Search Results - "Elston, R. C"

Finding genes underlying human disease by Stein, CM, Elston, RC

“…With the surge in genome‐wide association studies (GWAS), many have asked the question ‘Are linkage studies dead?’ In this article, we survey the approaches…”
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Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample by Li, M D, Ma, J Z, Payne, T J, Lou, X-Y, Zhang, D, Dupont, R T, Elston, R C

“…Previously, we reported a genome-wide scan for nicotine dependence (ND) in the African American (AA) sample of the Mid-South Tobacco Family (MSTF) cohort. In…”
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meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference by Heo, M, Leibel, R.L, Fontaine, K.R, Boyer, B.B, Chung, W.K, Koulu, M, Karvonen, M.K, Pesonen, U, Rissanen, A, Laakso, M, Uusitupa, M.I.J, Chagnon, Y, Bouchard, C, Donohoue, P.A, Burns, T.L, Shuldiner, A.R

“…Methods: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K109R, Q223R and K656N) of…”
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In Vitro Development of Resistance to Human Immunodeficiency Virus Protease Inhibitor GW640385 by Yates, P J, Hazen, R, St Clair, M, Boone, L, Tisdale, M, Elston, R C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Haseman and Elston revisited by Elston, Robert C., Buxbaum, Sarah, Jacobs, Kevin B., Olson, Jane M.

“…Haseman and Elston (H‐E) [1972] proposed a method to detect quantitative trait loci by linkage to a marker. The squared sib‐pair trait difference is regressed…”
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Genome-wide search for sarcoidosis susceptibility genes in African Americans by Iannuzzi, M C, Iyengar, S K, Gray-McGuire, C, Elston, R C, Baughman, R P, Donohue, J F, Hirst, K, Judson, M A, Kavuru, M S, Maliarik, M J, Moller, D R, Newman, L S, Rabin, D L, Rose, C S, Rossman, M D, Teirstein, A S, Rybicki, B A

“…Sarcoidosis, a systemic granulomatous disease of unknown etiology, likely results from an environmental insult in a genetically susceptible host. In the US,…”
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The HIV-1 protease substitution K55R: a protease-inhibitor-associated substitution involved in restoring viral replication by Margerison, E. S., Maguire, M., Pillay, D., Cane, P., Elston, R. C.

“…Objectives The identification and in vitro characterization of novel protease mutations strongly associated with known protease resistance mutations. Methods…”
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Lifetime prevalence of uveal melanoma in white patients with oculo(dermal) melanocytosis by Singh, A D, De Potter, P, Fijal, B A, Shields, C L, Shields, J A, Elston, R C

“…In the white population, an association between oculo(dermal) melanocytosis (ODM) and uveal melanoma is well recognized. However, the lifetime prevalence of…”
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Pooling Analysis of Genetic Data: The Association of Leptin Receptor (LEPR) Polymorphisms With Variables Related to Human Adiposity by Heo, M, Leibel, R. L, Boyer, B. B, Chung, W. K, Koulu, M, Karvonen, M. K, Pesonen, U, Rissanen, A, Laakso, M, Uusitupa, M. I. J, Chagnon, Y, Bouchard, C, Donohoue, P. A, Burns, T. L, Shuldiner, A. R, Silver, K, Andersen, R. E, Pedersen, O, Echwald, S, Sorensen, T. I. A, Behn, P, Permutt, M. A, Jacobs, K. B, Elston, R. C, Hoffman, D. J, Allison, D. B

“…Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than…”
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Genomewide Scan for Prostate Cancer–Aggressiveness Loci by Witte, John S., Goddard, Katrina A.B., Conti, David V., Elston, Robert C., Lin, Jennifer, Suarez, Brian K., Broman, Karl W., Burmester, James K., Weber, James L., Catalona, William J.

“…The aggressiveness of prostate cancer (PCa) varies widely: some tumors progress to invasive, potentially life-threatening disease, whereas others stay latent…”
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Using Linkage Analysis to Identify Quantitative Trait Loci for Sleep Apnea in Relationship to Body Mass Index by Larkin, E. K., Patel, S. R., Elston, R. C., Gray‐McGuire, C., Zhu, X., Redline, S.

“…Summary To understand the genetics of sleep apnea, we evaluated the relationship between the apnea hypopnea index (AHI) and body mass index (BMI) through…”
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A Genome Screen of Multiplex Sibships with Prostate Cancer by Suarez, Brian K., Lin, Jennifer, Burmester, James K., Broman, Karl W., Weber, James L., Banerjee, Tarit K., Goddard, Katrina A.B., Witte, John S., Elston, Robert C., Catalona, William J.

“…Analysis of a genome screen of 504 brothers with prostate cancer (CaP) who were from 230 multiplex sibships identified five regions with nominally positive…”
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Multilocus Linkage Tests Based on Affected Relative Pairs by Cordell, Heather J., Wedig, Geoffrey C., Jacobs, Kevin B., Elston, Robert C.

“…For complex diseases, recent interest has focused on methods that take into account joint effects at interacting loci. Conditioning on effects of disease loci…”
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Linkage of serum leptin levels in families with sleep apnea by LARKIN, E. K, ELSTON, R. C, PATEL, S. R, TISHLER, P. V, PALMER, L. J, JENNY, N. S, REDLINE, S

“…To identify regions on the genome linked to plasma leptin levels. Full genome scan with 402 microsatellite markers, spaced approximately 10 cM apart. Data were…”
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A Test of Transmission/Disequilibrium for Quantitative Traits in Pedigree Data, by Multiple Regression by George, Varghese, Tiwari, Hemant K., Zhu, Xiaofeng, Elston, Robert C.

“…The transmission/disequilibrium (TD) test (TDT), proposed, by Spielman et al., for binary traits is a powerful method for detection of linkage between a marker…”
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An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland by McCombs, Candace C, Stevens, Fiona M, McCarthy, Ciaran F, Olson, Jane M, Zhong, Fei, Michalski, Joseph P, Elston, Robert C

“…Celiac disease is a strongly heritable gastrointestinal illness that is an especially important model of the genetically complex multifactorial immune mediated…”
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Linkage information content of polymorphic genetic markers by Guo, X, Elston, R C

“…The Polymorphism Information Content (PIC) value is often used to measure the informativeness of a genetic marker for linkage studies. The PIC value was first…”
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Linkage and association by Elston, Robert C.

“…Methods of both linkage analysis and association analysis may be model‐based or model‐free. The former are useful for initial exploratory analysis, the latter…”
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Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder by Ginns, E I, Galdzicka, M, Elston, R C, Song, Y E, Paul, S M, Egeland, J A

“…Ellis-van Creveld syndrome, an autosomal recessively inherited chondrodysplastic dwarfism, is frequent among Old Order Amish of Pennsylvania. Decades of…”
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Evidence for mendelian inheritance in the pathogenesis of lung cancer by Sellers, T A, Bailey-Wilson, J E, Elston, R C, Wilson, A F, Elston, G Z, Ooi, W L, Rothschild, H

“…Segregation analyses that allowed for variable age of onset of lung cancer and smoking history were performed on 337 families, each ascertained through a lung…”
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