuster, Stephen J., MD

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New Biologic Agents and Immunologic Strategies by Elstrom, Rebecca L., MD, Martin, Peter, MD, Leonard, John P., MD

“…The treatment of non-Hodgkin lymphoma has traditionally consisted of cytotoxic chemotherapy, which can frequently induce remissions but less reliably delivers…”
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The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation by BUZZAI, Monica, BAUER, Daniel E, JONES, Russell G, DEBERARDINIS, Ralph J, HATZIVASSILIOU, Georgia, ELSTROM, Rebecca L, THOMPSON, Craig B

“…Activation of the oncogenic kinase Akt stimulates glucose uptake and metabolism in cancer cells and renders these cells susceptible to death in response to…”
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Response assessment in lymphoma: time to lower the bar? by Elstrom, Rebecca L.

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Interim response assessment for Hodgkin lymphoma: size matters by Elstrom, Rebecca L.

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Autologous stem cell transplant is feasible in very elderly patients with lymphoma and limited comorbidity by Elstrom, Rebecca L., Martin, Peter, Rua, Sandra Hurtado, Shore, Tsiporah B., Furman, Richard R., Ruan, Jia, Pearse, Roger N., Coleman, Morton, Mark, Tomer, Leonard, John P., Gergis, Usama

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Bortezomib in combination with rituximab, dexamethasone, ifosfamide, cisplatin and etoposide chemoimmunotherapy in patients with relapsed and primary refractory diffuse large B-cell lymphoma by Elstrom, Rebecca L., Andemariam, Biree, Martin, Peter, Ruan, Jia, Shore, Tsiporah B., Coleman, Morton, Leonard, John P., Furman, Richard R.

“…Abstract Patients with relapsed or refractory diffuse large B-cell lymphoma may experience extended survival with second-line chemotherapy and autologous stem…”
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Response to Second-line Therapy Defines the Potential for Cure in Patients With Recurrent Diffuse Large B-Cell Lymphoma: Implications for the Development of Novel Therapeutic Strategies by Elstrom, Rebecca L, Martin, Peter, Ostrow, Katya, Barrientos, Jacqueline, Chadburn, Amy, Furman, Richard, Ruan, Jia, Shore, Tsiporah, Schuster, Michael, Cerchietti, Leandro, Melnick, Ari, Coleman, Morton, Leonard, John P

“…Abstract Background Patients with diffuse large B-cell lymphoma (DLBCL) who are not cured by initial therapy sometimes experience disease-free survival after…”
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Phase 1 study of radiosensitization using bortezomib in patients with relapsed non-Hodgkin lymphoma receiving radioimmunotherapy with 131I-tositumomab by Elstrom, Rebecca L., Ruan, Jia, Christos, Paul J., Martin, Peter, Lebovic, Daniel, Osborne, Joseph, Goldsmith, Stanley, Greenberg, June, Furman, Richard R., Avram, Anca, Putman, Ryan, Chapman, Erica, Mazumdar, Madhu, Griffith, Kent, Coleman, Morton, Leonard, John P., Kaminski, Mark S.

“…Abstract Radioimmunotherapy (RIT) is effective treatment for indolent non-Hodgkin lymphomas (NHLs), but response durations are usually limited, especially in…”
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FDG-PET in prediction of splenectomy findings in patients with known or suspected lymphoma by Rutherford, Sarah C., Andemariam, Biree, Philips, Shibu M., Elstrom, Rebecca L., Chadburn, Amy, Furman, Richard R., Niesvizky, Ruben, Martin, Peter, Fahey, Thomas J., Coleman, Morton, Goldsmith, Stanley J., Leonard, John P.

“…Diagnostic splenectomy is frequently performed in patients with suspected or known lymphoma. We evaluated whether preoperative 18F-fluorodeoxyglucose positron…”
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FDG-PET scans in patients with lymphoma by Elstrom, Rebecca L., Leonard, John P.

“…Lymphoma comprises a complex set of diseases, including Hodgkin and non-Hodgkin subtypes. An expected goal of management is chronic disease control over…”
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Enhanced Marrow [18F]Fluorodeoxyglucose Uptake Related to Myeloid Hyperplasia in Hodgkin's Lymphoma Can Simulate Lymphoma Involvement in Marrow by Elstrom, Rebecca L., Tsai, Donald E., Vergilio, Jo-Anne, Downs, Lisa H., Alavi, Abass, Schuster, Stephen J.

“…[18F]Fluorodeoxyglucose (FDG) positron emission tomography (PET) is increasingly used for the clinical staging of lymphomas and for assessment of response to…”
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Trial in progress: A phase III, randomized, open-label study comparing zanubrutinib plus rituximab versus bendamustine plus rituximab in patients with previously untreated mantle cell lymphoma (MCL) by Dreyling, Martin H., Tam, Constantine Si Lun, Wang, Michael, Smith, Stephen Douglas, Ladetto, Marco, Huang, Huiqiang, Elstrom, Rebecca L., Co, Melannie, Holmgren, Eric, Huang, Jane, Le Gouill, Steven

“…Abstract only TPS8071 Background: Bruton tyrosine kinase (BTK) mediates B-cell proliferation, migration, and adhesion. BTK inhibition has emerged as a strategy…”
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