Search Results - "Elsocht, Mathias"
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Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors
Published in International journal of molecular sciences (10-01-2021)“…Lung cancer is one of the most frequently diagnosed cancers accounting for the highest number of cancer-related deaths in the world. Despite significant…”
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Antimicrobial Activity of a Repurposed Harmine-Derived Compound on Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates
Published in Frontiers in cellular and infection microbiology (24-01-2022)“…The spread of antibiotic resistant bacteria is an important threat for human health. bacteria impose such a major issue, as multidrug- to pandrug-resistant…”
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Propargylamine Amino Acids as Constrained N ε‑Substituted Lysine Mimetics
Published in Organic letters (13-01-2023)“…Herein, alkylated propargylamines are reported as constrained lysine mimetics and constructed in a single step using a copper(I)-catalyzed A3-coupling…”
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Second generation Spautin-1 analogues targeting EGFR-mutant non-small cell lung cancer cells
Published in Bioorganic & medicinal chemistry letters (01-01-2023)“…Treatment of advanced stage epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is often complicated by the occurrence of…”
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