Schizophrenic patients’ cognitive functions in relation to their metabolic profile: a cross-sectional, comparative study on an Egyptian sample

Schizophrenic patients’ cognitive functions in relation to their metabolic profile: a cross-sectional, comparative study on an Egyptian sample

Background Patients with schizophrenia suffer from diffuse cognitive impairment and high prevalence of cardiovascular metabolic risks, associated with poor clinical outcomes. We aimed in this study to test the presence of cognitive impairment in a sample of patients with schizophrenia, and evaluate...

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Bibliographic Details
Published in:Middle East current psychiatry (Cairo) Vol. 27; no. 1; pp. 1 - 6
Main Authors: Ali, Dalia Hegazy, Elserafi, Doha Mostafa, Soltan, Marwa Abdel Rahman, Eissa, Mohamed Fikry, Zein, Hanan Ahmed, Elshahawi, Heba Hamed
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 20-10-2020
Springer Nature B.V
SpringerOpen
Subjects:
Alzheimer's disease
Body mass index
Cardiovascular disease
Cognitive ability
Cognitive impairment
Comparative studies
Diabetes
Executive function
Hospitals
Hypertension
Medicine
Medicine & Public Health
Memory
Mental health
Metabolic disorders
Metabolic syndrome
Patients
Population
Psychiatry
Schizophrenia
Variance analysis
Vascular risk
Schizophrenia
Metabolic syndrome
Vascular risk
Cognitive impairment
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Summary:Background Patients with schizophrenia suffer from diffuse cognitive impairment and high prevalence of cardiovascular metabolic risks, associated with poor clinical outcomes. We aimed in this study to test the presence of cognitive impairment in a sample of patients with schizophrenia, and evaluate its possible relations to patients’ metabolic profile. We recruited forty patients diagnosed with schizophrenia and their matched controls from the inpatient departments and outpatient services from January to December 2016. Schizophrenia diagnosis was confirmed by the ICD10 criteria checklist. Symptoms profile and severity were assessed by the Positive and Negative Syndrome Scale. Cognitive profile was assessed through (1) Trail Making Test, Parts A and B and (2) Wechsler Memory Scale-Revised Visual Reproduction Test. Metabolic profile was assessed by measuring the body mass index, fasting blood glucose, and lipid profile. SPSS (V. 22.0, IBM Corp., USA, 2013) was used for data analysis. Results The patients group had a significantly higher means in the speed of processing, executive function, attention, and working memory scores on TMT-A ( p = 0.0), TMT-B ( p = 0.00), and WMS-R ( p = 0.029) and significantly higher FBG levels ( p = 0.00). Correlation studies showed that the increase in patients’ age, illness duration, treatments, number of hospitalizations, number of episodes and of ECT sessions received, symptoms severity, and deficits in cognitive function scores was associated with higher BMI and FBG. Conclusions Patients with schizophrenia have a higher prevalence of cognitive impairment and vascular risk factors than the general population. Close monitoring and early management of these risk factors can promote better cognitive abilities and overall functions.
ISSN:2090-5416
2090-5408
2090-5416
DOI:10.1186/s43045-020-00053-w