Search Results - "Elston, RC"

Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4) with nicotine dependence by Li, Ming D, Beuten, Joke, Ma, Jennie Z, Payne, Thomas J, Lou, Xiang-Yang, Garcia, Veronica, Duenes, Aristeo S, Crews, Karen M, Elston, Robert C

“…We tested six single nucleotide polymorphisms (SNPs) in the alpha 4 subunit gene (CHRNA4) and four SNPs in the beta 2 subunit gene (CHRNB2) of nicotinic…”
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A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies by Song, Kijoung, Elston, Robert C.

“…We present a new method for fine‐mapping a disease susceptibility locus using a case‐control design. The new method, termed the ‘weighted average (WA)…”
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Premature Myocardial Infarction Novel Susceptibility Locus on Chromosome 1P34-36 Identified by Genomewide Linkage Analysis by Wang, Qing, Rao, Shaoqi, Shen, Gong-Qing, Li, Lin, Moliterno, David J., Newby, L. Kristin, Rogers, William J., Cannata, Ruth, Zirzow, Erich, Elston, Robert C., Topol, Eric J.

“…The most frequent causes of death and disability in the Western world are atherosclerotic coronary artery disease (CAD) and acute myocardial infarction (MI)…”
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Whole Genome Scan for Obstructive Sleep Apnea and Obesity in African-American Families by Palmer, Lyle J, Buxbaum, Sarah G, Larkin, Emma K, Patel, Sanjay R, Elston, Robert C, Tishler, Peter V, Redline, Susan

“…Obstructive sleep apnea (OSA) is a common, chronic disease associated with obesity. OSA and obesity are both prevalent in African Americans, who are also at…”
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Self-Reported Race and Genetic Admixture by Sinha, Moumita, Larkin, Emma K, Elston, Robert C, Redline, Susan

“…To the Editor: The use of data on self-reported race in health research has been highly debated. 1 , 2 For example, Burchard et al. recently argued that…”
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Dissection of Genomewide-Scan Data in Extended Families Reveals a Major Locus and Oligogenic Susceptibility for Age-Related Macular Degeneration by Iyengar, Sudha K., Song, Danhong, Klein, Barbara E.K., Klein, Ronald, Schick, James H., Humphrey, Jennifer, Millard, Christopher, Liptak, Rachel, Russo, Karlie, Jun, Gyungah, Lee, Kristine E., Fijal, Bonnie, Elston, Robert C.

“…To examine the genetic basis of age-related macular degeneration (ARMD), a degenerative disease of the retinal pigment epithelium and neurosensory retina, we…”
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A Whole-Genome Scan for Obstructive Sleep Apnea and Obesity by Palmer, Lyle J., Buxbaum, Sarah G., Larkin, Emma, Patel, Sanjay R., Elston, Robert C., Tishler, Peter V., Redline, Susan

“…Obstructive sleep apnea (OSA) is a common, chronic, complex disease associated with serious cardiovascular and neuropsychological sequelae and with substantial…”
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Linkage and Association Analysis of Angiotensin I–Converting Enzyme (ACE)–Gene Polymorphisms with ACE Concentration and Blood Pressure by Zhu, Xiaofeng, Bouzekri, Nourdine, Southam, Lorraine, Cooper, Richard S., Adeyemo, Adebowale, McKenzie, Colin A., Luke, Amy, Chen, Guangjie, Elston, Robert C., Ward, Ryk

“…Considerable effort has been expended to determine whether the gene for angiotensin I–converting enzyme (ACE) confers susceptibility to cardiovascular disease…”
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Linkage Analysis of a Complex Disease through Use of Admixed Populations by Zhu, Xiaofeng, Cooper, Richard S., Elston, Robert C.

“…Linkage disequilibrium arising from the recent admixture of genetically distinct populations can be potentially useful in mapping genes for complex diseases…”
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Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus by Kaabi, Belhassen, Gelernter, Joel, Woods, Scott W., Goddard, Andrew, Page, Grier P., Elston, Robert C.

“…We conducted a 10-centimorgan linkage autosomal genome scan in a set of 19 extended American pedigrees (219 subjects) ascertained through probands with panic…”
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Higher Offspring Survival among Tibetan Women with High Oxygen Saturation Genotypes Residing at 4,000 m by Beall, Cynthia M., Song, Kijoung, Elston, Robert C., Goldstein, Melvyn C.

“…Here we test the hypothesis that high-altitude native resident Tibetan women with genotypes for high oxygen saturation of hemoglobin, and thus less…”
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Optimal two-stage genotyping in population-based association studies by Satagopan, Jaya M., Elston, Robert C.

“…We propose a cost‐effective two‐stage approach to investigate gene‐disease associations when testing a large number of candidate markers using a case‐control…”
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A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus by Zabetian, Cyrus P., Anderson, George M., Buxbaum, Sarah G., Elston, Robert C., Ichinose, Hiroshi, Nagatsu, Toshiharu, Kim, Kwang-Soo, Kim, Chun-Hyung, Malison, Robert T., Gelernter, Joel, Cubells, Joseph F.

“…Dopamine-β-hydroxylase (DβH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Plasma-DβH…”
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Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence by Beuten, Joke, Ma, Jennie Z, Payne, Thomas J, Dupont, Randolph T, Crews, Karen M, Somes, Grant, Williams, Nancy J, Elston, Robert C, Li, Ming D

“…Twelve single-nucleotide polymorphisms (SNPs) in the human gamma-aminobutyric acid type B (GABA(B)) receptor subunit 2 gene (GABAB2) were tested for…”
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High Heritability of Ambulatory Blood Pressure in Families of East African Descent by Bochud, Murielle, Bovet, Pascal, Elston, Robert C, Paccaud, Fred, Falconnet, Catherine, Maillard, Marc, Shamlaye, Conrad, Burnier, Michel

“…We estimated the heritability of ambulatory systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP) in east African families…”
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Testing for Hardy-Weinberg Equilibrium in Small Samples by Elston, R. C., Forthofer, R.

“…An investigation is made of the validity of several statistics to test whether a small sample comes from a population having the binomial proportions p$^2$AA,…”
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GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients : Absence of protease resistance at 48 weeks by MACMANUS, Sarah, YATES, Phillip J, ELSTON, Robert C, WHITE, Susan, RICHARDS, Naomi, SNOWDEN, Wendy

“…To investigate the emergence of resistance to GW433908 (908), a protease inhibitor (PI) with demonstrated antiviral efficacy, safety and tolerability, when…”
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Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence by Ma, Jennie Z., Beuten, Joke, Payne, Thomas J., Dupont, Randolph T., Elston, Robert C., Li, Ming D.

“…DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Because the…”
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On Estimating the Heterozygosity and Polymorphism Information Content Value by Shete, Sanjay, Tiwari, Hemant, Elston, Robert C.

“…The polymorphism information content (PIC) value is commonly used in genetics as a measure of polymorphism for a marker locus used in linkage analysis. In this…”
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Pleiotropic Effects of a Chromosome 3 Locus on Speech-Sound Disorder and Reading by Stein, Catherine M., Schick, James H., Gerry Taylor, H., Shriberg, Lawrence D., Millard, Christopher, Kundtz-Kluge, Amy, Russo, Karlie, Minich, Nori, Hansen, Amy, Freebairn, Lisa A., Elston, Robert C., Lewis, Barbara A., Iyengar, Sudha K.

“…Speech-sound disorder (SSD) is a complex behavioral disorder characterized by speech-sound production errors associated with deficits in articulation,…”
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