Search Results - "Elsen, Peter J. van den"

Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance by Vijayan, Saptha, Sidiq, Tabasum, Yousuf, Suhail, van den Elsen, Peter J., Kobayashi, Koichi S.

“…Major histocompatibility complex (MHC) class I and class II molecules play critical roles in the activation of the adaptive immune system by presenting…”
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Expression regulation of major histocompatibility complex class I and class II encoding genes by van den Elsen, Peter J

“…Major histocompatibility complex (MHC)-I and MHC-II molecules play an essential role in the immune response to pathogens by virtue of their ability to present…”
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Preactive multiple sclerosis lesions offer novel clues for neuroprotective therapeutic strategies by van Noort, Johannes M, van den Elsen, Peter J, van Horssen, Jack, Geurts, Jeroen J G, van der Valk, Paul, Amor, Sandra

“…For the development of novel central nervous system (CNS) drugs to promote neuroprotection, it is helpful to gain a betterunderstanding of natural…”
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Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating Leukocytes by van Essen, T Huibertus, van Pelt, Sake I, Bronkhorst, Inge H G, Versluis, Mieke, Némati, Fariba, Laurent, Cécile, Luyten, Gregorius P M, van Hall, Thorbald, van den Elsen, Peter J, van der Velden, Pieter A, Decaudin, Didier, Jager, Martine J

“…Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and increased human leukocyte antigen (HLA) expression, carry an…”
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Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation by van Horssen, Jack, Singh, Shailender, van der Pol, Susanne, Kipp, Markus, Lim, Jamie L, Peferoen, Laura, Gerritsen, Wouter, Kooi, Evert-Jan, Witte, Maarten E, Geurts, Jeroen J G, de Vries, Helga E, Peferoen-Baert, Regina, van den Elsen, Peter J, van der Valk, Paul, Amor, Sandra

“…In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located…”
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NLRC5: a key regulator of MHC class I-dependent immune responses by Kobayashi, Koichi S., van den Elsen, Peter J.

“…The identification of NLRC5 as a transcriptional transactivator of MHC class I genes has shed light on the regulation of MHC class I expression. This Progress…”
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NLR family member NLRC5 is a transcriptional regulator of MHC class I genes by Meissner, Torsten B., Li, Amy, Biswas, Amlan, Lee, Kyoung-Hee, Liu, Yuen-Joyce, Bayir, Erkan, Iliopoulos, Dimitrios, van den Elsen, Peter J., Kobayashi, Koichi S., Strominger, Jack

“…MHC class I plays a critical role in the immune defense against viruses and tumors by presenting antigens to CD8 T cells. An NLR protein, class II…”
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HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients by de Kruijf, Esther M, Sajet, Anita, van Nes, Johanna G H, Natanov, Russ, Putter, Hein, Smit, Vincent T H B M, Liefers, Gerrit Jan, van den Elsen, Peter J, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Nonclassical HLAs, HLA-E and HLA-G, are known to affect clinical outcome in various tumor types. We examined the clinical impact of HLA-E and HLA-G expression…”
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Chemical and genetic control of IFNγ‐induced MHCII expression by Wijdeven, Ruud H, van Luijn, Marvin M, Wierenga‐Wolf, Annet F, Akkermans, Jimmy J, van den Elsen, Peter J, Hintzen, Rogier Q, Neefjes, Jacques

“…The cytokine interferon‐γ (IFNγ) can induce expression of MHC class II (MHCII) on many different cell types, leading to antigen presentation to CD4 + T cells…”
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Epigenetics in atherosclerosis and inflammation by Wierda, Rutger J., Geutskens, Sacha B., Jukema, J. Wouter, Quax, Paul H.A., van den Elsen, Peter J.

“…•  Introduction •  Epigenetics explained ‐  Epigenetic alterations are reversible •  Atherosclerosis •  Epigenetics and association with atherosclerosis • …”
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Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease by Pons, Douwe, de Vries, Florentine R., van den Elsen, Peter J., Heijmans, Bastiaan T., Quax, Paul H.A., Jukema, J. Wouter

“…Significant progress has been made in the clinical management of a variety of cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current…”
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Mutations in ZBTB24 Are Associated with Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome Type 2 by DE GREEF, Jessica C, JUN WANG, GENNERY, Andrew R, GIMELLI, Giorgio, REISLI, Ismail, SCHUETZ, Catharina, SCHULZ, Ansgar, SMEETS, Dominique F. C. M, SZNAJER, Yves, WIJMENGA, Cisca, VAN EGGERMOND, Marja C, VAN OSTAIJEN-TEN DAM, Monique M, BALOG, Judit, LANKESTER, Arjan C, VAN TOL, Maarten J. D, VAN DEN ELSEN, Peter J, WEEMAES, Corry M, VAN DER MAAREL, Silvere M, DEN DUNNEN, Johan T, FRANTS, Rune R, STRAASHEIJM, Kirsten R, AYTEKIN, Caner, VAN DER BURG, Mirjam, DUPREZ, Laurence, FERSTER, Alina

“…Autosomal-recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is mainly characterized by recurrent, often fatal,…”
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The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development by de Jong, Rob C M, Ewing, Mark M, de Vries, Margreet R, Karper, Jacco C, Bastiaansen, Antonius J N M, Peters, Hendrika A B, Baghana, Fabiana, van den Elsen, Peter J, Gongora, Céline, Jukema, J Wouter, Quax, Paul H A

“…Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor…”
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Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells? by Sestito, Claudia, Brevé, John J P, van Eggermond, Marja C J A, Killestein, Joep, Teunissen, Charlotte E, van Rossum, Joram, Wilhelmus, Micha M M, Drukarch, Benjamin, van den Elsen, Peter J, van Dam, Anne-Marie

“…Leukocyte infiltration into the central nervous system is an important feature of multiple sclerosis (MS) pathology. Among the infiltrating cells, monocytes…”
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Oxidative phosphorylation induces de novo expression of the MHC class I in tumor cells through the ERK5 pathway by Charni, Seyma, de Bettignies, Geoffroy, Rathore, Moeez G, Aguiló, Juan I, van den Elsen, Peter J, Haouzi, Delphine, Hipskind, Robert A, Enriquez, José Antonio, Sanchez-Beato, Margarita, Pardo, Julián, Anel, Alberto, Villalba, Martin

“…Most cancer cells use anaerobic-like glycolysis to generate energy instead of oxidative phosphorylation. They also avoid recognition by CTLs, which occurs…”
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Antigen-independent acquisition of MHC class II molecules by human T lymphocytes by Undale, Anita H., van den Elsen, Peter J., Celis, Esteban

“…We report here that human T lymphocytes have the capacity of acquiring large amounts of MHC class II molecules from various types of antigen-presenting cells…”
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Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors by Wierda, Rutger J., Kuipers, Hedwich F., van Eggermond, Marja C. J. A., Benard, Anne, van Leeuwen, Jan C., Carluccio, Silvia, Geutskens, Sacha B., Jukema, J. Wouter, Marquez, Victor E., Quax, Paul H. A., van den Elsen, Peter J.

“…Previously, we have shown that CCR5 transcription is regulated by CREB‐1. However, the ubiquitous pattern of CREB‐1 expression suggests the involvement of an…”
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Simvastatin reduces CCL2 expression in monocyte-derived cells by induction of a repressive CCL2 chromatin state by Zanette, Dalila L, van Eggermond, Marja C.J.A, Haasnoot, Geert, van den Elsen, Peter J

“…Abstract Statins exert anti-inflammatory characteristics, besides their lipid lowering properties, and may display beneficial effects for the treatment of…”
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E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII) by van der Stoep, Nienke, Quinten, Edwin, Rezende, Marisa Marcondes, van den Elsen, Peter J.

“…In B cells, expression of CIITA and resulting major histocompatibility complex II (MHCII) is mediated exclusively by promoter III (CIITA-PIII) activation…”
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Genetic and Epigenetic Regulation of CCR5 Transcription by Wierda, Rutger J, van den Elsen, Peter J

“…The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature…”
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