Search Results - "Elshemy, Heba A. H"

New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling by Abdelgawad, Mohamed A, Bukhari, Syed N. A, Musa, Arafa, Elmowafy, Mohammed, Elkomy, Mohammed H, Nayl, AbdElAziz. A, El-Ghorab, Ahmed H, Alsohaimi, Ibrahim Hotan, Abdel-Bakky, Mohamed Sadek, Althobaiti, Ibrahim O, Altaleb, Hamud A, Omar, Hany A, Abdelazeem, Ahmed H, Zaki, Mohamed A, Shaker, Mohamed E, Elshemy, Heba A. H

“…In this study new sulphamethoxazole derivatives (S1–S4, S6–S12, and S14–S22) were designed and synthesized and their structures were fully characterized and…”
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Synthesis and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing an aminosulphonyl pharmacophore by Abdellatif, Khaled R. A, Abdelgawad, Mohamed A, Elshemy, Heba A. H, Alsayed, Shahinda S. R, Kamel, Gehan

“…A novel series of 2-pyrazoline derivatives 13a–l was synthesized via aldol condensation of 4-substituted acetophenones with appropriately substituted aldehydes…”
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Characterization of novel heterocyclic compounds based on 4-aryl-4H-chromene scaffold as anticancer agents: Design, synthesis, antiprofilerative activity against resistant cancer cells, dual β-tubulin/c-Src inhibition, cell cycle arrest and apoptosis induction by Abdelall, Eman K.A., A. H. Elshemy, Heba, Labib, Madlen B., E. A. Mohamed, Fatma

“…[Display omitted] •Novel sets of 4-aryl-4H-chromene derivatives were synthesized.•Target compounds were screened for their antiproliferative activity against…”
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Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methods by Abdelwahab, Nada S., Elshemy, Heba A. H., Farid, Nehal F.

“…Flutamide is a potential antineoplastic drug classified as an anti-androgen. It is a therapy for men with advanced prostate cancer, administered orally after…”
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New indomethacin analogs as selective COX‐2 inhibitors: Synthesis, COX‐1/2 inhibitory activity, anti‐inflammatory, ulcerogenicity, histopathological, and docking studies by Abdellatif, Khaled R. A., Abdelall, Eman K. A., Elshemy, Heba A. H., El‐Nahass, El‐Shaymaa, Abdel‐Fattah, Maha M., Abdelgawad, Yasmin Y. M.

“…New indomethacin analogs 4a–g, 5, 6, 8a, and 8b were synthesized to overcome the nonselectivity and ulcer liability of indomethacin. All newly synthesized…”
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Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile by Abdellatif, Khaled R.A., Abdelgawad, Mohamed A., Elshemy, Heba A.H., Alsayed, Shahinda S.R.

“…[Display omitted] •Two groups of thiazolidin-4-ones 4a–c and 8a–e were designed and synthesized.•Compounds 8c and 8d showed the best overall in vitro COX-2…”
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New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation by Abdelgawad, Mohamed A., Al-Sanea, Mohammad M., Zaki, Mohamed A., Mohamed, Enas I. A., Khan, Shabana I., Tekwani, Babu L., Chittiboyina, Amar G, Khan, Ikhlas A, Al-Warhi, Tarfah, Aljaeed, Nada, Alotaibi, Ohoud J., Alkhaldi, Abdulsalam A. M., Elshemy, Heba A. H.

“…Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial…”
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Design and synthesis of new coumarin hybrids and insight into their mode of antiproliferative action by Elshemy, Heba A.H., Zaki, Mohamed A.

“…[Display omitted] Molecular hybridization approach was used to synthesize three series of coumarin based hybrids by conglomerate a substituted chalcones,…”
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New pyrimidine-benzoxazole/benzimidazole hybrids: Synthesis, antioxidant, cytotoxic activity, in vitro cyclooxygenase and phospholipase A2-V inhibition by Abdelgawad, Mohamed A., Bakr, Rania B., Ahmad, Waqas, Al-Sanea, Mohammad M., Elshemy, Heba A.H.

“…[Display omitted] •The new intermediates new 6a&b and the target new pyrimidines 7a&b were designed and prepared.•The structure of new targets was proved using…”
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A multicomponent reaction to design antimalarial pyridyl-indole derivatives: Synthesis, biological activities and molecular docking by Elshemy, Heba A.H., Zaki, Mohamed A., Mohamed, Enas I., Khan, Shabana I., Lamie, Phoebe F.

“…[Display omitted] •Twenty five novel pyridyl-indole hybrids 4a–y were synthesized.•Multicomponent one pot reaction condition was used as a synthetic…”
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Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights by Al-Sanea, Mohammad M., Elkamhawy, Ahmed, Paik, Sora, Lee, Kyeong, El Kerdawy, Ahmed M., Syed Nasir Abbas, Bukhari, Joo Roh, Eun, Eldehna, Wagdy M., Elshemy, Heba A.H., Bakr, Rania B, Ali Farahat, Ibrahim, Alzarea, Abdulaziz I., Alzarea, Sami I., Alharbi, Khalid S., Abdelgawad, Mohamed A.

“…Three series of 4-anilinoquinoline derivatives bearing a sulfonamide moiety (5a-d, 9a-d and 11a-d) were designed and synthesized as potential novel dual Aurora…”
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Design, synthesis of novel chromene‐based scaffolds targeting hepatocellular carcinoma: Cell cycle arrest, cytotoxic effect against resistant cancer cells, apoptosis induction, and c‐Src inhibition by Abdelall, Eman K. A., Elshemy, Heba A. H., Labib, Madlen B., Mohamed, Fatma E. A.

“…New chromene derivatives were synthesized based on 4‐(3,4‐dimethoxy)‐4H‐chromene scaffold. All target compounds exhibited cytotoxic activity against HepG2…”
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Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC by Elshemy, Heba A.H., Abdelall, Eman K.A., Azouz, Amany A., Moawad, Abeer, Ali, Waleed A.M., Safwat, Nesreen M.

“…Three novel triazines series were prepared. These series are pyrazolines (4a and 4b), pyrazoles (6a, 6b and 8a-d) and isoxazoles (7a and 7b). Such series were…”
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Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies by Abdellatif, Khaled R.A., Abdelall, Eman K.A., Elshemy, Heba A.H., Philoppes, John N., Hassanein, Emad H.M., Kahk, Nesma M.

“…[Display omitted] •New pyrazole / triazole hybrids 4a,b, 5a,b, 7a,b, 9a,b, 10a-f, and 11a-f were synthesized.•Compounds 4b, 7a, 10e, 11c, and 11e showed good…”
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Antitrypanosomal activity of new semi‐synthetic bergenin derivatives by El‐Hawary, Seham S., Mohammed, Rabab, AbouZid, Sameh, Zaki, Mohamed A., Ali, Zeinab Y., Elwekeel, Ahlam, Elshemy, Heba A. H.

“…Bergenin and 11‐O‐(4'‐O‐methyl galloyl)‐bergenin, previously isolated from Crassula capitella extract, were used as starting materials for the synthesis of…”
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Development of safe and antioxidant COX-2 inhibitors; Synthesis, molecular docking analysis and biological evaluation of novel pyrrolizine 5-carboxamides by K. A. Abdelall, Eman, Elshemy, Heba A.H., Philoppes, John N., Abdel-Fattah, Maha M., El-Nahaas, El-Shaymaa, Mahmoud, Rabab R.

“…[Display omitted] •A series of new pyrrolizine-5-carboxamide derivatives were developed as antioxidant COX-2 Inhibitors.•Compounds 9a, 9b, 9d, and 11b have…”
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Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study by Abdellatif, Khaled R.A., Abdelall, Eman K.A., Elshemy, Heba A.H., Philoppes, John N., Hassanein, Emad H.M., Kahk, Nesma M.

“…[Display omitted] •Four new series of 1,2,4 triazoles were developed as selective COX-2 inhibitors.•Compounds 4a, 5b, 6a, and 7a have higher COX-2 selectivity…”
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Synthesis of novel chromene derivatives of expected antitumor activity by Kandeel, Manal M., Kamal, Aliaa M., Abdelall, Eman K.A., Elshemy, Heba A.H.

“…Inhibition of tubulin polymerization is one of the important tactics in cancer therapy. Since 4-aryl-4H-chromene derivatives are found to be…”
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1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents by Abdellatif, Khaled R.A., Elshemy, Heba A.H., Azoz, Amany A.

“…[Display omitted] •Two groups of 2-pyrazoline and pyrazole derivatives were designed and synthesized.•All the compounds were more selective COX-2 inhibitors…”
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Development of potential anticancer agents and apoptotic inducers based on 4-aryl-4H chromene scaffold: Design, synthesis, biological evaluation and insight on their proliferation inhibition mechanism by Elshemy, Heba A.H., Zaki, Mohamed A., Mahmoud, Ayman M., Khan, Shabana I., Chittiboyina, Amar G., Kamal, Aliaa M.

“…[Display omitted] •New series of potent cytotoxic agents was developed based on 4H chromene scaffold.•In vitro screening of active candidates on NCI panel of…”
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