Search Results - "Elsinga, P"

Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography by Spoelstra, G. B., Blok, S. N., Reali Nazario, L., Noord, L., Fu, Y., Simeth, N. A., IJpma, F. F. A., van Oosten, M., van Dijl, J. M., Feringa, B. L., Szymanski, W., Elsinga, P. H.

“…Introduction Bacterial infections are a major problem in medicine, and the rapid and accurate detection of such infections is essential for optimal patient…”
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Will extended field-of-view PET/CT depopulate the graveyard of failed PET radiopharmaceuticals? by de Vries, E F J, Elsinga, P H, Tsoumpas, C

“…With the rapid emergence of extended Field-of-View PET-cameras several new applications for radiopharmaceuticals become within reach. Main reason is the…”
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Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier by Raaphorst, RM, Windhorst, AD, Elsinga, PH, Colabufo, NA, Lammertsma, AA, Luurtsema, G

“…ABC transporters protect the brain by transporting neurotoxic compounds from the brain back into the blood. P‐glycoprotein (P‐gp) is the most investigated ABC…”
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Fluorine-18 radiopharmaceuticals beyond [18 F]FDG for use in oncology and neurosciences by Coenen, H.H, Elsinga, P.H, Iwata, R, Kilbourn, M.R, Pillai, M.R.A, Rajan, M.G.R, Wagner, H.N, Zaknun, J.J

“…Abstract Positron emission tomography (PET) is a rapidly expanding clinical modality worldwide thanks to the availability of compact medical cyclotrons and…”
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C-Choline Positron Emission Tomography for the Evaluation after Treatment of Localized Prostate Cancer by DEJONG, I, PRUIM, J, ELSINGA, P, VAALBURG, W, MENSINK, H

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Altered adenosine 2A and dopamine D2 receptor availability in the 6-hydroxydopamine-treated rats with and without levodopa-induced dyskinesia by Zhou, X., Doorduin, J., Elsinga, P.H., Dierckx, R.A.J.O., de Vries, E.F.J., Casteels, C.

“…Several lines of evidence imply alterations in adenosine signaling in Parkinson's disease (PD). Here, we investigated cerebral changes in adenosine 2A receptor…”
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Pharmacological screening identifies SHK242 and SHK277 as novel arginase inhibitors with efficacy against allergen-induced airway narrowing in vitro and in vivo by Van den Berg, Mariska P M, Kurhade, Santosh H, Maarsingh, Harm, Erceg, Stefanie, Hulsbeek, Imke R, Boekema, Pieter H, Kistemaker, Loes E M, van Faassen, Martijn, Kema, Ido P, Elsinga, Philip H, Dömling, Alex S S, Meurs, Herman, Gosens, Reinoud

“…Arginase is a potential target for asthma treatment. However, currently there are no arginase inhibitors available for clinical use. Here a novel class of…”
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Nuclear imaging of prostate cancer with gastrin-releasing-peptide-receptor targeted radiopharmaceuticals by Ananias, H J K, de Jong, I J, Dierckx, R A, van de Wiele, C, Helfrich, W, Elsinga, P H

“…Prostate cancer is one of the most common causes of cancer in men. Evaluating the different stages of prostate cancer with conventional imaging techniques…”
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Guidance on validation and qualification of processes and operations involving radiopharmaceuticals by Todde, S., Peitl, P. Kolenc, Elsinga, P., Koziorowski, J., Ferrari, V., Ocak, E. M., Hjelstuen, O., Patt, M., Mindt, T. L., Behe, M.

“…Background Validation and qualification activities are nowadays an integral part of the day by day routine work in a radiopharmacy. This document is meant as…”
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Adenosine A(1) receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging by Paul, S, Elsinga, P H, Ishiwata, K, Dierckx, R A J O, van Waarde, A

“…Adenosine is a neuromodulator with several functions in the central nervous system (CNS), such as inhibition of neuronal activity in many signaling pathways…”
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Adenosine A(2A) receptor antagonists as Positron Emission Tomography (PET) tracers by Khanapur, S, Waarde, A van, Ishiwata, K, Leenders, K L, Dierckx, R A J O, Elsinga, P H

“…The adenosine A(2A) receptor (A(2A)R) is highly concentrated in the striatum, and a therapeutic target for Parkinson's disorder (PD) and Huntington's disease…”
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Radiopharmaceuticals are special, but is this recognized? The possible impact of the new Clinical Trials Regulation on the preparation of radiopharmaceuticals by Decristoforo, C., Penuelas, I., Elsinga, P., Ballinger, J., Winhorst, A. D., Verbruggen, A., Verzijlbergen, F., Chiti, A.

“…Nuclear medicine techniques are in the forefront of molecular imaging, thereby translating discoveries in molecular biology, genetics, pharmacology and many…”
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GRPR-selective PET imaging of prostate cancer using [18F]-lanthionine-bombesin analogs by Carlucci, G., Kuipers, A., Ananias, H.J.K., de Paula Faria, D., Dierckx, R.A.J.O., Helfrich, W., Rink, R., Moll, G.N., de Jong, I.J., Elsinga, P.H.

“…•The GRP receptor is overexpressed in several human cancer, including prostate cancer.•Full-length lanthionine-BBN analogs were used as PET agents for GRPR…”
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Position paper on requirements for toxicological studies in the specific case of radiopharmaceuticals by Koziorowski, J., Behe, M., Decristoforo, C., Ballinger, J., Elsinga, P., Ferrari, V., Kolenc Peitl, P., Todde, S., Mindt, T. L.

“…This is a position paper of the Radiopharmacy Committee of the EANM (European Association of Nuclear Medicine) addressing toxicology studies for application of…”
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New sensitive method for HEPES quantification in 68Ga-radiopharmaceuticals by Antunes, I. F., Franssen, G. M., Zijlma, R., Laverman, P., Boersma, H. H., Elsinga, P. H.

“…Background The introduction of a GMP-certified 68 Ga-generator spurred the application of 68 Ga-radiopharmaceuticals. Several radiosynthesis of 68…”
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P-glycoprotein activity and biological response by Vaalburg, W., Hendrikse, N.H., Elsinga, P.H., Bart, J., van Waarde, A.

“…P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most likely P-gp protects organs against endogenous and…”
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Improved GMP-compliant multi-dose production and quality control of 6-[18F]fluoro-L-DOPA by Luurtsema, G., Boersma, H. H., Schepers, M., de Vries, A. M. T., Maas, B., Zijlma, R., de Vries, E. F. J., Elsinga, P. H.

“…Background 6-[ 18 F]Fluoro-L-3,4-dihydroxyphenylalanine (FDOPA) is a frequently used radiopharmaceutical for detecting neuroendocrine and brain tumors and for…”
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Preclinical Evaluation of a Novel 111In-Labeled Bombesin Homodimer for Improved Imaging of GRPR-Positive Prostate Cancer by Carlucci, G, Ananias, H. J. K, Yu, Z, Hoving, H. D, Helfrich, W, Dierckx, R. A. J. O, Liu, S, de Jong, I. J, Elsinga, P. H

“…Rational-designed multimerization of targeting ligands can be used to improve kinetic and thermodynamic properties. Multimeric targeting ligands may be…”
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Synthesis and evaluation of [18F]fluoroethyl SA4503 as a PET ligand for the sigma receptor by Elsinga, P.H., Kawamura, K., Kobayashi, T., Tsukada, H., Senda, M., Vaalburg, W., Ishiwata, K.

“…The sigma receptor might be involved in several diseases in the central nervous system. It occurs in the endocrine, immune, and other peripheral organ systems…”
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The specific case of radiopharmaceuticals and GMP—activities of the Radiopharmacy Committee by Decristoforo, C., Elsinga, P., Faivre-Chauvet, A., Farstad, B., Meyer, G., Mikolajczak, R., Penuelas, I., Unak, P., Westera, G.

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