Search Results - "Elsinga, P H"

Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography by Spoelstra, G. B., Blok, S. N., Reali Nazario, L., Noord, L., Fu, Y., Simeth, N. A., IJpma, F. F. A., van Oosten, M., van Dijl, J. M., Feringa, B. L., Szymanski, W., Elsinga, P. H.

“…Introduction Bacterial infections are a major problem in medicine, and the rapid and accurate detection of such infections is essential for optimal patient…”
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Will extended field-of-view PET/CT depopulate the graveyard of failed PET radiopharmaceuticals? by de Vries, E F J, Elsinga, P H, Tsoumpas, C

“…With the rapid emergence of extended Field-of-View PET-cameras several new applications for radiopharmaceuticals become within reach. Main reason is the…”
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Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier by Raaphorst, RM, Windhorst, AD, Elsinga, PH, Colabufo, NA, Lammertsma, AA, Luurtsema, G

“…ABC transporters protect the brain by transporting neurotoxic compounds from the brain back into the blood. P‐glycoprotein (P‐gp) is the most investigated ABC…”
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Fluorine-18 radiopharmaceuticals beyond [18 F]FDG for use in oncology and neurosciences by Coenen, H.H, Elsinga, P.H, Iwata, R, Kilbourn, M.R, Pillai, M.R.A, Rajan, M.G.R, Wagner, H.N, Zaknun, J.J

“…Abstract Positron emission tomography (PET) is a rapidly expanding clinical modality worldwide thanks to the availability of compact medical cyclotrons and…”
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Altered adenosine 2A and dopamine D2 receptor availability in the 6-hydroxydopamine-treated rats with and without levodopa-induced dyskinesia by Zhou, X., Doorduin, J., Elsinga, P.H., Dierckx, R.A.J.O., de Vries, E.F.J., Casteels, C.

“…Several lines of evidence imply alterations in adenosine signaling in Parkinson's disease (PD). Here, we investigated cerebral changes in adenosine 2A receptor…”
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New sensitive method for HEPES quantification in 68Ga-radiopharmaceuticals by Antunes, I. F., Franssen, G. M., Zijlma, R., Laverman, P., Boersma, H. H., Elsinga, P. H.

“…Background The introduction of a GMP-certified 68 Ga-generator spurred the application of 68 Ga-radiopharmaceuticals. Several radiosynthesis of 68…”
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Improved GMP-compliant multi-dose production and quality control of 6-[18F]fluoro-L-DOPA by Luurtsema, G., Boersma, H. H., Schepers, M., de Vries, A. M. T., Maas, B., Zijlma, R., de Vries, E. F. J., Elsinga, P. H.

“…Background 6-[ 18 F]Fluoro-L-3,4-dihydroxyphenylalanine (FDOPA) is a frequently used radiopharmaceutical for detecting neuroendocrine and brain tumors and for…”
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Pharmacological screening identifies SHK242 and SHK277 as novel arginase inhibitors with efficacy against allergen-induced airway narrowing in vitro and in vivo by Van den Berg, Mariska P M, Kurhade, Santosh H, Maarsingh, Harm, Erceg, Stefanie, Hulsbeek, Imke R, Boekema, Pieter H, Kistemaker, Loes E M, van Faassen, Martijn, Kema, Ido P, Elsinga, Philip H, Dömling, Alex S S, Meurs, Herman, Gosens, Reinoud

“…Arginase is a potential target for asthma treatment. However, currently there are no arginase inhibitors available for clinical use. Here a novel class of…”
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Synthesis and evaluation of [18F]fluoroethyl SA4503 as a PET ligand for the sigma receptor by Elsinga, P.H., Kawamura, K., Kobayashi, T., Tsukada, H., Senda, M., Vaalburg, W., Ishiwata, K.

“…The sigma receptor might be involved in several diseases in the central nervous system. It occurs in the endocrine, immune, and other peripheral organ systems…”
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P-glycoprotein activity and biological response by Vaalburg, W., Hendrikse, N.H., Elsinga, P.H., Bart, J., van Waarde, A.

“…P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most likely P-gp protects organs against endogenous and…”
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Adenosine A(1) receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging by Paul, S, Elsinga, P H, Ishiwata, K, Dierckx, R A J O, van Waarde, A

“…Adenosine is a neuromodulator with several functions in the central nervous system (CNS), such as inhibition of neuronal activity in many signaling pathways…”
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Synthesis and evaluation of radiolabeled antagonists for imaging of β-adrenoceptors in the brain with PET by Doze, P, Elsinga, P.H, Maas, B, Van Waarde, A, Wegman, T, Vaalburg, W

“…Five potent, lipophilic β-adrenoceptor antagonists (carvedilol, pindolol, toliprolol and fluorinated analogs of bupranolol and penbutolol) were labeled with…”
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Adenosine A(2A) receptor antagonists as Positron Emission Tomography (PET) tracers by Khanapur, S, Waarde, A van, Ishiwata, K, Leenders, K L, Dierckx, R A J O, Elsinga, P H

“…The adenosine A(2A) receptor (A(2A)R) is highly concentrated in the striatum, and a therapeutic target for Parkinson's disorder (PD) and Huntington's disease…”
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GRPR-selective PET imaging of prostate cancer using [18F]-lanthionine-bombesin analogs by Carlucci, G., Kuipers, A., Ananias, H.J.K., de Paula Faria, D., Dierckx, R.A.J.O., Helfrich, W., Rink, R., Moll, G.N., de Jong, I.J., Elsinga, P.H.

“…•The GRP receptor is overexpressed in several human cancer, including prostate cancer.•Full-length lanthionine-BBN analogs were used as PET agents for GRPR…”
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An improved method for the preparation of [ 11C]verapamil by Wegman, T.D., Maas, B., Elsinga, P.H., Vaalburg, W.

“…This paper describes an improved preparation of [ 11C]verapamil by reaction of [ 11C]methyl triflate with desmethylverapamil. The optimal reaction temperature,…”
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Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier by Doze, P., Van Waarde, A., Elsinga, P.H., Hendrikse, N.H., Vaalburg, W.

“…Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P‐glycoprotein (P‐gp), an ATP‐driven drug efflux pump at the blood–brain barrier…”
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Synthesis and evaluation of ( S)- [formula omitted]-fluoroethylcarazolol for in vivo β-adrenoceptor imaging in the brain by Doze, P., van Waarde, A., Tewson, T.J., Vaalburg, W., Elsinga, P.H.

“…The β-adrenergic receptor ligand ( S)-4-(3-(2′- [ 18 F] -fluoroethylamino)-2-hydroxypropoxy)-carbazol (( S)- [ 18 F] -fluoroethylcarazolol) was prepared by…”
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New diagnostic techniques in staging in the surgical treatment of cutaneous malignant melanoma by Cobben, D.C.P., Koopal, S., Tiebosch, A.T.M.G., Jager, P.L., Elsinga, P.H., Wobbes, Th, Hoekstra, H.J.

“…The emphasis of the research on the surgical treatment of melanoma has been on the resection margins, the role of elective lymph node dissection in high risk…”
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Nuclear imaging of prostate cancer with gastrin-releasing-peptide-receptor targeted radiopharmaceuticals by Ananias, H J K, de Jong, I J, Dierckx, R A, van de Wiele, C, Helfrich, W, Elsinga, P H

“…Prostate cancer is one of the most common causes of cancer in men. Evaluating the different stages of prostate cancer with conventional imaging techniques…”
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Development of a reliable remote-controlled synthesis of β-[11C]-5-hydroxy-L-tryptophan on a Zymark robotic system by Neels, O. C., Jager, P. L., Koopmans, K. P., Eriks, E., de Vries, E. G. E., Kema, I. P., Elsinga, P. H.

“…Precise staging of neuroendocrine tumors (NET) using positron emission tomography (PET) tracers visualizing their specific metabolic activity is of interest…”
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