The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection

The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection

Background: Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) are linked with functional modification of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses. W...

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Published in:British journal of biomedical science Vol. 75; no. 4; pp. 175 - 181
Main Authors: El-Bendary, M, Neamatallah, M, Elalfy, H, Besheer, T, Elkholi, A, El-Diasty, M, Elsareef, M, Zahran, M, El-Aarag, B, Gomaa, A, Elhammady, D, El-Setouhy, M, Hegazy, A, Esmat, G
Format: Journal Article
Language:English
Published: England Taylor & Francis 02-10-2018
Taylor & Francis Ltd
Subjects:
Alleles
Chronic infection
Females
genetic polymorphism
HCV
Hepatitis C
Immune clearance
Immune response
Infections
Interferon
Males
sex-linked TLR
Single-nucleotide polymorphism
spontaneous clearance
TLR3 protein
TLR7 protein
Toll-like receptors
spontaneous clearance
HCV
sex-linked TLR
genetic polymorphism
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Summary:Background: Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) are linked with functional modification of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses. We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection. Materials & methods: A total of 3368 subjects from 850 families were recruited and divided into three main groups categorized as chronic HCV CHC spontaneous viral clearance (SVC), and controls. All individuals were genotyped for three SNPs for TLR3, two SNPs for TLR7, and two SNPs for TLR8 using allelic discrimination real-time PCR. Results: Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001). Conclusion: The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
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ISSN:0967-4845
2474-0896
DOI:10.1080/09674845.2018.1492186