Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems

The oral route of administration is considered the easiest, most convenient and widely used drug delivery route. One of the hardest challenges facing oral drug delivery systems (DDS) is the erratic absorption of drugs through the gastrointestinal tract (GIT). The conventional oral dosage forms usual...

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Bibliographic Details
Published in:	Archives of Pharmaceutical Sciences Ain Shams University Vol. 6; no. 2; pp. 221 - 238
Main Authors:	Elsherbeeny, walaa, El-Gogary, Riham, Nasr, Maha, Sammour, Omaima
Format:	Journal Article
Language:	English
Published:	Ain Shams University 01-12-2022
Subjects:	controlled release gastroretentive delivery systems narrow absorption window oral route tablets
Online Access:	Get full text
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Summary:	The oral route of administration is considered the easiest, most convenient and widely used drug delivery route. One of the hardest challenges facing oral drug delivery systems (DDS) is the erratic absorption of drugs through the gastrointestinal tract (GIT). The conventional oral dosage forms usually suffer from low bioavailability especially in case of drugs with narrow absorption window (NAW). The oral controlled release dosage forms could overcome the previous limitation by providing predicted and calculated drug release, resulting in improvement of the efficacy of drugs. One of the most promising types of oral controlled release dosage forms for this purpose is the gastro retentive drug delivery system (GRDDS), which was found to improve the gastric retention of the dosage form and maximize the absorption and bioavailability of the drugs with NAW. In this review, we summarize the different GRDDS techniques used for improving drug absorption, their methods of preparation, and their mechanisms of action.
ISSN:	2356-8399 2356-8380 2356-8399
DOI:	10.21608/aps.2022.168128.1101