A Meta-analysis on Vitamin D Deficiency in Patients with Sickle Cell Disease

Vitamin D Deficiency (VDD) is reported to be more frequent with serious clinical outcomes in patients with Sickle Cell Disease (SCD). There is a wide disparity in data in the existing literature regarding the prevalence and risk of VDD in patients with SCD. These data require further summary and ana...

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Bibliographic Details
Published in:	Dr. Sulaiman Al Habib medical journal Vol. 2; no. 3; pp. 95 - 100
Main Authors:	Mohamed, Sagad Omer Obeid, MohamedElmugadam, Fatima Abdelhakam Abdellatif, Awadalla, Hiba Faroug Mohamed, Mohamedali, Abdalla Omer Obeid, Alawad, Mansour Osman Alhaj, Noureddin, Ahmed Abdulgadir, Osman, Afnan Abugundul Ahmed, Mohamed, Esraa Mohamed Osman, Ibrahim, Gehad Abdelmonem Abdalla, Elsayed, Malaz Ahmed Osman
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 2020 Springer
Subjects:	meta-analysis Review Article sickle cell disease Vitamin D Vitamin D meta-analysis sickle cell disease
Online Access:	Get full text
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Summary:	Vitamin D Deficiency (VDD) is reported to be more frequent with serious clinical outcomes in patients with Sickle Cell Disease (SCD). There is a wide disparity in data in the existing literature regarding the prevalence and risk of VDD in patients with SCD. These data require further summary and analyses for better accuracy. This review aimed to assess the association between VDD and SCD, and was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Medline/ PubMed, World Health Organization Virtual Health Library Science Direct, and Google Scholar were used for the systematic search. A random effects model was used to estimate the pooled prevalence, Risk Ratio (RR), and Standardized Mean Difference (SMD) estimates with the corresponding 95% Confidence Interval (CI) using Open Meta Analyst software version 10.10 (Tufts Medical Center, Boston, MA, USA). Twenty-five studies fulfilled the eligibility criteria. The prevalence of VDD among patients with SCD was 63.8% (95% CI, 52.5–75.1). The risk of VDD among patients with SCD was more than two times that of the general population (RR = 2.129; 95% CI, 1.024–4.423; p < 0.001). Serum vitamin D levels were significantly lower in SCD patients than in their controls (SMD = −1.883: 95% CI, −3.006 to −0.760; p < 0.001). This review provides a comprehensive view of the association between vitamin D status and SCD.
ISSN:	2666-819X 2590-3349 2590-3349
DOI:	10.2991/dsahmj.k.200717.001