Search Results - "Elson, C O"

Adaptive immunity in the host-microbiota dialog by Feng, T, Elson, C O

“…The intestinal tract represents the largest mucosal surface and is a major site of multifaceted interactions between the host mucosal immune system and…”
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Intestinal IgA: novel views on its function in the defence of the largest mucosal surface by MESTECKY, J, RUSSELL, M W, ELSON, C O

“…In these circumstances, measures designed to enhance the IgA component of the immune response could have an ameliorating effect. [...]a picture is beginning to…”
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Anti–Interleukin-12 Antibody for Active Crohn's Disease by Mannon, Peter J, Fuss, Ivan J, Mayer, Lloyd, Elson, Charles O, Sandborn, William J, Present, Daniel, Dolin, Ben, Goodman, Nancy, Groden, Catherine, Hornung, Ronald L, Quezado, Martha, Neurath, Markus F, Salfeld, Jochen, Veldman, Geertruida M, Schwertschlag, Ullrich, Strober, Warren

“…The cytokine interleukin-12 has been implicated in the intestinal inflammation of Crohn's disease. In this phase 2 trial, the rates of adverse events were…”
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Multiple doses of intravenous Interleukin 10 in steroid-refractory Crohn's disease by VAN DEVENTER, S. J. H, ELSON, C. O, FEDORAK, R. N

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Interleukin (IL)-21 promotes intestinal IgA response to microbiota by Cao, A T, Yao, S, Gong, B, Nurieva, R I, Elson, C O, Cong, Y

“…Commensal microbiota-specific T helper type 17 (Th17) cells are enriched in the intestines, which can convert into T follicular helper (Tfh) in Peyer’s…”
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Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice by Dieleman, L A, Ridwan, B U, Tennyson, G S, Beagley, K W, Bucy, R P, Elson, C O

“…Oral administration of dextran sulfate sodium (DSS) has been reported to induce colitis in mice. The purpose of this study was to determine whether the…”
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A randomized, double‐blind, placebo‐controlled trial of CDP571, a humanized monoclonal antibody to tumour necrosis factor‐α, in patients with corticosteroid‐dependent Crohn's disease by Feagan, B. G., Sandborn, W. J., Baker, J. P., Cominelli, F., Sutherland, L. R., Elson, C. O., Salzberg, B. A., Archambault, A., Bernstein, C. N., Lichtenstein, G. R., Heath, P. K., Cameron, S., Hanauer, S. B.

“…Summary Aim : To evaluate CDP571, a humanized monoclonal antibody to tumour necrosis factor‐α, for the treatment of corticosteroid‐dependent Crohn's disease…”
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Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant by JACKSON, R. J, FUJIHASHI, K, JIANGCHUN XU-AMANO, KIYONO, H, ELSON, C. O, MCGHEE, J. R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding by Husby, S, Mestecky, J, Moldoveanu, Z, Holland, S, Elson, CO

“…The purpose of this study was to investigate whether oral tolerance, defined as Ag-specific immunologic unresponsiveness after Ag feeding, could be induced in…”
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The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective up-regulation of B7.2 expression by Cong, Y, Weaver, CT, Elson, CO

“…Cholera toxin (CT) is a potent mucosal immunogen and adjuvant that can strongly prime mucosal T cells. The present study was undertaken to investigate the…”
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Commensal bacteria as targets in Crohn's disease by Elson, Charles O.

“…GASTROENTEROLOGY 2000;119:254-257…”
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Expanded TCRβ CDR3 clonotypes distinguish Crohn’s disease and ulcerative colitis patients by Wu, J., Pendegraft, A. H., Byrne-Steele, M., Yang, Q., Wang, C., Pan, W., Lucious, T., Seay, T., Cui, X., Elson, C. O., Han, J., Mannon, P. J.

“…We aimed to determine whether the TCR repertoires of Crohn’s disease (CD) patients contain highly prevalent disease-specific T-cell clonotypes reflective of…”
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pANCA represents a cross-reactivity to enteric bacterial antigens by SEIBOLD, F, BRANDWEIN, S, SIMPSON, S, TERHORST, C, ELSON, C. O

“…pANCA (perinuclear antineutrophil cytoplasmic antibodies) occur at a high frequency in patients with ulcerative colitis. The purpose of this study was to…”
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Colitis Induced by Enteric Bacterial Antigen-Specific CD4+ T Cells Requires CD40-CD40 Ligand Interactions for a Sustained Increase in Mucosal IL-12 by Cong, Yingzi, Weaver, Casey T, Lazenby, Audrey, Elson, Charles O

“…C3H/HeJBir is a mouse substrain that is highly susceptible to colitis. Their CD4+ T cells react to Ags of the commensal enteric bacteria, and the latter can…”
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Helper T cell subsets for immunoglobulin A responses : oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues by XU-AMANO, J, KIYONO, H, JACKSON, R. J, STAATS, H. F, FUJIHASHI, K, BURROWS, P. D, ELSON, C. O, PILLAI, S, MCGHEE, J. R

“…Antigen-specific B cell responses to mucosally delivered proteins are dependent upon CD4-positive T helper (Th) cells, and the frequency of Th1 and Th2 cell…”
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Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: mode of action and augmenting effect of inflammatory cytokines by MCGEE, D. W, ELSON, C. O, MCGHEE, J. R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice by Sundberg, J P, Elson, C O, Bedigian, H, Birkenmeier, E H

“…C3H/HeJ mice at the Jackson Laboratory have periodically been culled because of the occurrence of soft feces, perianal ulceration, and right-sided colitis. No…”
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Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin by Elson, CO, Ealding, W

“…Cholera toxin (CT) has been found to be an extremely potent immunogen for mucosal IgA responses when administered via the intestine. This study has examined…”
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Early Upregulation of T Cell IL-10 Production Plays an Important Role in Oral Tolerance Induction by CONG, Y, LIU, C, WEAVER, C T, ELSON, C O

“…: Early in oral tolerance induction, IL‐10‐producing CD4+ T cells were increased, and adoptive transfer of IL‐10‐deficient CD4+ T cells failed induction of…”
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Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora by Brandwein, SL, McCabe, RP, Cong, Y, Waites, KB, Ridwan, BU, Dean, PA, Ohkusa, T, Birkenmeier, EH, Sundberg, JP, Elson, CO

“…The idiopathic inflammatory bowel diseases, ulcerative colitis and Crohn's disease, are chronic disorders that appear to arise from an aberrant interaction of…”
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